• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Anp-0271
PPME1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein phosphatase methylesterase 1
Gene Name: PPME1
Ensembl Gene: ENSAPLG00000006631.1
Ensembl Protein: ENSAPLP00000006286.1
Organism: Anas platyrhynchos
Taxa ID: 8839
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Demethylates proteins that have been reversibly carboxymethylated.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSAPLT00000006929.1ENSAPLP00000006286.1
UniProtU3IGB4, U3IGB4_ANAPL
GeneBankADON01124938, ADON01124939

▼ SEQUENCE

Protein Sequence (FASTA)
1     SPGRKRDFSP  VLWSQYFESM  EDVVVENETG  KDTFRIYKSG  SEGPVLLLLH  GGGHSALSWA  60
61    VFTSAIISRI  QCRIVALDLR  GHGETKVRNP  EDLSAETMSK  DVGNVVEALY  GDLPPPIMLI  120
121   GHSMGGAIAV  HTAVANLVPS  LLGLCMIDVV  EGTAMDALNS  MQNFLRSRPK  TFKSLENAIE  180
181   WSVKSGQIRN  LESARVSMVG  QVKQCEGAAS  PECPKAIVEG  IIEEEEEEEE  DDEGGGSVNK  240
241   RKKEDDTETK  KEHLYTWRIE  LAKTEKYWDG  WFRGLSNLFL  SCPTPKLLLL  AGVDRLDKDL  300
301   TIGQMQGKFQ  MQVLPQCGHA  VHEDAPDKVA  EAVATFLIRH  RFTEPIGGFQ  350
Nucleotide CDS Sequence (FASTA)
1     AGCCCTGGAA  GAAAGCGTGA  TTTCTCCCCG  GTGCTTTGGA  GCCAGTACTT  TGAGTCTATG  60
61    GAGGACGTTG  TGGTAGAAAA  CGAAACCGGC  AAGGACACTT  TTCGAATTTA  CAAAAGTGGC  120
121   TCGGAGGGAC  CTGTCTTACT  GCTCCTACAC  GGTGGAGGCC  ATTCTGCTCT  TTCCTGGGCT  180
181   GTGTTTACTT  CTGCAATCAT  TAGCAGGATT  CAGTGTAGGA  TTGTGGCTTT  AGATCTCCGG  240
241   GGCCATGGAG  AAACAAAAGT  TAGGAATCCT  GAAGACCTGT  CTGCAGAGAC  GATGTCCAAA  300
301   GATGTTGGAA  ACGTGGTTGA  AGCCCTGTAC  GGGGACCTCC  CTCCCCCCAT  CATGCTCATT  360
361   GGGCACAGCA  TGGGGGGTGC  CATTGCGGTG  CACACGGCGG  TCGCCAACTT  GGTGCCGAGC  420
421   TTACTGGGGC  TGTGCATGAT  AGACGTTGTG  GAAGGTACGG  CCATGGATGC  ATTGAACAGC  480
481   ATGCAGAACT  TCTTACGGAG  TCGTCCCAAA  ACGTTCAAGT  CGCTTGAGAA  TGCAATCGAG  540
541   TGGAGTGTTA  AAAGTGGACA  AATAAGAAAT  CTTGAATCTG  CTAGAGTTTC  TATGGTCGGT  600
601   CAAGTCAAAC  AGTGCGAGGG  AGCTGCTAGT  CCTGAATGTC  CTAAAGCCAT  AGTGGAGGGC  660
661   ATTATTGAAG  AGGAGGAGGA  GGAGGAAGAG  GATGATGAAG  GGGGTGGCTC  TGTCAACAAA  720
721   AGGAAGAAGG  AAGATGACAC  AGAGACAAAG  AAGGAGCACT  TATACACGTG  GCGAATTGAA  780
781   CTGGCGAAAA  CAGAAAAGTA  CTGGGATGGC  TGGTTCAGGG  GGTTATCTAA  CCTCTTCCTA  840
841   AGCTGTCCAA  CTCCAAAGCT  TTTGCTTTTA  GCTGGTGTTG  ACAGGCTGGA  TAAAGATCTA  900
901   ACAATTGGAC  AGATGCAAGG  GAAGTTCCAG  ATGCAAGTCC  TGCCACAGTG  CGGCCACGCA  960
961   GTCCATGAAG  ATGCTCCAGA  CAAGGTTGCT  GAAGCTGTTG  CGACGTTCCT  GATCCGTCAC  1020
