• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aim-4077
NEFL

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Uncharacterized protein
Gene Name: NEFL
Ensembl Gene: ENSAMEG00000000584.1
Ensembl Protein: ENSAMEP00000000616.1
Organism: Ailuropoda melanoleuca
Taxa ID: 9646
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PML nuclear body, Postsynaptic densityPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSFSYEPYY  STSYKRRYVE  TPRVHISSVR  SGYSTARSAY  SSYSAPVSSS  LSVRRSYSSS  60
61    SGSLMPSLEN  LDLSQVAAIS  NDLKSIRTQE  KAQLQDLNDR  FASFIERVHE  LEQQNKVLEA  120
121   ELLVLRQKHS  EPSRFRALYE  QEIRDLRLAA  EDATNEKQAL  QGEREGLEET  LRNLQARYEE  180
181   EVLSREDAEG  RLMEARKGAD  EAALARAELE  KRIDSLMDEI  AFLKKVHEEE  IAELQAQIQY  240
241   AQISVEMDVS  SKPDLSAALK  DIRAQYEKLA  AKNMQNAEEW  FKSRFTVLTE  SAAKNTDAVR  300
301   AAKDEVSESR  RLLKAKTLEI  EACRGMNEAL  EKQLQELEDK  QNADISAMQD  TINKLENELR  360
361   TTKSEMARYL  KEYQDLLNVK  MALDIEIAAY  RKLLEGEETR  LSFTSVGSIT  SGYSQSSQVF  420
421   GRSAYGGLQT  SSYLMSARSF  PSYYTSHVQE  EQIEVEETIE  AAKAEEAKDE  PASEGEAEEE  480
481   EKEKEEAAEE  EGAEEEEAAK  EESEEAKEEE  EGGEGEEGEE  TKEAEEEEKK  DDGAGEEQAT  540
541   KKKD  544
Nucleotide CDS Sequence (FASTA)
1     ATGAGTTCCT  TCAGCTACGA  GCCGTACTAC  TCGACCTCCT  ACAAGCGGCG  CTACGTGGAG  60
61    ACGCCCCGGG  TGCACATCTC  CAGCGTGCGC  AGCGGCTACA  GCACCGCGCG  CTCCGCTTAC  120
121   TCCAGCTACT  CCGCGCCGGT  CTCCTCCTCG  CTGTCCGTGC  GCCGAAGCTA  CTCCTCCAGC  180
181   TCCGGCTCCT  TGATGCCCAG  TCTCGAGAAC  CTCGACCTGA  GCCAGGTAGC  CGCTATCAGC  240
241   AACGACCTCA  AGTCAATCCG  CACCCAGGAG  AAAGCGCAGC  TGCAGGACCT  CAACGACCGC  300
301   TTCGCCAGCT  TCATCGAGCG  CGTGCACGAG  CTGGAGCAGC  AGAACAAGGT  GCTGGAAGCC  360
361   GAGCTGCTGG  TGCTGCGCCA  GAAGCACTCC  GAGCCCTCCC  GCTTCCGGGC  GCTGTACGAG  420
421   CAGGAGATCC  GCGACCTGCG  CCTGGCGGCG  GAAGACGCCA  CCAACGAGAA  GCAGGCACTC  480
481   CAGGGCGAGC  GCGAAGGGCT  GGAGGAGACT  TTGCGCAACC  TGCAGGCGCG  CTATGAAGAG  540
541   GAGGTGCTGA  GCCGCGAGGA  CGCCGAGGGC  CGGCTGATGG  AAGCGCGCAA  AGGAGCCGAC  600
601   GAGGCCGCTC  TCGCCCGCGC  CGAGCTCGAA  AAACGCATTG  ACAGCCTGAT  GGACGAAATC  660
661   GCCTTTCTGA  AGAAAGTGCA  CGAAGAGGAG  ATCGCCGAGC  TGCAGGCGCA  GATCCAGTAC  720
721   GCTCAGATCT  CCGTGGAGAT  GGACGTGTCC  TCCAAGCCCG  ACCTCTCCGC  TGCGCTCAAG  780
781   GACATCCGTG  CTCAGTACGA  GAAGCTGGCT  GCCAAGAACA  TGCAGAACGC  CGAAGAGTGG  840
841   TTCAAGAGCC  GCTTCACGGT  GCTGACCGAG  AGCGCCGCCA  AGAACACCGA  CGCGGTGCGC  900
901   GCCGCCAAGG  ACGAGGTGTC  CGAGAGCCGC  CGCCTGCTCA  AGGCCAAGAC  CCTGGAGATC  960
961   GAAGCATGCC  GGGGCATGAA  CGAAGCGCTG  GAGAAGCAGC  TGCAGGAGCT  GGAGGACAAG  1020
1021  CAGAACGCCG  ATATTAGTGC  TATGCAGGAC  ACAATCAACA  AATTAGAAAA  TGAATTGCGA  1080
1081  ACCACGAAGA  GTGAAATGGC  ACGATACCTT  AAAGAATACC  AAGACCTCCT  CAATGTGAAG  1140
1141  ATGGCTTTGG  ACATTGAGAT  TGCAGCTTAT  AGGAAACTCT  TGGAGGGTGA  GGAGACCCGG  1200
1201  CTCAGTTTTA  CCAGCGTGGG  AAGCATAACC  AGCGGCTACT  CCCAGAGCTC  TCAGGTCTTT  1260
1261  GGCCGATCTG  CCTATGGTGG  GTTACAGACC  AGCTCCTACT  TGATGTCTGC  CCGCTCCTTC  1320
1321  CCGTCTTATT  ACACCAGCCA  CGTCCAGGAG  GAGCAGATCG  AGGTGGAGGA  GACCATTGAG  1380
1381  GCTGCAAAGG  CCGAGGAAGC  CAAGGACGAA  CCTGCCTCTG  AAGGAGAAGC  CGAGGAGGAG  1440
