• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aim-1322
PKLR

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Pyruvate kinase
Gene Name: PKLR
Ensembl Gene: ENSAMEG00000000055.1
Ensembl Protein: ENSAMEP00000000060.1
Organism: Ailuropoda melanoleuca
Taxa ID: 9646
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSAMET00000000062.1ENSAMEP00000000060.1
UniProtG1KZL2, G1KZL2_AILME
GeneBankACTA01050641, ACTA01058641

▼ SEQUENCE

Protein Sequence (FASTA)
1     SSLPVSTASH  FVSMSSQESI  QAQELWSRIS  KSQRDLAKSI  LIGAPGGPAG  YLRRASVAQL  60
61    THELGTAFLQ  RQQLSAAMAD  SFLEHLCLLD  IDSEPVAARS  TSIIATIGPA  SHSVERLKEM  120
121   IKAGMNIARL  NFSPSCPQYH  AQSIANIREA  VESFATSPLG  YRPVAIALDT  KGPEIRTGVL  180
181   QGGPEAEVEL  VKGSRVLVTV  DPAFRTRGNA  NTVWVDYPNI  VKVVPVGGRI  YIDDGLISLQ  240
241   VKKIGPEGLE  TQVENGGLLG  SRKGVNLPGA  EVDLPGLSEQ  DVLDLRFGVQ  HNVDIVFASF  300
301   VRKASDVATI  RAALGPEGRN  IKIISKIENH  EGVKKFDEIL  EVSDGIMVAR  GDLGIEIPAE  360
361   KVFLAQKMMI  GRCNLAGKPV  VCATQMLESM  ITKPRPTRAE  TSDVANAVLD  GADCIMLSGE  420
421   TAKGRFPVEA  VKMQHAIARE  AEAAVYHRQL  FEELRRAAPL  SRDPTEVTAI  GAVEAAFKCC  480
481   AAAIIVLTTT  GRSAQLLSRY  RPRAAVIAVT  RSAQAARQAH  LCRGVFPLLY  SETPEAIWAD  540
541   DVDRRVQFGI  ESGKLRGFLR  VGDLVIVVTG  WRPGSGYTNI  MRVLSVS  587
Nucleotide CDS Sequence (FASTA)
1     TCCTCTCTCC  CTGTCTCCAC  AGCCTCTCAC  TTTGTAAGCA  TGTCCAGCCA  GGAGAGCATA  60
61    CAAGCCCAGG  AGCTTTGGTC  AAGGATCTCT  AAGTCCCAAA  GGGACTTAGC  AAAGTCCATC  120
121   CTGATTGGGG  CTCCAGGAGG  GCCGGCGGGG  TACCTGAGGC  GGGCCAGCGT  GGCCCAGCTG  180
181   ACCCACGAGC  TGGGCACGGC  CTTCCTCCAG  CGGCAGCAGC  TGTCGGCTGC  TATGGCAGAC  240
241   AGCTTCCTGG  AGCACCTGTG  CCTCCTGGAC  ATCGACTCGG  AGCCCGTGGC  CGCCCGCAGT  300
301   ACCAGCATCA  TTGCCACCAT  CGGGCCGGCT  TCTCACTCGG  TGGAGCGCCT  CAAGGAGATG  360
361   ATCAAAGCGG  GGATGAACAT  TGCGCGCCTC  AACTTCTCCC  CCTCTTGTCC  CCAGTACCAC  420
421   GCTCAGTCCA  TCGCCAACAT  CCGGGAGGCG  GTGGAGAGCT  TTGCAACTTC  TCCCCTCGGC  480
481   TACCGACCCG  TGGCCATCGC  CCTGGACACC  AAGGGACCGG  AGATACGCAC  CGGAGTCCTG  540
541   CAGGGGGGCC  CGGAGGCCGA  GGTGGAGCTA  GTGAAGGGCT  CCCGGGTGCT  GGTGACCGTG  600
601   GACCCGGCGT  TCCGGACAAG  AGGGAACGCG  AACACCGTGT  GGGTGGACTA  CCCCAATATC  660
661   GTGAAGGTCG  TGCCGGTGGG  GGGCCGCATC  TACATAGACG  ACGGGCTCAT  CTCCCTCCAG  720
721   GTCAAGAAAA  TCGGCCCGGA  GGGGCTGGAG  ACCCAAGTGG  AGAACGGAGG  CCTCCTGGGC  780
781   AGCCGGAAGG  GCGTGAACTT  ACCAGGCGCT  GAGGTGGACT  TGCCCGGGCT  GTCCGAGCAA  840
841   GACGTCCTGG  ACTTGCGCTT  CGGGGTGCAG  CATAATGTGG  ACATCGTCTT  TGCCTCCTTC  900
901   GTGCGGAAAG  CCAGTGACGT  GGCTACCATC  CGGGCTGCTC  TGGGGCCTGA  AGGACGAAAC  960
961   ATCAAGATCA  TTAGCAAAAT  CGAGAACCAC  GAAGGCGTGA  AGAAGTTTGA  TGAAATCCTG  1020
1021  GAGGTGAGCG  ATGGCATCAT  GGTGGCACGG  GGCGACCTGG  GCATCGAGAT  CCCAGCCGAG  1080
