• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Fia-2611
PPME1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein phosphatase methylesterase 1
Gene Name: PPME1
Ensembl Gene: ENSFALG00000004819.1
Ensembl Protein: ENSFALP00000005015.1
Organism: Ficedula albicollis
Taxa ID: 59894
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Demethylates proteins that have been reversibly carboxymethylated.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEFFLFCSPG  RKRDFSPVLW  SQYFESMEDV  VVENDTGKDT  FRIYKSGLEG  PVLLLLHGGG  60
61    HSALSWAVFT  SAIISRIQCR  IVALDLRGHG  ETKVRNPEDL  SAETMSKDVG  SVVEALYGDL  120
121   PPPIMLIGHS  MGGAIAVHTA  VANLVPSLLG  LCMIDVVEGT  AMDALNSMQN  FLRSRPKTFK  180
181   SLENAIEWSV  KSGQIRNLES  ARVSMVGQVK  QCEGPASPEC  PKAIVEGIIE  EEEEEEDEDE  240
241   EGGGSVNKRK  KEDDTEIKKE  HLYTWRIELA  KTEKYWDGWF  RGLSNLFLSC  PTPKLLLLAG  300
301   VDRLDKDLTI  GQMQGKFQMQ  VLPQCGHAVH  EDAPDKVAEA  VATFLIRHRF  TEPIGGFQCV  360
361   FPAC  364
Nucleotide CDS Sequence (FASTA)
1     ATGGAATTTT  TCCTGTTTTG  CAGCCCTGGA  AGAAAGCGTG  ATTTTTCACC  AGTGCTTTGG  60
61    AGCCAGTACT  TTGAGTCCAT  GGAGGATGTT  GTGGTAGAAA  ATGACACTGG  CAAGGATACT  120
121   TTTCGAATTT  ACAAAAGTGG  GTTGGAGGGA  CCTGTCTTGC  TGCTGTTACA  CGGTGGAGGC  180
181   CACTCTGCTC  TGTCCTGGGC  TGTGTTTACT  TCTGCAATCA  TTAGCAGGAT  CCAGTGTAGG  240
241   ATTGTGGCTT  TAGATCTCCG  AGGCCATGGA  GAAACAAAAG  TAAGGAATCC  TGAAGATCTG  300
301   TCTGCAGAGA  CTATGTCAAA  GGACGTGGGG  AGCGTGGTGG  AGGCGCTCTA  CGGGGACCTG  360
361   CCGCCGCCCA  TCATGCTGAT  CGGGCACAGC  ATGGGCGGCG  CCATCGCCGT  GCACACGGCC  420
421   GTCGCCAACC  TGGTGCCCAG  CCTGCTGGGG  CTCTGCATGA  TCGACGTCGT  GGAAGGTACG  480
481   GCCATGGATG  CCTTGAACAG  CATGCAGAAC  TTCCTAAGGA  GTCGGCCCAA  AACATTCAAG  540
541   TCACTTGAGA  ACGCCATTGA  GTGGAGTGTA  AAAAGTGGAC  AGATAAGAAA  TCTTGAATCT  600
601   GCCAGAGTTT  CTATGGTCGG  TCAAGTCAAA  CAGTGCGAAG  GGCCTGCCAG  TCCTGAATGC  660
661   CCTAAAGCCA  TAGTAGAGGG  AATTATTGAG  GAAGAGGAGG  AGGAGGAGGA  TGAGGATGAG  720
721   GAAGGGGGAG  GCTCTGTCAA  CAAAAGGAAG  AAAGAGGATG  ACACGGAGAT  AAAGAAGGAG  780
781   CATTTGTACA  CGTGGCGGAT  CGAACTGGCC  AAAACAGAAA  AGTACTGGGA  TGGCTGGTTC  840
841   AGGGGTTTAT  CCAACCTCTT  CCTGAGCTGT  CCGACTCCAA  AGCTTTTGCT  TTTAGCTGGT  900
901   GTTGACAGGC  TGGATAAAGA  TCTGACCATT  GGACAGATGC  AAGGGAAGTT  CCAGATGCAG  960
961   GTCCTCCCAC  AGTGTGGCCA  CGCGGTCCAT  GAAGACGCCC  CGGACAAGGT  TGCTGAAGCT  1020
1021  GTTGCAACGT  TCCTGATCCG  TCACAGGTTT  ACAGAGCCCA  TTGGTGGATT  CCAGTGTGTG  1080
1081  TTTCCTGCTT  GTTAA  1095

