• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aim-2853
SRP68

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Signal recognition particle subunit SRP68
Gene Name: SRP68
Ensembl Gene: ENSAMEG00000010078.1
Ensembl Protein: ENSAMEP00000010625.1
Organism: Ailuropoda melanoleuca
Taxa ID: 9646
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAEKQVPGG  GGGGGGGSGW  SPRGGAGGEE  NKENERPSAG  SKANKEFGDS  LSLEILQIIK  60
61    ESQQQHGLRH  GDFQRYRGYC  SRRQRRLRKT  LNFKMGNRHK  FIGKKVTEDL  LTDNRYLLLV  120
121   LMDAERAWSY  AMQLKQEANT  EPRKRFHLLS  RLRKAVKHAE  ELERLCESNR  VDAKTKLEAQ  180
181   AYTAYLSGML  RFEHQEWKAA  IEAFNKCKTI  YEKLASAFTE  EQAVLYNQRV  EEISPNIRYC  240
241   AYNIGDQSAI  NELMQMRLRS  GGTEGLLAEK  LEALITQTRA  KQAATMSEVE  WRGRTVPVKI  300
301   DKVRIFLLGL  ADNEAAVAQA  ESEETKERLF  ESMLSECRDA  IQAVREELKP  DQKQRDYTLD  360
361   GESGKVSNLQ  YLHSYLTYIK  LSTAIRRNEN  MAKGLQKALQ  QQPEDDSKRS  PRPQDLIRLY  420
421   DIILQNLVEL  LQLPGLEEDR  AFQKEIGLKT  LVFKAYRCFF  IAQSYVLVKK  WSEALVLYDR  480
481   VLKYANEVNS  DAGAFRNSLK  DLPDVQELIT  QVRSEKCSLQ  AAAILDASDS  HQTETSSQVK  540
541   DNKPLVERFE  TFCLDPSLVT  KQANLVHFPP  GFQPIPCKPL  FFDLALNHVA  FPPLEDKLEQ  600
601   KTKSGLTGYI  KGIFGFRS  618
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGCCG  AGAAACAGGT  TCCCGGTGGC  GGCGGCGGCG  GCGGCGGCGG  CAGTGGCTGG  60
61    AGCCCCCGTG  GCGGTGCCGG  AGGAGAGGAA  AATAAGGAAA  ACGAACGGCC  TTCAGCTGGA  120
121   TCGAAGGCAA  ACAAAGAATT  CGGGGATAGC  CTGAGTTTGG  AGATTCTTCA  GATTATTAAG  180
181   GAATCCCAGC  AGCAGCATGG  TTTACGGCAT  GGAGATTTTC  AGAGGTATAG  GGGCTACTGT  240
241   TCCCGTAGAC  AAAGACGTCT  TCGGAAAACA  CTCAACTTCA  AGATGGGGAA  CAGACACAAA  300
301   TTTATAGGGA  AAAAAGTGAC  TGAAGATCTT  CTGACTGATA  ACAGGTATTT  GCTTCTGGTT  360
361   CTGATGGATG  CTGAGCGAGC  CTGGAGCTAT  GCCATGCAGC  TGAAACAGGA  AGCCAACACT  420
421   GAACCCCGGA  AACGGTTCCA  CTTGTTGTCT  CGCCTGCGCA  AAGCCGTGAA  GCACGCGGAG  480
481   GAATTGGAAC  GCTTGTGTGA  GAGCAATCGC  GTGGATGCCA  AGACCAAGTT  AGAGGCTCAG  540
541   GCTTACACCG  CTTACCTCTC  AGGAATGCTG  CGTTTTGAGC  ATCAAGAATG  GAAAGCTGCG  600
601   ATTGAGGCTT  TTAACAAATG  CAAAACTATC  TATGAGAAAC  TAGCCAGTGC  TTTCACAGAA  660
661   GAGCAGGCTG  TGCTGTACAA  CCAGCGTGTG  GAAGAGATCT  CACCCAATAT  CCGCTACTGT  720
721   GCATATAACA  TTGGGGACCA  GTCAGCTATC  AATGAACTCA  TGCAGATGAG  ATTGAGGTCT  780
781   GGGGGCACTG  AGGGTCTTCT  GGCTGAAAAA  TTGGAGGCGT  TGATCACTCA  GACTCGGGCC  840
841   AAACAGGCAG  CCACCATGAG  CGAAGTGGAA  TGGAGAGGGA  GAACGGTTCC  AGTGAAGATC  900
901   GACAAAGTGA  GGATCTTTTT  ATTGGGATTG  GCTGATAATG  AAGCAGCCGT  TGCCCAGGCT  960
961   GAAAGTGAGG  AAACCAAGGA  GCGTCTGTTT  GAATCCATGC  TCAGTGAGTG  TCGGGACGCC  1020
1021  ATCCAGGCCG  TTCGGGAAGA  GCTCAAGCCA  GATCAGAAAC  AGAGAGATTA  TACCCTTGAT  1080
1081  GGGGAGTCGG  GGAAGGTATC  TAATCTTCAA  TACCTGCACA  GCTACCTGAC  TTACATCAAG  1140
1141  CTGTCAACGG  CCATCAGGCG  GAACGAGAAC  ATGGCTAAGG  GGCTGCAGAA  AGCGCTGCAG  1200
