• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aon-1861
PABPC4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Polyadenylate-binding protein
Gene Name: PABPC4
Ensembl Gene: ENSANAG00000025079.1
Ensembl Protein: ENSANAP00000014504.1
Organism: Aotus nancymaae
Taxa ID: 37293
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-body, Stress granule, Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION

Binds the poly(A) tail of mRNA.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNAAASSYPM  ASLYVGDLHS  DVTEAMLYEK  FSPAGPVLSI  RVCRDMITRR  SLGYAYVNFQ  60
61    QPADAERALD  TMNFDVIKGK  PIRIMWSQRD  PSLRKSGVGN  VFIKNLDKSI  DNKALYDTFS  120
121   AFGNILSCKV  VCDENGSKGY  AFVHFETQEA  ADKAIEKMNG  MLLNDRKVFV  GRFKSRKERE  180
181   AELGAKAKEF  TNVYIKNFGE  EVDDENLKEL  FSQFGKTLSV  KVMRDPNGKS  KGFGFVSYEK  240
241   HEDANKAVEE  MNGKEISGKI  IFVGRAQKKV  ERQAELKRKF  EQLKQERISR  YQGVNLYIKN  300
301   LDDTIDDEKL  RKEFSPFGSI  TSAKVMLEDG  RSKGFGFVCF  SSPEEATKAV  TEMNGRIVGS  360
361   KPLYVALAQR  KEERKAHLTN  QYMQRVAGMR  ALPANAILNQ  FQPAAGGYFV  PAVPQAQGRP  420
421   PYYTPNQLAQ  MRPNPRWQQG  GRPQGFQGMP  SAIRQSGPRP  TLRHLAPTGN  APASRGLPTT  480
481   TQRVGSECPD  RLAMDFGGAG  AAQQGLTDSC  QSGGVPTAVQ  NLAPRAAVAA  AAPRAVAPYK  540
541   YASSVRSPHP  AIQPLQAPQP  AVHVQGQEPL  TASMLAAAPP  QEQKQMLGER  LFPLIQTMHS  600
601   NLAGKITGML  LEIDNSELLH  MLESPESLRS  KVDEAVAVLQ  AHHAKKEAAQ  KVGAVAAATS  660
Nucleotide CDS Sequence (FASTA)
1     ATGAACGCTG  CGGCCAGCAG  CTACCCCATG  GCCTCCCTGT  ACGTGGGCGA  CCTGCACTCG  60
61    GACGTCACCG  AGGCCATGCT  GTACGAAAAG  TTCAGCCCCG  CGGGGCCTGT  GCTGTCCATC  120
121   CGGGTCTGCC  GCGACATGAT  CACCCGCCGC  TCCTTGGGCT  ATGCCTACGT  CAACTTCCAG  180
181   CAGCCGGCCG  ATGCTGAGCG  GGCTTTGGAC  ACCATGAACT  TTGATGTGAT  TAAGGGAAAG  240
241   CCAATCCGCA  TCATGTGGTC  TCAGAGGGAT  CCCTCTTTGA  GAAAATCTGG  TGTGGGAAAC  300
301   GTCTTCATCA  AGAACCTGGA  CAAATCTATA  GATAACAAGG  CACTTTATGA  TACTTTTTCT  360
361   GCTTTTGGAA  ACATTCTATC  CTGCAAGGTG  GTGTGCGATG  AGAACGGCTC  GAAGGGTTAT  420
421   GCCTTTGTCC  ACTTCGAGAC  CCAAGAGGCT  GCCGACAAGG  CCATCGAGAA  GATGAATGGC  480
481   ATGCTCCTCA  ATGACCGCAA  AGTATTTGTG  GGCAGATTCA  AGTCTCGCAA  AGAGCGGGAA  540
541   GCCGAGCTTG  GAGCCAAAGC  CAAGGAATTC  ACCAATGTTT  ATATCAAAAA  CTTCGGGGAA  600
601   GAGGTGGATG  ATGAGAATCT  GAAAGAGCTA  TTCAGTCAGT  TTGGTAAGAC  CCTGAGTGTC  660
661   AAGGTGATGA  GAGATCCCAA  TGGGAAATCC  AAAGGCTTTG  GCTTTGTGAG  TTACGAAAAA  720
721   CACGAGGATG  CCAATAAGGC  TGTGGAAGAG  ATGAATGGAA  AAGAAATAAG  TGGGAAAATC  780
781   ATATTTGTAG  GCCGTGCACA  AAAGAAAGTA  GAACGGCAGG  CAGAGTTAAA  ACGGAAATTT  840
841   GAGCAGTTGA  AACAGGAGAG  AATTAGTCGA  TATCAGGGGG  TGAATCTCTA  CATTAAGAAC  900
901   TTGGATGATA  CTATTGATGA  TGAGAAATTA  AGGAAAGAGT  TTTCTCCTTT  TGGATCAATT  960
961   ACCAGTGCTA  AGGTAATGTT  GGAAGATGGA  AGAAGCAAAG  GGTTTGGCTT  CGTCTGCTTC  1020
1021  TCATCTCCTG  AAGAGGCAAC  CAAAGCAGTC  ACTGAGATGA  ATGGACGCAT  TGTGGGTTCC  1080