▼ KEYWORD

ID
Family
Complete proteome
Hydrolase
Reference proteome
Serine esterase

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Protein C-terminal methylesterase activity
Molecular Function
Protein phosphatase 2A binding
Biological Process
Protein demethylation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Anp-0271Anas platyrhynchos96.870.0 635
LLPS-Gaga-3614Gallus gallus96.630.0 644
LLPS-Meg-1344Meleagris gallopavo95.80.0 640
LLPS-Tag-2743Taeniopygia guttata94.00.0 608
LLPS-Pes-2942Pelodiscus sinensis91.140.0 606
LLPS-Ora-2803Ornithorhynchus anatinus91.110.0 617
LLPS-Bot-4341Bos taurus90.00.0 587
LLPS-Caf-4217Canis familiaris89.710.0 585
LLPS-Fec-2828Felis catus89.610.0 598
LLPS-Dio-4042Dipodomys ordii89.610.0 598
LLPS-Eqc-0585Equus caballus89.540.0 540
LLPS-Mup-1367Mustela putorius furo89.330.0 597
LLPS-Mum-3703Mus musculus89.330.0 598
LLPS-Poa-3701Pongo abelii89.040.0 596
LLPS-Rhb-0194Rhinopithecus bieti89.040.0 596
LLPS-Pap-4222Pan paniscus89.040.0 596
LLPS-Aim-2094Ailuropoda melanoleuca89.040.0 600
LLPS-Ran-3833Rattus norvegicus89.040.0 596
LLPS-Gog-4263Gorilla gorilla89.040.0 596
LLPS-Mea-3798Mesocricetus auratus89.040.0 595
LLPS-Chs-3198Chlorocebus sabaeus88.920.0 536
LLPS-Fud-3068Fukomys damarensis88.80.0 595
LLPS-Ict-3903Ictidomys tridecemlineatus88.760.0 595
LLPS-Cap-0906Cavia porcellus88.760.0 594
LLPS-Mod-0188Monodelphis domestica88.490.0 606
LLPS-Caj-3747Callithrix jacchus88.480.0 539
LLPS-Ova-4137Ovis aries88.190.0 589
LLPS-Otg-0269Otolemur garnettii88.020.0 586
LLPS-Sah-1650Sarcophilus harrisii87.640.0 577
LLPS-Aon-3972Aotus nancymaae87.432e-89 279
LLPS-Mam-3992Macaca mulatta87.20.0 518
LLPS-Orc-0997Oryctolagus cuniculus86.80.0 604
LLPS-Myl-0410Myotis lucifugus86.350.0 590
LLPS-Pat-0680Pan troglodytes85.680.0 586
LLPS-Hos-1939Homo sapiens85.680.0 586
LLPS-Paa-3262Papio anubis85.680.0 586
LLPS-Mal-1418Mandrillus leucophaeus85.680.0 587
LLPS-Loa-3544Loxodonta africana85.470.0 576
LLPS-Cas-2062Carlito syrichta85.410.0 578
LLPS-Anc-1803Anolis carolinensis84.431e-114 339
LLPS-Xet-3894Xenopus tropicalis83.80.0 586
LLPS-Man-4064Macaca nemestrina82.932e-166 478
LLPS-Cea-4172Cercocebus atys82.932e-166 478
LLPS-Maf-4716Macaca fascicularis82.932e-166 478
LLPS-Leo-0855Lepisosteus oculatus82.350.0 555
LLPS-Lac-3594Latimeria chalumnae81.62e-125 370
LLPS-Asm-3274Astyanax mexicanus80.580.0 520
LLPS-Dar-2405Danio rerio80.110.0 522
LLPS-Scf-2262Scleropages formosus80.110.0 553
LLPS-Sus-3443Sus scrofa79.332e-172 492
LLPS-Urm-4014Ursus maritimus78.213e-171 489