1441  GAGAAGGAGA  AGGAAGAGGC  TGCTGAAGAG  GAAGGAGCTG  AAGAGGAAGA  AGCTGCCAAG  1500
1501  GAAGAATCTG  AGGAGGCAAA  GGAGGAAGAG  GAAGGAGGTG  AAGGCGAAGA  AGGAGAAGAA  1560
1561  ACCAAAGAAG  CCGAGGAGGA  GGAGAAAAAA  GATGACGGTG  CTGGGGAGGA  ACAAGCAACT  1620
1621  AAAAAGAAAG  ATTGA  1635

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Caf-3628Canis familiaris100.00.0 731
LLPS-Fec-3435Felis catus100.00.0 730
LLPS-Urm-4035Ursus maritimus100.00.0 730
LLPS-Mam-4564Macaca mulatta99.550.0 723
LLPS-Man-3425Macaca nemestrina99.550.0 723
LLPS-Mup-3164Mustela putorius furo99.550.0 729
LLPS-Mal-0741Mandrillus leucophaeus99.550.0 723
LLPS-Paa-0983Papio anubis99.550.0 723
LLPS-Chs-2623Chlorocebus sabaeus99.550.0 721
LLPS-Maf-0843Macaca fascicularis99.550.0 723
LLPS-Cap-4061Cavia porcellus99.330.0 721
LLPS-Caj-4509Callithrix jacchus99.330.0 729
LLPS-Cea-4295Cercocebus atys99.330.0 720
LLPS-Sus-1788Sus scrofa99.330.0 724
LLPS-Nol-0953Nomascus leucogenys99.110.0 721
LLPS-Eqc-2587Equus caballus99.110.0 727
LLPS-Poa-1190Pongo abelii99.110.0 720
LLPS-Pap-3665Pan paniscus99.110.0 720
LLPS-Pat-4130Pan troglodytes99.110.0 720
LLPS-Hos-2703Homo sapiens99.110.0 720
LLPS-Tut-0250Tursiops truncatus99.110.0 723
LLPS-Bot-3887Bos taurus99.110.0 726
LLPS-Gog-0807Gorilla gorilla99.110.0 720
LLPS-Aon-3112Aotus nancymaae99.110.0 727
LLPS-Otg-2049Otolemur garnettii98.950.0 585
LLPS-Ran-2337Rattus norvegicus98.660.0 721
LLPS-Fud-3916Fukomys damarensis98.660.0 724
LLPS-Mum-4808Mus musculus98.430.0 719
LLPS-Dio-4307Dipodomys ordii97.990.0 686
LLPS-Rhb-2567Rhinopithecus bieti97.760.0 705
LLPS-Mea-0340Mesocricetus auratus97.411e-92 290
LLPS-Mod-1146Monodelphis domestica96.394e-177 514
LLPS-Ict-2522Ictidomys tridecemlineatus91.720.0 641
LLPS-Gaga-2241Gallus gallus91.280.0 556
LLPS-Loa-2430Loxodonta africana89.040.0 607
LLPS-Myl-0998Myotis lucifugus87.444e-120 365
LLPS-Orc-1186Oryctolagus cuniculus86.370.0 619
LLPS-Pes-3726Pelodiscus sinensis85.582e-158 466
LLPS-Fia-3450Ficedula albicollis82.180.0 632
LLPS-Meg-2687Meleagris gallopavo82.180.0 637
LLPS-Lac-2411Latimeria chalumnae77.130.0 581
LLPS-Ora-1407Ornithorhynchus anatinus76.480.0 541
LLPS-Anc-2290Anolis carolinensis75.582e-168 497
LLPS-Xet-3040Xenopus tropicalis72.540.0 557
LLPS-Tag-2936Taeniopygia guttata72.440.0 532
LLPS-Leo-0978Lepisosteus oculatus70.751e-164 488
LLPS-Dar-3796Danio rerio64.021e-135 413
LLPS-Orn-3665Oreochromis niloticus61.847e-129 395
LLPS-Scm-2631Scophthalmus maximus60.888e-122 379
LLPS-Tar-0482Takifugu rubripes59.512e-117 364
LLPS-Pof-1602Poecilia formosa59.432e-122 378
LLPS-Ten-1584Tetraodon nigroviridis59.369e-112 343
LLPS-Xim-3822Xiphophorus maculatus58.295e-120 372
LLPS-Icp-2948Ictalurus punctatus57.537e-129 393
LLPS-Gaa-2366Gasterosteus aculeatus56.395e-133 409
LLPS-Asm-0359Astyanax mexicanus55.972e-132 406
LLPS-Orl-1697Oryzias latipes55.974e-132 407
LLPS-Sah-1064Sarcophilus harrisii55.953e-61 209
LLPS-Ova-3519Ovis aries54.032e-86 282
LLPS-Cas-0203Carlito syrichta51.941e-87 285
LLPS-Ere-0443Erinaceus europaeus51.946e-88 286
LLPS-Scf-3368Scleropages formosus51.53e-85 278
LLPS-Anp-0298Anas platyrhynchos49.854e-81 268
LLPS-Cii-0131Ciona intestinalis42.123e-60 214
LLPS-Cis-0564Ciona savignyi37.62e-57 206