LLPS-Art-0295
NDX
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Nodulin homeobox; NDX1 homeobox protein homolog; AtNDX1 |
| Gene Name: | NDX, At4g03090, F4C21.1, T4I9.3 |
| Ensembl Gene: | AT4G03090 |
| Ensembl Protein: | AT4G03090.3 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins." | Arabidopsis thaliana cells | 26980300 |
▼ FUNCTION
| Regulates COOLAIR, a set of antisense transcripts originating from the 3' end of FLOWERING LOCUS C (FLC). Associates with single-stranded DNA that is part of an RNA-DNA hybrid, or R-loop, that covers the COOLAIR promoter. R-loop stabilization mediated by NDX inhibits COOLAIR transcription, which in turn modifies FLC expression. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT4G03090.3 | AT4G03090.3 |
| Ensembl | AT4G03090.2 | AT4G03090.2 |
| Ensembl | AT4G03090.1 | AT4G03090.1 |
| Ensembl | AT4G03090.5 | AT4G03090.5 |
| Ensembl | AT4G03090.4 | AT4G03090.4 |
| UniProt | F4JI44, NDX_ARATH, F4JI45, Q7GAL2, Q9ZTA5 | |
| GeneBank | AL161496, CP002687, AF069442, AC005275 | CAB77794.1, AEE82269.1, AAD14437.1, AAC79096.1 |
| RefSeq | NM_116543.6 | NP_192218.5 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVRLLQPKHM VQAVNALHWR NSVEFHKLLK DNGDFSICFN SEQVLPQKIS VEKMVKMLPR 60 61 HLIAVVMTPN KDGKSRYILC GIRLLQTLCD LTPRNAKLEQ VLLDDVKLSA QMIDLVILVI 120 121 IALGRNRKES CNSNKESLLE ATLVASCLHL FHGFISPNSQ DLVLVLLAHP RVDVFIDSAF 180 181 GAVLNVVISL KAKLLYRQTD SPKKLGASSV EEVNFHCQQA EAALQFLHSL CQHKPFRERV 240 241 AKNKELCGKG GVLRLAQSIL SLTITPEFVG ATVTIASTSR MKAKVLSILQ HLFEAESVSF 300 301 LDEVANAGNL HLAKTVASEV LKLLRLGLSK ASMATASPDY PMGFVLLNAM RLADVLTDDS 360 361 NFRSFFTEHF SMVLSAVFCL SHGDFLSMLC SSDLSSREDD ANVDYDLFKS AGWILSVFSS 420 421 SGQSVTPQFK LSLQNNLTMS SYAHQRTSLF IKMIANLHCF VPNVCQEQDR NRFIQNVMSG 480 481 LRKDPSSILI KMLPGSSYTP VAQRGTGVCR NLGSLLRHAE SLIPSSLNEE DFLLLRVFCD 540 541 QLQPLIHSEF EESQVQVKVK KLFALLYIGF TILWLICLVT LIQDIEGRGG NLSGKLKELL 600 601 NLNNEEASED CDVRVEGVMT KQGVNEEIDT VERLKESDAD ASNLETSGSD TSSNRGKGLV 660 661 EEGELVQNMS KRFKGSASGE VKEDEKSETF LVFEKQKKKR KRSIMNADQM GMIEKALAEE 720 721 PDLQRNSASR QLWADKISQK GSEVITSSQL KNWLNNRKAK LARANKQTGP AHDNNSSGDL 780 781 PESPGDENTW QQKPSTPIKD QTVTETPKTG ENLMRTSSSS EEGIKQGQQV RLMDERGDEI 840 841 GKGTVLRTDG EWNGLSLETR QICVVDVMEL SESYDGSKKM IPYGSDDVGR TFTEANSRFG 900 901 VMRVAWDVNK LQY 913 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTTCGAT TGTTGCAGCC TAAACACATG GTACAAGCTG TGAACGCTTT GCATTGGCGA 60 61 AACTCTGTGG AATTTCATAA GCTGCTTAAA GATAATGGAG ATTTCTCTAT TTGCTTTAAC 120 121 TCTGAGCAAG TGTTACCACA AAAGATTAGT GTTGAGAAGA TGGTGAAAAT GTTACCTCGG 180 181 CACCTCATTG CGGTGGTTAT GACTCCTAAT AAAGATGGAA AGTCTCGTTA TATACTGTGT 240 241 