1201  CAGCAGCCGG  AAGACGACAG  CAAGCGCTCC  CCACGGCCCC  AGGACCTCAT  CCGGCTGTAT  1260
1261  GACATCATTC  TGCAGAATCT  GGTGGAATTG  CTCCAGCTTC  CTGGCTTAGA  GGAGGACCGA  1320
1321  GCCTTCCAGA  AAGAGATAGG  CCTCAAGACG  CTGGTGTTTA  AGGCTTACAG  GTGTTTTTTC  1380
1381  ATTGCTCAGT  CCTACGTGTT  GGTGAAGAAG  TGGAGCGAAG  CCCTTGTCCT  GTATGACCGA  1440
1441  GTCCTGAAGT  ATGCAAACGA  AGTAAATTCT  GACGCCGGGG  CCTTCAGGAA  CAGCTTAAAG  1500
1501  GACCTGCCCG  ACGTGCAAGA  GCTCATCACG  CAAGTGAGGT  CAGAAAAGTG  TTCTCTGCAG  1560
1561  GCGGCAGCAA  TCCTGGATGC  AAGTGACTCC  CACCAAACGG  AGACTTCCTC  CCAAGTCAAG  1620
1621  GACAACAAGC  CTCTGGTCGA  ACGATTTGAG  ACATTCTGCC  TGGACCCTTC  CCTCGTCACC  1680
1681  AAGCAGGCCA  ACCTCGTACA  CTTCCCGCCT  GGATTCCAGC  CCATCCCTTG  CAAGCCTTTG  1740
1741  TTCTTTGACC  TGGCCCTCAA  CCACGTGGCT  TTCCCACCTC  TTGAGGACAA  GCTGGAGCAG  1800
1801  AAGACCAAGA  GTGGCCTCAC  TGGATACATC  AAGGGCATCT  TTGGGTTCAG  GAGCTAA  1857

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Reference proteome
Ribonucleoprotein
RNA-binding
Signal recognition particle

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Focal adhesion
Cellular Component
Signal recognition particle, endoplasmic reticulum targeting
Molecular Function
7S RNA binding
Molecular Function
Endoplasmic reticulum signal peptide binding
Molecular Function
Protein domain specific binding
Molecular Function
Ribosome binding
Molecular Function
Signal recognition particle binding
Biological Process
Response to drug
Biological Process
SRP-dependent cotranslational protein targeting to membrane

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-0624Ictidomys tridecemlineatus98.80.01154
LLPS-Mup-1548Mustela putorius furo98.630.01156
LLPS-Caf-2003Canis familiaris98.220.01165
LLPS-Caj-1726Callithrix jacchus97.950.01143
LLPS-Eqc-0400Equus caballus97.770.01144
LLPS-Rhb-2027Rhinopithecus bieti97.440.01138
LLPS-Mam-3715Macaca mulatta97.260.01137
LLPS-Orc-0067Oryctolagus cuniculus97.260.01141
LLPS-Hos-0753Homo sapiens97.260.01136
LLPS-Man-2871Macaca nemestrina97.260.01137
LLPS-Mal-0795Mandrillus leucophaeus97.260.01137
LLPS-Gog-1357Gorilla gorilla97.260.01136
LLPS-Cea-0834Cercocebus atys97.260.01137
LLPS-Paa-2964Papio anubis97.170.01097
LLPS-Bot-0473Bos taurus97.090.01135
LLPS-Fec-2917Felis catus96.930.01154
LLPS-Pat-0000Pan troglodytes96.920.01134
LLPS-Mea-2339Mesocricetus auratus96.920.01131
LLPS-Aon-2535Aotus nancymaae96.920.01127
LLPS-Cas-0255Carlito syrichta96.860.0 577
LLPS-Ova-0738Ovis aries96.580.01132
LLPS-Mum-0805Mus musculus96.40.01129
LLPS-Sus-3530Sus scrofa96.230.01127
LLPS-Chs-0639Chlorocebus sabaeus96.130.01142
LLPS-Loa-1911Loxodonta africana95.720.01120
LLPS-Ran-0993Rattus norvegicus95.720.01125
LLPS-Maf-0510Macaca fascicularis95.660.01138
LLPS-Pap-0103Pan paniscus95.650.01134
LLPS-Poa-2444Pongo abelii95.433e-133 396
LLPS-Cap-2125Cavia porcellus95.030.01109