1081  AAGCCACTAT  ATGTTGCCCT  GGCCCAGAGG  AAGGAAGAGA  GAAAGGCTCA  CCTGACCAAC  1140
1141  CAGTATATGC  AACGAGTGGC  TGGAATGAGA  GCACTTCCTG  CCAATGCCAT  CTTAAATCAG  1200
1201  TTCCAGCCTG  CAGCGGGTGG  CTACTTTGTG  CCAGCAGTCC  CACAGGCTCA  GGGAAGGCCT  1260
1261  CCATATTATA  CACCTAACCA  GTTAGCACAG  ATGAGGCCTA  ATCCACGCTG  GCAGCAAGGT  1320
1321  GGGAGACCTC  AAGGCTTCCA  AGGAATGCCG  AGTGCTATAC  GCCAGTCTGG  GCCTCGTCCA  1380
1381  ACTCTTCGCC  ATCTGGCTCC  AACTGGTAAT  GCTCCGGCCT  CTCGTGGCCT  CCCTACTACC  1440
1441  ACTCAGAGAG  TCGGGTCTGA  GTGCCCGGAC  CGCTTGGCTA  TGGACTTTGG  TGGGGCTGGT  1500
1501  GCCGCCCAGC  AAGGGCTGAC  TGACAGCTGC  CAGTCTGGAG  GCGTTCCCAC  AGCTGTGCAG  1560
1561  AACTTAGCGC  CACGCGCTGC  TGTTGCTGCT  GCTGCTCCCC  GGGCTGTTGC  CCCCTACAAA  1620
1621  TACGCCTCCA  GTGTCCGCAG  CCCTCATCCT  GCCATACAGC  CTCTGCAGGC  ACCGCAACCT  1680
1681  GCGGTCCATG  TGCAGGGGCA  GGAGCCACTG  ACTGCCTCCA  TGCTGGCCGC  AGCACCCCCC  1740
1741  CAGGAACAGA  AGCAGATGCT  GGGAGAACGC  TTATTCCCAC  TCATCCAAAC  AATGCATTCA  1800
1801  AACCTGGCTG  GAAAAATCAC  GGGAATGCTG  CTGGAGATCG  ACAACTCTGA  GCTACTGCAC  1860
1861  ATGTTAGAGT  CCCCTGAGTC  TCTCCGCTCC  AAGGTGGATG  AAGCTGTAGC  AGTTCTACAG  1920
1921  GCTCATCATG  CCAAGAAAGA  AGCTGCCCAG  AAGGTGGGCG  CTGTTGCTGC  TGCTACCTCT  1980
1981  TAG  1983

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Reference proteome
Repeat
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasmic stress granule
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
MRNA binding
Molecular Function
Poly(A) binding
Molecular Function
Poly(U) RNA binding
Biological Process
Myeloid cell development
Biological Process
Regulation of mRNA stability

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Poa-3141Pongo abelii99.840.01252
LLPS-Pat-0778Pan troglodytes99.840.01252
LLPS-Pap-2020Pan paniscus99.840.01252
LLPS-Hos-1900Homo sapiens99.840.01252
LLPS-Gog-0305Gorilla gorilla99.840.01252
LLPS-Mam-2804Macaca mulatta99.690.01251
LLPS-Rhb-2483Rhinopithecus bieti99.690.01251
LLPS-Mal-2087Mandrillus leucophaeus99.690.01251
LLPS-Cea-4399Cercocebus atys99.690.01251
LLPS-Maf-0352Macaca fascicularis99.690.01251
LLPS-Chs-3703Chlorocebus sabaeus99.690.01251
LLPS-Cap-1285Cavia porcellus99.530.01248
LLPS-Man-3264Macaca nemestrina99.530.01251
LLPS-Paa-3212Papio anubis99.530.01248
LLPS-Caj-1974Callithrix jacchus99.530.01249
LLPS-Cas-0281Carlito syrichta99.220.01253
LLPS-Fud-1586Fukomys damarensis99.220.01247
LLPS-Sus-0113Sus scrofa99.220.01247
LLPS-Fec-4755Felis catus99.060.01244
LLPS-Mup-1068Mustela putorius furo99.060.01244
LLPS-Ova-0412Ovis aries99.060.01245
LLPS-Orc-2217Oryctolagus cuniculus99.050.01228
LLPS-Loa-2227Loxodonta africana98.90.01245
LLPS-Caf-3707Canis familiaris98.780.01110
LLPS-Urm-0246Ursus maritimus98.750.01240
LLPS-Aim-2582Ailuropoda melanoleuca98.750.01239
LLPS-Mum-4380Mus musculus98.120.01231