1021  AGGTTTACAG  AGCCCATCGG  TGGATTCCAG  1050

▼ KEYWORD

ID
Family
Complete proteome
Hydrolase
Reference proteome
Serine esterase

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Protein C-terminal methylesterase activity
Molecular Function
Protein phosphatase 2A binding
Biological Process
Protein demethylation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-3614Gallus gallus99.140.0 625
LLPS-Meg-1344Meleagris gallopavo98.860.0 622
LLPS-Fia-2611Ficedula albicollis96.870.0 619
LLPS-Tag-2743Taeniopygia guttata95.130.0 602
LLPS-Pes-2942Pelodiscus sinensis94.030.0 600
LLPS-Ora-2803Ornithorhynchus anatinus92.860.0 592
LLPS-Bot-4341Bos taurus91.120.0 583
LLPS-Fec-2828Felis catus90.830.0 581
LLPS-Caf-4217Canis familiaris90.830.0 581
LLPS-Eqc-0585Equus caballus90.570.0 521
LLPS-Mum-3703Mus musculus90.540.0 580
LLPS-Dio-4042Dipodomys ordii90.540.0 580
LLPS-Mup-1367Mustela putorius furo90.540.0 579
LLPS-Mod-0188Monodelphis domestica90.40.0 586
LLPS-Mea-3798Mesocricetus auratus90.260.0 577
LLPS-Gog-4263Gorilla gorilla90.260.0 578
LLPS-Fud-3068Fukomys damarensis90.260.0 577
LLPS-Ran-3833Rattus norvegicus90.260.0 579
LLPS-Aim-2094Ailuropoda melanoleuca90.260.0 583
LLPS-Pap-4222Pan paniscus90.260.0 578
LLPS-Rhb-0194Rhinopithecus bieti90.260.0 578
LLPS-Poa-3701Pongo abelii90.260.0 578
LLPS-Cap-0906Cavia porcellus89.970.0 577
LLPS-Ict-3903Ictidomys tridecemlineatus89.970.0 577
LLPS-Chs-3198Chlorocebus sabaeus89.940.0 517
LLPS-Ova-4137Ovis aries89.830.0 571
LLPS-Caj-3747Callithrix jacchus89.670.0 536
LLPS-Sah-1650Sarcophilus harrisii89.430.0 579
LLPS-Aon-3972Aotus nancymaae89.291e-77 248
LLPS-Otg-0269Otolemur garnettii89.20.0 569
LLPS-Mam-3992Macaca mulatta88.380.0 514
LLPS-Orc-0997Oryctolagus cuniculus88.250.0 587
LLPS-Lac-3594Latimeria chalumnae87.561e-127 375
LLPS-Myl-0410Myotis lucifugus87.50.0 570
LLPS-Loa-3544Loxodonta africana87.460.0 573
LLPS-Paa-3262Papio anubis86.390.0 571
LLPS-Mal-1418Mandrillus leucophaeus86.390.0 572
LLPS-Pat-0680Pan troglodytes86.390.0 571
LLPS-Hos-1939Homo sapiens86.390.0 571
LLPS-Anc-1803Anolis carolinensis85.385e-109 324
LLPS-Xet-3894Xenopus tropicalis85.190.0 564
LLPS-Maf-4716Macaca fascicularis84.12e-165 474
LLPS-Cea-4172Cercocebus atys84.12e-165 475
LLPS-Man-4064Macaca nemestrina84.12e-165 474
LLPS-Cas-2062Carlito syrichta83.890.0 564
LLPS-Leo-0855Lepisosteus oculatus82.570.0 531
LLPS-Sus-3443Sus scrofa81.143e-166 476
LLPS-Asm-3274Astyanax mexicanus79.942e-177 505
LLPS-Urm-4014Ursus maritimus79.779e-165 472
LLPS-Nol-3526Nomascus leucogenys79.490.0 516