1081  AAGGTTTTCC  TGGCCCAGAA  GATGATGATC  GGACGGTGCA  ACTTGGCGGG  CAAGCCCGTC  1140
1141  GTCTGCGCCA  CACAGATGCT  GGAGAGCATG  ATCACAAAGC  CGCGGCCGAC  CCGGGCAGAG  1200
1201  ACGAGTGACG  TAGCCAACGC  CGTGCTGGAT  GGAGCCGACT  GCATCATGCT  GTCGGGGGAA  1260
1261  ACTGCCAAGG  GCCGATTTCC  CGTGGAGGCA  GTGAAGATGC  AGCACGCGAT  CGCCCGGGAG  1320
1321  GCGGAGGCTG  CTGTGTACCA  CCGGCAGCTG  TTTGAGGAAC  TGCGCCGGGC  AGCGCCCCTG  1380
1381  AGCCGCGATC  CCACTGAGGT  CACTGCCATA  GGTGCGGTGG  AGGCCGCCTT  CAAGTGCTGT  1440
1441  GCTGCTGCCA  TCATCGTGCT  GACCACGACT  GGCCGCTCAG  CACAGCTGCT  GTCTCGGTAC  1500
1501  CGACCTCGGG  CAGCAGTCAT  TGCTGTCACC  CGCTCTGCCC  AGGCTGCTCG  GCAGGCCCAC  1560
1561  CTGTGCCGAG  GGGTCTTCCC  TTTGCTCTAC  AGTGAAACTC  CAGAGGCCAT  CTGGGCAGAC  1620
1621  GACGTGGATC  GCCGGGTCCA  ATTTGGCATT  GAAAGCGGAA  AGCTCCGTGG  CTTCCTCCGC  1680
1681  GTGGGGGACC  TGGTGATCGT  GGTGACAGGC  TGGCGACCTG  GCTCTGGCTA  CACCAACATC  1740
1741  ATGCGAGTGC  TGAGCGTCTC  CTGA  1764

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mup-1271Mustela putorius furo95.120.01074
LLPS-Caf-1866Canis familiaris94.20.01083
LLPS-Poa-4096Pongo abelii93.980.0 697
LLPS-Man-2235Macaca nemestrina92.790.0 988
LLPS-Mam-3518Macaca mulatta92.610.0 986
LLPS-Chs-4469Chlorocebus sabaeus92.520.0 875
LLPS-Hos-1756Homo sapiens91.990.01037
LLPS-Gog-1278Gorilla gorilla91.990.01038
LLPS-Pap-4355Pan paniscus91.810.01035
LLPS-Rhb-0788Rhinopithecus bieti91.810.01020
LLPS-Pat-0093Pan troglodytes91.640.01034
LLPS-Cea-4739Cercocebus atys91.640.01034
LLPS-Paa-2046Papio anubis91.460.01031
LLPS-Maf-4585Macaca fascicularis91.460.01031
LLPS-Ict-3889Ictidomys tridecemlineatus90.80.01014
LLPS-Caj-4121Callithrix jacchus90.770.01027
LLPS-Sus-1016Sus scrofa90.750.0 902
LLPS-Loa-2052Loxodonta africana90.420.01028
LLPS-Cap-4512Cavia porcellus90.390.0 967
LLPS-Bot-3828Bos taurus89.380.0 915
LLPS-Mea-0647Mesocricetus auratus89.350.01009
LLPS-Orc-0670Oryctolagus cuniculus89.180.01018
LLPS-Fud-3445Fukomys damarensis89.090.0 951
LLPS-Myl-0321Myotis lucifugus88.870.01016
LLPS-Mum-3304Mus musculus88.850.01002
LLPS-Ran-3620Rattus norvegicus88.680.01000
LLPS-Otg-3549Otolemur garnettii88.50.0 999
LLPS-Eqc-4453Equus caballus88.150.01003
LLPS-Tut-2353Tursiops truncatus87.730.01018
LLPS-Dio-3688Dipodomys ordii87.720.0 982
LLPS-Fec-0144Felis catus87.540.0 989
LLPS-Aon-4502Aotus nancymaae86.910.0 966
LLPS-Sah-0626Sarcophilus harrisii86.480.0 960
LLPS-Ova-0929Ovis aries84.650.0 979
LLPS-Mod-3101Monodelphis domestica82.650.0 885
LLPS-Mal-2030Mandrillus leucophaeus81.460.0 875
LLPS-Nol-3932Nomascus leucogenys79.810.0 825
LLPS-Lac-4092Latimeria chalumnae75.760.0 781
LLPS-Xet-0727Xenopus tropicalis75.090.0 778
LLPS-Ora-0940Ornithorhynchus anatinus75.08e-121 365
LLPS-Leo-1579Lepisosteus oculatus71.810.0 773