LLPS-Fud-1908Fukomys damarensis94.520.01105
LLPS-Myl-0623Myotis lucifugus94.510.01132
LLPS-Otg-0106Otolemur garnettii91.810.01090
LLPS-Mod-1297Monodelphis domestica91.620.01000
LLPS-Dio-1615Dipodomys ordii90.750.01035
LLPS-Sah-0026Sarcophilus harrisii90.240.01057
LLPS-Fia-2401Ficedula albicollis89.160.0 980
LLPS-Pes-2137Pelodiscus sinensis88.780.0 972
LLPS-Meg-0218Meleagris gallopavo88.380.01018
LLPS-Tag-1648Taeniopygia guttata88.210.01019
LLPS-Gaga-2158Gallus gallus88.030.01040
LLPS-Anp-1971Anas platyrhynchos87.870.01018
LLPS-Nol-0481Nomascus leucogenys87.280.01025
LLPS-Xet-1776Xenopus tropicalis81.830.0 927
LLPS-Lac-0596Latimeria chalumnae80.550.0 922
LLPS-Leo-0474Lepisosteus oculatus79.820.0 911
LLPS-Scf-2229Scleropages formosus79.040.0 915
LLPS-Ora-0270Ornithorhynchus anatinus78.450.0 874
LLPS-Orn-2112Oreochromis niloticus77.540.0 876
LLPS-Icp-0286Ictalurus punctatus77.520.0 863
LLPS-Asm-2036Astyanax mexicanus77.230.0 880
LLPS-Ten-1406Tetraodon nigroviridis77.030.0 887
LLPS-Scm-1120Scophthalmus maximus76.740.0 880
LLPS-Tar-0339Takifugu rubripes76.60.0 847
LLPS-Pof-1740Poecilia formosa75.770.0 878
LLPS-Xim-0630Xiphophorus maculatus75.60.0 876
LLPS-Orl-2057Oryzias latipes75.60.0 878
LLPS-Gaa-0281Gasterosteus aculeatus75.260.0 870
LLPS-Dar-1171Danio rerio74.260.0 836
LLPS-Anc-0559Anolis carolinensis71.210.0 763
LLPS-Cii-0364Ciona intestinalis45.522e-167 498
LLPS-Cis-0770Ciona savignyi44.351e-163 489
LLPS-Drm-0332Drosophila melanogaster42.985e-138 422
LLPS-Chr-0751Chlamydomonas reinhardtii40.364e-37 150
LLPS-Php-1148Physcomitrella patens35.41e-84 284
LLPS-Glm-0847Glycine max34.123e-83 279
LLPS-Brr-0963Brassica rapa34.111e-84 283
LLPS-Amt-0375Amborella trichopoda34.015e-88 292
LLPS-Arl-0738Arabidopsis lyrata33.978e-85 284
LLPS-Brd-1686Brachypodium distachyon33.849e-81 273
LLPS-Bro-2135Brassica oleracea33.733e-83 280
LLPS-Brn-1218Brassica napus33.731e-83 280
LLPS-Mae-0861Manihot esculenta33.621e-87 291
LLPS-Tra-1516Triticum aestivum33.613e-79 269
LLPS-Hov-1908Hordeum vulgare33.561e-78 267
LLPS-Prp-0101Prunus persica33.51e-82 279
LLPS-Art-0012Arabidopsis thaliana33.452e-83 280
LLPS-Viv-1550Vitis vinifera33.393e-85 285
LLPS-Sob-1307Sorghum bicolor33.167e-80 270
LLPS-Met-0567Medicago truncatula33.161e-81 275
LLPS-Vir-0580Vigna radiata33.166e-82 276
LLPS-Via-0460Vigna angularis33.168e-82 276
LLPS-Mua-0555Musa acuminata33.114e-82 276
LLPS-Cus-1684Cucumis sativus32.945e-86 286
LLPS-Nia-0278Nicotiana attenuata32.843e-79 269
LLPS-Thc-0362Theobroma cacao32.842e-82 277
LLPS-Zem-1473Zea mays32.826e-81 273
LLPS-Sol-1749Solanum lycopersicum32.825e-78 265
LLPS-Hea-1907Helianthus annuus32.775e-73 252
LLPS-Gor-1072Gossypium raimondii32.682e-82 277
LLPS-Orbr-0962Oryza brachyantha32.63e-77 263
LLPS-Sei-1896Setaria italica32.66e-79 268
LLPS-Tru-0579Triticum urartu32.517e-64 228
LLPS-Phv-1505Phaseolus vulgaris32.51e-79 270
LLPS-Orp-0397Oryza punctata32.437e-80 270