LLPS-Xim-2679Xiphophorus maculatus77.780.0 521
LLPS-Icp-2976Ictalurus punctatus77.460.0 525
LLPS-Pof-3479Poecilia formosa77.161e-165 473
LLPS-Nol-3526Nomascus leucogenys76.440.0 519
LLPS-Orn-0807Oreochromis niloticus76.350.0 514
LLPS-Tar-1490Takifugu rubripes76.070.0 517
LLPS-Scm-3675Scophthalmus maximus75.780.0 518
LLPS-Gaa-1819Gasterosteus aculeatus75.780.0 515
LLPS-Ten-2231Tetraodon nigroviridis75.281e-178 508
LLPS-Orl-1161Oryzias latipes75.210.0 514
LLPS-Phn-0323Phaeosphaeria nodorum59.33e-27 114
LLPS-Miv-0300Microbotryum violaceum54.931e-0959.7
LLPS-Orr-1434Oryza rufipogon51.721e-2197.4
LLPS-Orp-2204Oryza punctata51.722e-2197.1
LLPS-Orgl-2359Oryza glumaepatula51.721e-2197.4
LLPS-Orni-2096Oryza nivara51.721e-2197.8
LLPS-Orb-0671Oryza barthii51.722e-2197.1
LLPS-Cii-2243Ciona intestinalis51.473e-57 192
LLPS-Cis-0855Ciona savignyi50.293e-105 320
LLPS-Drm-1337Drosophila melanogaster47.245e-103 317
LLPS-Hea-1642Helianthus annuus46.735e-86 271
LLPS-Coc-0635Corchorus capsularis46.433e-85 270
LLPS-Viv-0868Vitis vinifera46.152e-86 272
LLPS-Gor-1524Gossypium raimondii46.131e-83 265
LLPS-Met-2365Medicago truncatula46.134e-85 268
LLPS-Mae-0379Manihot esculenta45.861e-84 268
LLPS-Pot-0977Populus trichocarpa45.585e-88 276
LLPS-Prp-0686Prunus persica45.544e-82 261
LLPS-Art-2780Arabidopsis thaliana45.41e-82 262
LLPS-Dac-0268Daucus carota45.322e-71 234
LLPS-Phv-2543Phaseolus vulgaris45.276e-85 268
LLPS-Cus-2016Cucumis sativus45.247e-83 263
LLPS-Amt-1178Amborella trichopoda44.946e-81 259
LLPS-Nia-2363Nicotiana attenuata44.838e-74 237
LLPS-Bro-2497Brassica oleracea44.642e-81 259
LLPS-Orbr-2299Oryza brachyantha44.644e-81 258
LLPS-Brr-2302Brassica rapa44.644e-82 261
LLPS-Tra-2021Triticum aestivum44.647e-82 260
LLPS-Lep-0171Leersia perrieri44.643e-82 261
LLPS-Cae-0450Caenorhabditis elegans44.644e-90 282
LLPS-Brn-2484Brassica napus44.644e-82 261
LLPS-Org-0973Oryza glaberrima44.353e-81 258
LLPS-Sob-1084Sorghum bicolor44.359e-81 257
LLPS-Brd-0155Brachypodium distachyon44.354e-79 254
LLPS-Mua-1542Musa acuminata44.082e-82 261
LLPS-Sol-1025Solanum lycopersicum44.084e-79 254
LLPS-Ors-1147Oryza sativa44.052e-81 259
LLPS-Arl-2040Arabidopsis lyrata44.051e-81 259
LLPS-Ori-1347Oryza indica44.052e-81 258
LLPS-Glm-0367Glycine max43.918e-81 258
LLPS-Php-2330Physcomitrella patens43.771e-73 241
LLPS-Thc-2397Theobroma cacao43.566e-81 259
LLPS-Sei-1834Setaria italica43.454e-79 253
LLPS-Sem-1991Selaginella moellendorffii42.773e-76 245
LLPS-Zem-1972Zea mays42.656e-77 248
