• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Abg-1945
ABSGL_04618.1 scaffold 5475

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: PAN2-PAN3 deadenylation complex catalytic subunit PAN2; PAB1P-dependent poly(A)-specific ribonuclease; Poly(A)-nuclease deadenylation complex subunit 2; PAN deadenylation complex subunit 2
Gene Name: ABSGL_04618.1 scaffold 5475, PAN2
Ensembl Gene: SAL99047
Ensembl Protein: SAL99047
Organism: Absidia glauca
Taxa ID: 4829
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION


Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblSAL99047SAL99047
UniProtA0A168MRG0, A0A168MRG0_ABSGL
GeneBankLT552383SAL99047.1

▼ SEQUENCE


Protein Sequence (FASTA)
1     MESTWTEVQQ  VCDTNPNKVS  PVSALCWDPY  HELLWAGNDT  GRVCSYYGKG  LQRYTSFKAH  60
61    ADQQIRQIRV  TERGVISLSP  KSVQMRDRQG  LVRWNISTEH  MKDLHCMTTT  SLTNGDLLVA  120
121   GQQNDMLMVS  AARGTVTKSI  PGASNIVVMR  NLPRAICCGS  MLGDVTIRDT  RTMKVEQRVQ  180
181   AHTATLSDLD  VSGNLLLTCG  FSQRQGSLIM  DPLVKVYDIR  MAIRSLAPIP  FPSGPMFLKM  240
241   HPTLSSTCLV  GSQTGQFQMC  DVSSLAMGSF  APTSHFYQVQ  SSSYITAMDI  SSSGQTLVFG  300
301   DGNSFIHQYA  DRDNYVMNPY  SIPVTTPDTA  PPPNVLVNND  TPLSAVGMPF  YTEPLLSAWT  360
361   NGSVYDVGHP  APQIDDDILK  SIKTIDFVGY  APNPGTIHRN  QIPRRKKQPH  KKDIPKFRSE  420
421   QERELLSASV  LLDESGELMH  SGRRSSSVGD  VLMDLHGIVM  PNHYRHVEIQ  YSKFGVDDFD  480
481   FGYYNRTLYG  GLETNIRNSY  CNSLLQVLYF  TLPLRQIAKC  HICTSCDKEN  CLMCELGFLF  540
541   RMLEDSNGQN  CQATNFLKAF  STIPQADALG  LFEPESPTRN  ISYSMMIQNF  VRFILEQLHQ  600
601   EANTPTSNPV  ILTTYKSPPK  TTDKEEETDA  DTPATIPSPM  QQLFGLQTLT  QSKCSVCDNE  660
661   ASRITYPFAV  DLLYPKKQRK  RTFASLLKTS  MYRENQTKAW  CATCQKYQST  TTKKIIQGLP  720
721   GVLVINSGAY  SSEEASIWRQ  NGPSSPKTRT  ESPNQENEGP  SEVASWLPER  FGILINGPEL  780
781   TIKLLPLDKE  IPPEFVGPPE  TCAIYELSST  ILQVQAEEEA  AHLVAQVKIP  DTERMTYTSA  840
841   TGLEEEEKAK  SPWYVFNDFL  VKRIRAEETT  SFKGLWKTPA  VIQYTRVDID  SLLDLDTLSS  900
901   EVDYSLLFKE  MSIAKNTPEK  SSYDILTKDE  MPTPGTLIAI  DSEFVALRQE  ETEIRSDGTK  960
961   SLIRPSTLSL  ARLSVTRGED  GDKEGLPFID  DYIVTSEPVV  DYLTEFSGIE  ADDLNPMTSH  1020
1021  RTLVPLKVAY  KKIRLLVDLG  CVFIGHGLKK  DFRIINILVP  PDQIIDTVDI  YHIRNRHRKI  1080
1081  SLRFLAWHLL  GQEIQSEGHD  SIVDAKTALV  LYKKYLEYRE  KGTFGQVLEG  VYAAGHKSNW  1140
1141  LKAPKDTPSV  PSTPKVEQSH  SYFTPGWAL  1169