GGGATCAGAC TGTTGCAGAC GTTGTGTGAC TTAACACCTC GTAATGCTAA ACTCGAGCAG 300 301 GTCTTGCTTG ACGATGTGAA ATTATCAGCA CAGATGATTG ATCTGGTGAT CCTTGTGATA 360 361 ATAGCTCTTG GCCGTAACAG AAAGGAAAGC TGTAATTCGA ATAAAGAATC GTTACTAGAG 420 421 GCTACATTGG TGGCTTCTTG TCTCCACCTG TTTCACGGGT TTATCTCTCC TAACTCCCAA 480 481 GATCTTGTTC TCGTCTTGCT TGCACACCCA AGGGTTGATG TGTTTATAGA CAGTGCTTTT 540 541 GGAGCTGTTC TCAATGTTGT GATATCTTTG AAAGCGAAGT TGCTGTATAG ACAAACTGAC 600 601 TCCCCAAAAA AGTTAGGCGC AAGTTCTGTA GAGGAGGTTA ACTTCCACTG CCAACAAGCT 660 661 GAAGCTGCTT TGCAGTTCCT TCATTCTCTA TGCCAACACA AACCCTTTAG AGAACGTGTC 720 721 GCTAAAAACA AGGAGCTATG TGGAAAAGGT GGCGTTCTTA GGCTAGCTCA ATCCATACTA 780 781 TCACTAACTA TTACACCTGA ATTTGTTGGA GCAACCGTAA CTATAGCTTC CACATCTAGA 840 841 ATGAAAGCAA AAGTTCTTTC AATTTTGCAG CATCTGTTTG AAGCGGAAAG TGTCTCATTC 900 901 CTTGACGAGG TTGCAAATGC AGGAAACTTG CATTTAGCCA AAACTGTTGC CTCAGAGGTT 960 961 CTTAAATTAT TGAGGCTTGG CCTTTCTAAA GCTTCCATGG CTACTGCTTC TCCTGACTAC 1020 1021 CCGATGGGTT TTGTGCTACT TAACGCTATG CGCTTGGCTG ACGTGCTCAC TGATGACTCA 1080 1081 AATTTTCGAT CTTTTTTCAC TGAACATTTT AGCATGGTTC TCAGCGCGGT ATTTTGTCTC 1140 1141 TCTCATGGAG ATTTCTTGTC AATGTTGTGC TCTTCTGATC TTTCTTCAAG GGAGGATGAT 1200 1201 GCGAATGTTG ATTATGATCT GTTTAAGTCA GCTGGATGGA TTCTAAGTGT ATTTTCATCT 1260 1261 TCTGGGCAAT CAGTCACACC TCAATTCAAG CTCAGTTTAC AAAATAACCT TACCATGTCT 1320 1321 TCATATGCAC ATCAACGAAC ATCCTTATTT ATTAAAATGA TTGCGAATCT TCACTGTTTC 1380 1381 GTTCCCAACG TGTGCCAAGA ACAGGATAGG AACCGTTTCA TTCAGAATGT TATGAGTGGA 1440 1441 TTGCGAAAAG ATCCTTCAAG CATATTGATT AAGATGTTAC CAGGCTCTTC ATATACTCCT 1500 1501 GTGGCACAGA GAGGCACTGG TGTTTGCAGA AACCTAGGTT CTCTGTTGCG CCATGCAGAA 1560 1561 TCCTTGATCC CTAGTTCCCT CAACGAGGAA GATTTTCTGC TTTTGAGGGT GTTTTGTGAC 1620 1621 CAGTTACAGC CGTTAATCCA TTCCGAGTTT GAGGAAAGTC AAGTACAGGT GAAGGATATT 1680 1681 GAAGGTAGGG GCGGGAATTT ATCTGGTAAG CTAAAAGAGC TTCTGAATCT TAACAATGAG 1740 1741 GAAGCTTCAG AGGATTGTGA TGTCCGAGTT GAAGGTGTGA TGACAAAGCA AGGCGTGAAC 1800 1801 GAGGAGATAG ACACAGTTGA AAGGTTGAAA GAGAGCGATG CAGATGCTAG CAATCTTGAA 1860 1861 ACCAGTGGTT CAGATACAAG CTCTAACAGA GGGAAGGGTC TGGTTGAAGA GGGAGAGTTG 1920 1921 GTTCAGAATA TGAGCAAGCG ATTTAAAGGC AGTGCATCAG GAGAGGTGAA GGAGGATGAG 1980 1981 AAATCTGAAA CCTTCCTTGT CTTTGAGAAG CAGAAGAAGA AACGGAAGCG TAGTATTATG 2040 2041 AATGCTGATC AAATGGGGAT GATTGAGAAG GCGCTTGCTG AAGAACCTGA TTTGCAGCGG 2100 2101 AATTCAGCTT CGAGACAGTT ATGGGCTGAT AAAATAAGTC AAAAGGTGAG TTCAAGAATT 2160 2161 CTACTCTTTT TAATTTCCAA CCACGTATTA CGAACGATGC GCTCGTTGAT TACATGA 2217 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Molecular Function | Single-stranded DNA binding | |
Biological Process | Flower development | |