LLPS-Via-1211Vigna angularis41.332e-78 254
LLPS-Vir-1860Vigna radiata41.076e-61 206
LLPS-Orm-0496Oryza meridionalis40.771e-66 219
LLPS-Tru-1761Triticum urartu39.718e-67 221
LLPS-Cym-0999Cyanidioschyzon merolae39.542e-66 223
LLPS-Asc-0697Aspergillus clavatus39.222e-52 185
LLPS-Scp-1583Schizosaccharomyces pombe38.911e-59 202
LLPS-Spr-0870Sporisorium reilianum38.87e-53 187
LLPS-Ved-0469Verticillium dahliae38.463e-59 203
LLPS-Mao-0856Magnaporthe oryzae38.449e-60 205
LLPS-Usm-1484Ustilago maydis38.397e-57 198
LLPS-Asn-0466Aspergillus nidulans37.542e-50 179
LLPS-Aso-1046Aspergillus oryzae37.57e-25 104
LLPS-Scs-0900Sclerotinia sclerotiorum37.49e-62 209
LLPS-Tum-1402Tuber melanosporum37.399e-61 207
LLPS-Asfu-0902Aspergillus fumigatus37.233e-51 182
LLPS-Cogr-0359Colletotrichum graminicola36.744e-57 197
LLPS-Fus-0820Fusarium solani36.672e-56 195
LLPS-Nef-1168Neosartorya fischeri36.527e-53 186
LLPS-Pytr-1341Pyrenophora triticirepentis36.391e-50 179
LLPS-Pyt-1195Pyrenophora teres36.396e-51 180
LLPS-Mel-1306Melampsora laricipopulina36.128e-52 182
LLPS-Fuo-1019Fusarium oxysporum36.114e-56 194
LLPS-Coo-1565Colletotrichum orbiculare36.112e-55 193
LLPS-Yal-0043Yarrowia lipolytica36.032e-52 186
LLPS-Crn-0701Cryptococcus neoformans36.01e-45 167
LLPS-Fuv-1246Fusarium verticillioides35.835e-55 192
LLPS-Asni-0998Aspergillus niger35.568e-50 178
LLPS-Gas-0665Galdieria sulphuraria35.511e-63 214
LLPS-Osl-0943Ostreococcus lucimarinus35.51e-54 187
LLPS-Trv-1468Trichoderma virens35.473e-55 192
LLPS-Nec-0458Neurospora crassa35.372e-60 208
LLPS-Scj-0538Schizosaccharomyces japonicus35.332e-54 189
LLPS-Chc-0394Chondrus crispus35.287e-50 177
LLPS-Put-1184Puccinia triticina35.236e-51 180
LLPS-Lem-0249Leptosphaeria maculans35.216e-51 180
LLPS-Trr-0539Trichoderma reesei35.24e-55 192
LLPS-Ast-0492Aspergillus terreus35.182e-53 187
LLPS-Beb-1095Beauveria bassiana35.185e-60 205
LLPS-Zyt-1371Zymoseptoria tritici34.674e-42 156
LLPS-Abg-1146Absidia glauca34.491e-48 173
LLPS-Scc-1555Schizosaccharomyces cryophilus34.252e-50 178
LLPS-Gag-0311Gaeumannomyces graminis34.09e-53 187
LLPS-Pug-1316Puccinia graminis33.825e-1679.3
LLPS-Chr-1007Chlamydomonas reinhardtii33.666e-53 187
LLPS-Blg-1235Blumeria graminis33.052e-53 187
LLPS-Dos-1472Dothistroma septosporum32.211e-45 166
LLPS-Kop-0797Komagataella pastoris32.083e-41 155
LLPS-Asg-0981Ashbya gossypii31.81e-34 136
LLPS-Asf-0440Aspergillus flavus28.463e-32 130
LLPS-Cog-1197Colletotrichum gloeosporioides28.016e-27 113
LLPS-Sac-1047Saccharomyces cerevisiae27.41e-25 110