▼ KEYWORD


ID
Family
Complete proteome
Cytoplasm
Exonuclease
Hydrolase
Metal-binding
mRNA processing
Nuclease
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
PAN complex
Molecular Function
Metal ion binding
Molecular Function
Nucleic acid binding
Molecular Function
Poly(A)-specific ribonuclease activity
Biological Process
MRNA processing
Biological Process
Nuclear-transcribed mRNA poly(A) tail shortening

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cii-1716Ciona intestinalis54.026e-67 231
LLPS-Osl-0937Ostreococcus lucimarinus51.613e-63 220
LLPS-Scs-1066Sclerotinia sclerotiorum47.98e-60 226
LLPS-Leo-0233Lepisosteus oculatus43.945e-78 285
LLPS-Poa-3876Pongo abelii43.75e-80 289
LLPS-Fuv-0770Fusarium verticillioides41.214e-91 306
LLPS-Put-1274Puccinia triticina40.835e-35 149
LLPS-Fuo-1045Fusarium oxysporum40.459e-89 299
LLPS-Miv-1580Microbotryum violaceum40.050.0 803
LLPS-Pug-0117Puccinia graminis39.556e-1480.9
LLPS-Crn-1254Cryptococcus neoformans39.420.0 728
LLPS-Gas-1286Galdieria sulphuraria39.216e-55 213
LLPS-Tum-1577Tuber melanosporum38.130.0 731
LLPS-Trr-0872Trichoderma reesei37.970.0 747
LLPS-Cog-1051Colletotrichum gloeosporioides37.740.0 748
LLPS-Pof-1413Poecilia formosa37.620.0 699
LLPS-Gaga-3631Gallus gallus37.520.0 699
LLPS-Spr-0613Sporisorium reilianum37.51e-157 514
LLPS-Ved-1409Verticillium dahliae37.390.0 691
LLPS-Fia-1463Ficedula albicollis37.360.0 702
LLPS-Ten-2327Tetraodon nigroviridis37.310.0 683
LLPS-Meg-0076Meleagris gallopavo37.230.0 677
LLPS-Cogr-0246Colletotrichum graminicola37.210.0 750
LLPS-Nol-0528Nomascus leucogenys37.192e-125 421
LLPS-Xim-3299Xiphophorus maculatus37.10.0 697
LLPS-Scf-3812Scleropages formosus37.080.0 684
LLPS-Coo-0952Colletotrichum orbiculare37.010.0 731
LLPS-Beb-0623Beauveria bassiana36.980.0 760
LLPS-Scp-1489Schizosaccharomyces pombe36.920.0 729
LLPS-Dar-3387Danio rerio36.914e-1272.8
LLPS-Scm-3441Scophthalmus maximus36.890.0 664
LLPS-Pyt-1307Pyrenophora teres36.870.0 743
LLPS-Orbr-1756Oryza brachyantha36.817e-1170.5
LLPS-Orn-3221Oreochromis niloticus36.80.0 682
LLPS-Fus-0330Fusarium solani36.87e-128 425
LLPS-Asn-1423Aspergillus nidulans36.780.0 728
LLPS-Orl-2531Oryzias latipes36.780.0 671
LLPS-Gaa-3809Gasterosteus aculeatus36.740.0 670
LLPS-Map-1411Magnaporthe poae36.730.0 725
LLPS-Scj-1391Schizosaccharomyces japonicus36.690.0 724
LLPS-Lem-0235Leptosphaeria maculans36.680.0 732
LLPS-Icp-3899Ictalurus punctatus36.670.0 674
LLPS-Pytr-1632Pyrenophora triticirepentis36.620.0 734
LLPS-Anc-0658Anolis carolinensis36.570.0 708
LLPS-Asm-2618Astyanax mexicanus36.460.0 669
LLPS-Mea-2826Mesocricetus auratus36.430.0 692
LLPS-Cas-3899Carlito syrichta36.40.0 686
LLPS-Nef-1244Neosartorya fischeri36.390.0 723
LLPS-Orc-2411Oryctolagus cuniculus36.390.0 685
LLPS-Asfu-1272Aspergillus fumigatus36.390.0 712