LLPS-Scf-2262Scleropages formosus79.430.0 521
LLPS-Dar-2405Danio rerio79.146e-178 506
LLPS-Xim-2679Xiphophorus maculatus79.082e-180 513
LLPS-Icp-2976Ictalurus punctatus78.493e-179 509
LLPS-Pof-3479Poecilia formosa77.884e-162 464
LLPS-Scm-3675Scophthalmus maximus77.593e-179 509
LLPS-Orn-0807Oreochromis niloticus77.31e-177 505
LLPS-Orl-1161Oryzias latipes76.725e-177 504
LLPS-Tar-1490Takifugu rubripes76.720.0 513
LLPS-Ten-2231Tetraodon nigroviridis76.442e-175 500
LLPS-Gaa-1819Gasterosteus aculeatus76.151e-176 503
LLPS-Phn-0323Phaeosphaeria nodorum59.32e-27 114
LLPS-Aso-1046Aspergillus oryzae54.658e-25 104
LLPS-Asf-0440Aspergillus flavus54.652e-23 104
LLPS-Orb-0671Oryza barthii51.722e-2197.4
LLPS-Orni-2096Oryza nivara51.729e-2298.2
LLPS-Orgl-2359Oryza glumaepatula51.721e-2197.8
LLPS-Orp-2204Oryza punctata51.721e-2197.4
LLPS-Orr-1434Oryza rufipogon51.721e-2197.8
LLPS-Cii-2243Ciona intestinalis51.474e-60 199
LLPS-Cis-0855Ciona savignyi49.711e-104 318
LLPS-Sac-1047Saccharomyces cerevisiae47.34e-1579.7
LLPS-Hea-1642Helianthus annuus46.871e-90 283
LLPS-Viv-0868Vitis vinifera46.291e-91 285
LLPS-Met-2365Medicago truncatula46.276e-90 280
LLPS-Coc-0635Corchorus capsularis46.279e-90 281
LLPS-Pot-0977Populus trichocarpa45.997e-93 288
LLPS-Mae-0379Manihot esculenta45.997e-90 280
LLPS-Gor-1524Gossypium raimondii45.974e-88 276
LLPS-Phv-2543Phaseolus vulgaris45.977e-90 280
LLPS-Nia-2363Nicotiana attenuata45.722e-76 243
LLPS-Drm-1337Drosophila melanogaster45.65e-96 298
LLPS-Dac-0268Daucus carota45.492e-71 234
LLPS-Prp-0686Prunus persica45.375e-87 273
LLPS-Lep-0171Leersia perrieri45.077e-87 272
LLPS-Tra-2021Triticum aestivum45.073e-87 273
LLPS-Cus-2016Cucumis sativus45.072e-87 274
LLPS-Orbr-2299Oryza brachyantha45.071e-86 271
LLPS-Amt-1178Amborella trichopoda45.072e-85 270
LLPS-Php-2330Physcomitrella patens45.025e-80 257
LLPS-Sob-1084Sorghum bicolor44.782e-86 271
LLPS-Org-0973Oryza glaberrima44.788e-87 272
LLPS-Cae-0450Caenorhabditis elegans44.771e-94 293
LLPS-Ori-1347Oryza indica44.481e-85 268
LLPS-Brd-0155Brachypodium distachyon44.481e-84 268
LLPS-Arl-2040Arabidopsis lyrata44.486e-87 273
LLPS-Ors-1147Oryza sativa44.481e-85 269
LLPS-Sei-1834Setaria italica44.183e-84 265
LLPS-Glm-0367Glycine max44.033e-86 271
LLPS-Art-2780Arabidopsis thaliana44.021e-86 272
LLPS-Sol-1025Solanum lycopersicum43.923e-84 267
LLPS-Mua-1542Musa acuminata43.921e-86 272
LLPS-Brn-2484Brassica napus43.885e-86 270
LLPS-Brr-2302Brassica rapa43.885e-86 270
LLPS-Bro-2497Brassica oleracea43.882e-85 268
LLPS-Thc-2397Theobroma cacao43.417e-86 271