LLPS-Nol-0453Nomascus leucogenys97.180.01209
LLPS-Dio-0764Dipodomys ordii97.030.01204
LLPS-Ict-0153Ictidomys tridecemlineatus96.710.01204
LLPS-Ere-0400Erinaceus europaeus96.090.01196
LLPS-Bot-3027Bos taurus95.780.01202
LLPS-Ran-1183Rattus norvegicus95.770.01191
LLPS-Otg-1196Otolemur garnettii95.640.01198
LLPS-Eqc-3683Equus caballus92.430.01224
LLPS-Myl-0240Myotis lucifugus92.180.01131
LLPS-Mod-0515Monodelphis domestica89.060.01113
LLPS-Sah-0778Sarcophilus harrisii88.260.01112
LLPS-Gaga-0977Gallus gallus87.950.01103
LLPS-Pes-0072Pelodiscus sinensis87.950.01105
LLPS-Tag-0673Taeniopygia guttata87.830.01106
LLPS-Ora-1046Ornithorhynchus anatinus87.480.01092
LLPS-Meg-0778Meleagris gallopavo87.330.0 979
LLPS-Fia-0491Ficedula albicollis87.170.01092
LLPS-Anc-1818Anolis carolinensis85.920.0 944
LLPS-Lac-0500Latimeria chalumnae83.670.01063
LLPS-Scf-1457Scleropages formosus81.640.0 992
LLPS-Leo-0829Lepisosteus oculatus80.720.01019
LLPS-Dar-0368Danio rerio80.00.01013
LLPS-Icp-2412Ictalurus punctatus80.00.01006
LLPS-Xet-2658Xenopus tropicalis79.970.01004
LLPS-Orn-2604Oreochromis niloticus79.190.01000
LLPS-Scm-2077Scophthalmus maximus79.190.0 985
LLPS-Xim-0027Xiphophorus maculatus78.880.0 996
LLPS-Tar-2527Takifugu rubripes78.760.0 987
LLPS-Pof-3249Poecilia formosa78.570.0 998
LLPS-Orl-1089Oryzias latipes78.110.0 987
LLPS-Ten-0131Tetraodon nigroviridis75.70.0 928
LLPS-Gaa-0140Gasterosteus aculeatus73.580.0 943
LLPS-Asm-0750Astyanax mexicanus73.330.0 942
LLPS-Tut-0106Tursiops truncatus73.320.0 931
LLPS-Anp-0205Anas platyrhynchos72.560.0 822
LLPS-Mea-0928Mesocricetus auratus70.020.0 879
LLPS-Drm-0098Drosophila melanogaster67.630.0 605
LLPS-Crn-0202Cryptococcus neoformans64.293e-1789.7
LLPS-Cae-0017Caenorhabditis elegans62.58e-21 101
LLPS-Php-0547Physcomitrella patens61.563e-161 486
LLPS-Cis-0525Ciona savignyi61.220.0 741
LLPS-Abg-0396Absidia glauca60.661e-1378.6
LLPS-Mel-0295Melampsora laricipopulina58.94e-1583.2
LLPS-Scj-1152Schizosaccharomyces japonicus58.62e-162 489
LLPS-Pug-0751Puccinia graminis57.141e-1379.0
LLPS-Sem-1150Selaginella moellendorffii50.01e-179 533
LLPS-Scp-0021Schizosaccharomyces pombe48.660.0 545
LLPS-Orp-0276Oryza punctata47.039e-171 510
LLPS-Orm-0242Oryza meridionalis46.851e-169 508
LLPS-Org-0518Oryza glaberrima46.71e-169 508
LLPS-Orgl-1206Oryza glumaepatula46.72e-169 507
LLPS-Orb-0262Oryza barthii46.71e-169 508
LLPS-Orr-0393Oryza rufipogon46.543e-169 506
LLPS-Ors-1964Oryza sativa46.543e-169 506
LLPS-Orni-0813Oryza nivara46.543e-169 506
LLPS-Sei-0885Setaria italica46.522e-172 515
LLPS-Orbr-0897Oryza brachyantha46.256e-162 488
LLPS-Zem-1330Zea mays45.91e-167 502
LLPS-Fuv-0450Fusarium verticillioides45.456e-171 514
LLPS-Fuo-0124Fusarium oxysporum45.313e-171 514
LLPS-Arl-2426Arabidopsis lyrata45.238e-169 506
LLPS-Prp-0523Prunus persica44.386e-167 500
LLPS-Art-2631Arabidopsis thaliana44.22e-162 490
LLPS-Brr-0967Brassica rapa44.039e-164 493