LLPS-Tag-0182Taeniopygia guttata70.860.0 735
LLPS-Anp-1067Anas platyrhynchos70.670.0 732
LLPS-Pes-2692Pelodiscus sinensis70.380.0 730
LLPS-Icp-0476Ictalurus punctatus69.660.0 743
LLPS-Anc-0061Anolis carolinensis69.620.0 739
LLPS-Cas-2320Carlito syrichta69.490.0 737
LLPS-Asm-1232Astyanax mexicanus69.410.0 726
LLPS-Gaga-2684Gallus gallus69.330.0 744
LLPS-Scf-1515Scleropages formosus69.20.0 754
LLPS-Tar-0743Takifugu rubripes69.190.0 750
LLPS-Meg-0347Meleagris gallopavo69.140.0 743
LLPS-Xim-0138Xiphophorus maculatus68.940.0 749
LLPS-Orl-1831Oryzias latipes68.820.0 751
LLPS-Pof-1429Poecilia formosa68.750.0 750
LLPS-Urm-1530Ursus maritimus68.510.0 709
LLPS-Orn-2744Oreochromis niloticus68.420.0 751
LLPS-Fia-2080Ficedula albicollis68.40.0 751
LLPS-Gaa-3189Gasterosteus aculeatus68.190.0 745
LLPS-Scm-0244Scophthalmus maximus68.130.0 741
LLPS-Dar-1153Danio rerio67.810.0 740
LLPS-Ten-3004Tetraodon nigroviridis67.670.0 740
LLPS-Cii-0258Ciona intestinalis64.370.0 675
LLPS-Cis-1169Ciona savignyi63.150.0 674
LLPS-Drm-0086Drosophila melanogaster59.220.0 592
LLPS-Cae-0858Caenorhabditis elegans55.720.0 575
LLPS-Crn-1265Cryptococcus neoformans54.794e-172 508
LLPS-Put-0765Puccinia triticina54.781e-123 376
LLPS-Asfu-0299Aspergillus fumigatus53.772e-171 505
LLPS-Scc-0718Schizosaccharomyces cryophilus53.667e-168 495
LLPS-Scj-0721Schizosaccharomyces japonicus53.278e-169 497
LLPS-Ast-0020Aspergillus terreus53.163e-171 504
LLPS-Nef-0570Neosartorya fischeri52.953e-172 507
LLPS-Asc-0750Aspergillus clavatus52.752e-170 502
LLPS-Miv-1002Microbotryum violaceum52.741e-166 493
LLPS-Scp-1444Schizosaccharomyces pombe52.49e-167 492
LLPS-Asn-0064Aspergillus nidulans52.348e-169 498
LLPS-Aso-1442Aspergillus oryzae52.143e-168 496
LLPS-Asf-1349Aspergillus flavus52.143e-168 496
LLPS-Asni-0078Aspergillus niger52.148e-169 498
LLPS-Spr-0346Sporisorium reilianum52.032e-165 489
LLPS-Pug-1290Puccinia graminis51.721e-162 483
LLPS-Usm-0900Ustilago maydis51.635e-166 491
LLPS-Abg-0614Absidia glauca51.413e-164 486
LLPS-Dos-0593Dothistroma septosporum51.112e-166 492
LLPS-Pytr-0392Pyrenophora triticirepentis50.982e-166 491
LLPS-Pyt-0104Pyrenophora teres50.985e-166 491
LLPS-Trv-0874Trichoderma virens50.922e-158 471
LLPS-Yal-1059Yarrowia lipolytica50.891e-169 499
LLPS-Scs-0235Sclerotinia sclerotiorum50.815e-154 460
LLPS-Mel-0328Melampsora laricipopulina50.815e-160 475
LLPS-Phn-1023Phaeosphaeria nodorum50.791e-168 498
LLPS-Gas-0532Galdieria sulphuraria50.71e-140 425
LLPS-Zyt-0601Zymoseptoria tritici50.61e-162 482
LLPS-Lem-1431Leptosphaeria maculans50.593e-164 487
LLPS-Blg-0746Blumeria graminis50.411e-151 454
LLPS-Trr-0453Trichoderma reesei50.314e-156 466
LLPS-Asg-1230Ashbya gossypii50.16e-157 466
LLPS-Fus-0477Fusarium solani49.694e-153 458
LLPS-Kop-1219Komagataella pastoris49.63e-161 478