Biological Process | Negative regulation of antisense RNA transcription |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Arl-0038 | Arabidopsis lyrata | 90.49 | 0.0 | 1636 |
| LLPS-Brn-1202 | Brassica napus | 67.85 | 0.0 | 1205 |
| LLPS-Brr-0973 | Brassica rapa | 67.71 | 0.0 | 1194 |
| LLPS-Bro-2525 | Brassica oleracea | 67.71 | 0.0 | 1205 |
| LLPS-Gor-2016 | Gossypium raimondii | 53.15 | 3e-172 | 532 |
| LLPS-Pot-2430 | Populus trichocarpa | 52.83 | 0.0 | 557 |
| LLPS-Coc-1031 | Corchorus capsularis | 51.58 | 2e-157 | 503 |
| LLPS-Prp-1922 | Prunus persica | 50.09 | 3e-164 | 512 |
| LLPS-Phv-1866 | Phaseolus vulgaris | 49.82 | 9e-155 | 486 |
| LLPS-Vir-1530 | Vigna radiata | 48.64 | 8e-94 | 308 |
| LLPS-Glm-2203 | Glycine max | 48.55 | 3e-152 | 480 |
| LLPS-Met-2259 | Medicago truncatula | 47.85 | 3e-147 | 468 |
| LLPS-Thc-2139 | Theobroma cacao | 47.49 | 0.0 | 717 |
| LLPS-Mae-2059 | Manihot esculenta | 47.26 | 0.0 | 754 |
| LLPS-Sol-2212 | Solanum lycopersicum | 45.14 | 1e-132 | 428 |
| LLPS-Viv-2275 | Vitis vinifera | 44.97 | 0.0 | 696 |
| LLPS-Hea-0009 | Helianthus annuus | 41.74 | 4e-27 | 122 |
| LLPS-Ori-2272 | Oryza indica | 41.71 | 5e-74 | 266 |
| LLPS-Zem-1556 | Zea mays | 41.58 | 6e-105 | 353 |
| LLPS-Via-1510 | Vigna angularis | 41.35 | 0.0 | 590 |
| LLPS-Brd-2206 | Brachypodium distachyon | 41.28 | 2e-101 | 343 |
| LLPS-Cus-0153 | Cucumis sativus | 41.15 | 0.0 | 647 |
| LLPS-Nia-1895 | Nicotiana attenuata | 41.06 | 0.0 | 577 |
| LLPS-Sob-0889 | Sorghum bicolor | 41.01 | 1e-104 | 355 |
| LLPS-Sei-1944 | Setaria italica | 40.88 | 2e-105 | 355 |
| LLPS-Orbr-1784 | Oryza brachyantha | 40.7 | 2e-97 | 333 |
| LLPS-Hov-0911 | Hordeum vulgare | 40.65 | 5e-103 | 348 |
| LLPS-Org-1847 | Oryza glaberrima | 40.43 | 7e-98 | 335 |
| LLPS-Tru-0734 | Triticum urartu | 40.24 | 4e-36 | 151 |
| LLPS-Amt-0552 | Amborella trichopoda | 40.14 | 5e-114 | 381 |
| LLPS-Lep-1481 | Leersia perrieri | 38.67 | 1e-87 | 305 |
| LLPS-Orp-2038 | Oryza punctata | 38.35 | 5e-84 | 295 |
| LLPS-Ors-2299 | Oryza sativa | 38.34 | 1e-22 | 107 |
| LLPS-Orb-0064 | Oryza barthii | 38.27 | 4e-59 | 221 |
| LLPS-Dac-0024 | Daucus carota | 38.17 | 5e-165 | 513 |
| LLPS-Orr-1248 | Oryza rufipogon | 38.15 | 2e-84 | 296 |
| LLPS-Orgl-0542 | Oryza glumaepatula | 38.04 | 1e-82 | 291 |
| LLPS-Orni-1545 | Oryza nivara | 37.86 | 3e-82 | 290 |
| LLPS-Tra-0878 | Triticum aestivum | 35.93 | 1e-150 | 475 |
| LLPS-Orm-1848 | Oryza meridionalis | 35.89 | 1e-49 | 192 |
| LLPS-Mua-1243 | Musa acuminata | 35.01 | 6e-123 | 399 |
| LLPS-Sem-1110 | Selaginella moellendorffii | 34.8 | 2e-22 | 107 |
| LLPS-Php-1533 | Physcomitrella patens | 31.82 | 2e-23 | 110 |