LLPS-Cae-1670Caenorhabditis elegans32.189e-76 260
LLPS-Pot-1117Populus trichocarpa32.178e-77 263
LLPS-Orm-0705Oryza meridionalis32.096e-77 262
LLPS-Orgl-0278Oryza glumaepatula32.091e-76 261
LLPS-Abg-0677Absidia glauca31.973e-77 263
LLPS-Orb-0087Oryza barthii31.934e-76 260
LLPS-Dac-0224Daucus carota31.821e-71 248
LLPS-Orr-0568Oryza rufipogon31.582e-75 258
LLPS-Zyt-0689Zymoseptoria tritici30.842e-1170.9
LLPS-Sot-1310Solanum tuberosum30.463e-61 217
LLPS-Orni-0525Oryza nivara30.384e-72 249
LLPS-Sem-0017Selaginella moellendorffii30.365e-63 223
LLPS-Ori-1885Oryza indica30.325e-60 216
LLPS-Chc-0780Chondrus crispus29.295e-43 164
LLPS-Lem-0822Leptosphaeria maculans28.649e-1682.4
LLPS-Gas-0856Galdieria sulphuraria28.553e-51 191
LLPS-Lep-1544Leersia perrieri27.972e-30 129
LLPS-Spr-1305Sporisorium reilianum27.483e-1067.8
LLPS-Tum-0098Tuber melanosporum27.432e-30 129
LLPS-Put-0013Puccinia triticina27.44e-1685.5
LLPS-Osl-0194Ostreococcus lucimarinus27.333e-26 117
LLPS-Ved-0726Verticillium dahliae27.047e-38 152
LLPS-Beb-0312Beauveria bassiana26.668e-37 149
LLPS-Ors-0314Oryza sativa26.43e-40 157
LLPS-Mao-0516Magnaporthe oryzae26.311e-38 154
LLPS-Pug-0716Puccinia graminis26.151e-1481.3
LLPS-Cog-0902Colletotrichum gloeosporioides26.011e-39 157
LLPS-Dos-0747Dothistroma septosporum25.971e-29 128
LLPS-Nef-0957Neosartorya fischeri25.86e-37 149
LLPS-Cogr-0380Colletotrichum graminicola25.792e-37 150
LLPS-Asn-1342Aspergillus nidulans25.63e-31 133
LLPS-Ast-0305Aspergillus terreus25.511e-35 145
LLPS-Coo-1021Colletotrichum orbiculare25.56e-34 140
LLPS-Asni-0974Aspergillus niger25.469e-33 137
LLPS-Pytr-0057Pyrenophora triticirepentis25.413e-34 142
LLPS-Blg-0495Blumeria graminis25.353e-35 144
LLPS-Aso-0789Aspergillus oryzae25.212e-35 145
LLPS-Asfu-0066Aspergillus fumigatus25.093e-35 145
LLPS-Nec-0791Neurospora crassa25.082e-31 134
LLPS-Asc-0169Aspergillus clavatus25.043e-35 144
LLPS-Usm-0811Ustilago maydis25.01e-1378.6
LLPS-Asf-0385Aspergillus flavus24.872e-35 145
LLPS-Fus-0570Fusarium solani24.831e-35 145
LLPS-Pyt-0788Pyrenophora teres24.781e-31 134
LLPS-Gag-1016Gaeumannomyces graminis24.686e-32 135
LLPS-Map-0706Magnaporthe poae24.413e-30 130
LLPS-Trr-0491Trichoderma reesei24.41e-28 125
LLPS-Scc-0284Schizosaccharomyces cryophilus24.286e-25 113
LLPS-Miv-0365Microbotryum violaceum24.115e-22 105
LLPS-Scs-0036Sclerotinia sclerotiorum24.091e-1996.7
LLPS-Phn-0207Phaeosphaeria nodorum24.052e-22 105
LLPS-Fuo-1160Fusarium oxysporum24.026e-31 132
LLPS-Fuv-0548Fusarium verticillioides23.822e-33 139
LLPS-Scj-0692Schizosaccharomyces japonicus23.711e-1172.0
LLPS-Trv-0263Trichoderma virens23.689e-30 128
LLPS-Yal-1031Yarrowia lipolytica23.662e-24 112
LLPS-Crn-0279Cryptococcus neoformans23.585e-1479.3
LLPS-Scp-0785Schizosaccharomyces pombe23.152e-1583.6
LLPS-Mel-0142Melampsora laricipopulina21.74e-22 105
LLPS-Kop-1424Komagataella pastoris21.21e-1068.6