LLPS-Sac-0389Saccharomyces cerevisiae49.491e-154 461
LLPS-Mao-1105Magnaporthe oryzae49.293e-152 456
LLPS-Ved-0369Verticillium dahliae49.193e-150 450
LLPS-Cogr-1124Colletotrichum graminicola49.084e-152 455
LLPS-Coo-1281Colletotrichum orbiculare49.089e-152 454
LLPS-Tum-0618Tuber melanosporum48.942e-158 470
LLPS-Fuo-0350Fusarium oxysporum48.889e-153 457
LLPS-Fuv-0200Fusarium verticillioides48.881e-152 456
LLPS-Gag-1300Gaeumannomyces graminis48.829e-154 459
LLPS-Beb-0422Beauveria bassiana48.787e-159 473
LLPS-Map-0615Magnaporthe poae48.624e-153 458
LLPS-Chc-0234Chondrus crispus48.471e-134 409
LLPS-Nec-0013Neurospora crassa47.133e-151 453
LLPS-Chr-0577Chlamydomonas reinhardtii46.273e-128 393
LLPS-Cym-0263Cyanidioschyzon merolae45.957e-130 397
LLPS-Cog-0124Colletotrichum gloeosporioides45.628e-135 410
LLPS-Hea-1225Helianthus annuus45.447e-125 384
LLPS-Orbr-0544Oryza brachyantha45.239e-123 379
LLPS-Brn-0568Brassica napus45.223e-122 377
LLPS-Orm-1168Oryza meridionalis44.819e-123 379
LLPS-Org-0923Oryza glaberrima44.819e-123 379
LLPS-Ors-0201Oryza sativa44.819e-123 379
LLPS-Orgl-2045Oryza glumaepatula44.819e-123 379
LLPS-Cus-1872Cucumis sativus44.814e-123 380
LLPS-Ori-0265Oryza indica44.819e-123 379
LLPS-Orb-0574Oryza barthii44.819e-123 379
LLPS-Orni-1501Oryza nivara44.819e-123 379
LLPS-Orr-0940Oryza rufipogon44.632e-122 379
LLPS-Arl-1133Arabidopsis lyrata44.424e-122 377
LLPS-Brr-2113Brassica rapa44.46e-119 369
LLPS-Zem-1513Zea mays44.211e-121 379
LLPS-Art-2542Arabidopsis thaliana44.212e-121 376
LLPS-Tra-2322Triticum aestivum44.212e-123 381
LLPS-Brd-0367Brachypodium distachyon44.211e-121 376
LLPS-Met-0327Medicago truncatula44.214e-124 382
LLPS-Dac-1406Daucus carota44.213e-125 385
LLPS-Orp-1430Oryza punctata44.041e-123 381
LLPS-Bro-2128Brassica oleracea44.016e-120 372
LLPS-Amt-0957Amborella trichopoda44.012e-121 375
LLPS-Prp-0157Prunus persica43.989e-122 376
LLPS-Nia-1028Nicotiana attenuata43.982e-121 376
LLPS-Sob-0214Sorghum bicolor43.862e-122 378
LLPS-Sei-2029Setaria italica43.83e-121 375
LLPS-Thc-0692Theobroma cacao43.82e-122 378
LLPS-Sot-1500Solanum tuberosum43.783e-119 370
LLPS-Lep-1500Leersia perrieri43.669e-121 374
LLPS-Coc-1481Corchorus capsularis43.62e-123 380
LLPS-Viv-1106Vitis vinifera43.63e-117 365
LLPS-Sol-0446Solanum lycopersicum43.575e-119 369
LLPS-Tru-1578Triticum urartu43.457e-117 363
LLPS-Pot-1588Populus trichocarpa43.392e-124 384
LLPS-Gor-0926Gossypium raimondii43.391e-119 371
LLPS-Phv-0505Phaseolus vulgaris43.181e-120 374
LLPS-Glm-2661Glycine max43.181e-119 371
LLPS-Mua-1633Musa acuminata43.141e-120 373
LLPS-Via-1067Vigna angularis42.981e-120 374
LLPS-Vir-1424Vigna radiata42.986e-121 374
LLPS-Sem-0593Selaginella moellendorffii42.662e-121 375
LLPS-Php-2443Physcomitrella patens42.62e-119 371
LLPS-Mae-2279Manihot esculenta41.433e-118 367