LLPS-Sem-1991Selaginella moellendorffii43.23e-81 258
LLPS-Zem-1972Zea mays43.062e-82 261
LLPS-Miv-0300Microbotryum violaceum42.861e-0959.7
LLPS-Cym-0999Cyanidioschyzon merolae42.539e-69 229
LLPS-Via-1211Vigna angularis41.442e-83 267
LLPS-Vir-1860Vigna radiata40.776e-66 218
LLPS-Orm-0496Oryza meridionalis40.63e-71 231
LLPS-Tru-1761Triticum urartu40.61e-71 233
LLPS-Mao-0856Magnaporthe oryzae39.262e-62 211
LLPS-Usm-1484Ustilago maydis39.069e-56 195
LLPS-Scs-0900Sclerotinia sclerotiorum38.869e-63 212
LLPS-Ved-0469Verticillium dahliae38.77e-60 204
LLPS-Spr-0870Sporisorium reilianum38.263e-52 186
LLPS-Fus-0820Fusarium solani37.753e-58 200
LLPS-Tum-1402Tuber melanosporum37.328e-63 212
LLPS-Yal-0043Yarrowia lipolytica37.292e-55 192
LLPS-Cogr-0359Colletotrichum graminicola37.221e-58 201
LLPS-Asn-0466Aspergillus nidulans36.994e-50 178
LLPS-Pug-1316Puccinia graminis36.846e-1781.6
LLPS-Mel-1306Melampsora laricipopulina36.821e-52 184
LLPS-Scp-1583Schizosaccharomyces pombe36.85e-60 202
LLPS-Gas-0665Galdieria sulphuraria36.81e-65 219
LLPS-Coo-1565Colletotrichum orbiculare36.781e-55 193
LLPS-Beb-1095Beauveria bassiana36.684e-63 213
LLPS-Fuo-1019Fusarium oxysporum36.62e-57 197
LLPS-Crn-0701Cryptococcus neoformans36.51e-45 167
LLPS-Pyt-1195Pyrenophora teres36.493e-53 186
LLPS-Pytr-1341Pyrenophora triticirepentis36.494e-53 186
LLPS-Nec-0458Neurospora crassa36.226e-64 216
LLPS-Asc-0697Aspergillus clavatus36.151e-52 185
LLPS-Nef-1168Neosartorya fischeri36.053e-54 190
LLPS-Fuv-1246Fusarium verticillioides35.927e-56 193
LLPS-Trr-0539Trichoderma reesei35.711e-57 198
LLPS-Chc-0394Chondrus crispus35.674e-49 174
LLPS-Asfu-0902Aspergillus fumigatus35.54e-51 181
LLPS-Abg-1146Absidia glauca35.476e-51 179
LLPS-Trv-1468Trichoderma virens35.434e-56 194
LLPS-Osl-0943Ostreococcus lucimarinus35.414e-54 185
LLPS-Gag-0311Gaeumannomyces graminis35.223e-53 188
LLPS-Lem-0249Leptosphaeria maculans35.211e-52 184
LLPS-Ast-0492Aspergillus terreus35.211e-55 193
LLPS-Scj-0538Schizosaccharomyces japonicus35.141e-55 191
LLPS-Asni-0998Aspergillus niger34.995e-50 178
LLPS-Blg-1235Blumeria graminis34.874e-55 192
LLPS-Chr-1007Chlamydomonas reinhardtii34.552e-55 194
LLPS-Put-1184Puccinia triticina34.393e-52 183
LLPS-Zyt-1371Zymoseptoria tritici33.431e-42 157
LLPS-Dos-1472Dothistroma septosporum32.31e-46 169
LLPS-Scc-1555Schizosaccharomyces cryophilus32.086e-51 179
LLPS-Kop-0797Komagataella pastoris31.533e-41 155
LLPS-Asg-0981Ashbya gossypii30.111e-30 124
LLPS-Cog-1197Colletotrichum gloeosporioides29.313e-28 117