LLPS-Ict-3881Ictidomys tridecemlineatus36.371e-177 560
LLPS-Sah-1866Sarcophilus harrisii36.360.0 655
LLPS-Blg-1525Blumeria graminis36.360.0 724
LLPS-Anp-2788Anas platyrhynchos36.360.0 639
LLPS-Mum-3052Mus musculus36.330.0 690
LLPS-Ran-1096Rattus norvegicus36.330.0 689
LLPS-Pes-1224Pelodiscus sinensis36.30.0 665
LLPS-Pat-0899Pan troglodytes36.30.0 686
LLPS-Pap-3376Pan paniscus36.30.0 686
LLPS-Tar-3013Takifugu rubripes36.250.0 680
LLPS-Loa-4165Loxodonta africana36.250.0 665
LLPS-Fud-3710Fukomys damarensis36.240.0 677
LLPS-Ast-1510Aspergillus terreus36.210.0 702
LLPS-Gog-2706Gorilla gorilla36.180.0 686
LLPS-Aim-3621Ailuropoda melanoleuca36.180.0 682
LLPS-Asni-0745Aspergillus niger36.170.0 696
LLPS-Maf-3059Macaca fascicularis36.140.0 682
LLPS-Paa-1694Papio anubis36.140.0 665
LLPS-Mam-2857Macaca mulatta36.140.0 682
LLPS-Caf-4011Canis familiaris36.140.0 692
LLPS-Trv-1166Trichoderma virens36.137e-110 376
LLPS-Fec-3523Felis catus36.10.0 692
LLPS-Hos-0408Homo sapiens36.10.0 684
LLPS-Asc-1184Aspergillus clavatus36.090.0 730
LLPS-Aon-4696Aotus nancymaae36.050.0 683
LLPS-Sus-3491Sus scrofa36.050.0 681
LLPS-Mup-0732Mustela putorius furo36.050.0 684
LLPS-Bot-0392Bos taurus36.050.0 681
LLPS-Rhb-3863Rhinopithecus bieti36.050.0 682
LLPS-Usm-1493Ustilago maydis36.056e-155 507
LLPS-Eqc-1050Equus caballus36.050.0 682
LLPS-Mal-4486Mandrillus leucophaeus36.040.0 687
LLPS-Otg-3709Otolemur garnettii36.030.0 696
LLPS-Caj-4811Callithrix jacchus36.020.0 683
LLPS-Gag-1478Gaeumannomyces graminis36.010.0 710
LLPS-Cea-0502Cercocebus atys35.970.0 683
LLPS-Man-4247Macaca nemestrina35.970.0 681
LLPS-Chs-4486Chlorocebus sabaeus35.930.0 683
LLPS-Ova-3821Ovis aries35.930.0 678
LLPS-Myl-1121Myotis lucifugus35.890.0 688
LLPS-Vir-1802Vigna radiata35.866e-1067.4
LLPS-Via-2046Vigna angularis35.867e-1067.8
LLPS-Urm-2045Ursus maritimus35.810.0 682
LLPS-Xet-2874Xenopus tropicalis35.810.0 700
LLPS-Cap-2317Cavia porcellus35.70.0 682
LLPS-Mel-0943Melampsora laricipopulina35.570.0 667
LLPS-Asf-0192Aspergillus flavus35.560.0 694
LLPS-Aso-0823Aspergillus oryzae35.480.0 692
LLPS-Ora-2823Ornithorhynchus anatinus35.441e-169 535
LLPS-Chr-1395Chlamydomonas reinhardtii35.46e-37 156
LLPS-Phn-1341Phaeosphaeria nodorum35.320.0 646
LLPS-Scc-1282Schizosaccharomyces cryophilus35.030.0 694
LLPS-Mao-0272Magnaporthe oryzae34.660.0 623
LLPS-Zyt-1485Zymoseptoria tritici34.630.0 650
LLPS-Mod-0176Monodelphis domestica34.422e-1068.2
LLPS-Tut-0876Tursiops truncatus34.383e-1479.0
LLPS-Sot-0079Solanum tuberosum34.094e-1168.9
LLPS-Met-0278Medicago truncatula34.015e-1274.3
LLPS-Dos-1491Dothistroma septosporum33.840.0 641
LLPS-Nec-1021Neurospora crassa33.780.0 634
LLPS-Drm-1684Drosophila melanogaster33.410.0 613
LLPS-Cym-0703Cyanidioschyzon merolae33.331e-1069.7
LLPS-Lac-2979Latimeria chalumnae33.330.0 584
LLPS-Cis-1937Ciona savignyi32.489e-163 521
LLPS-Tag-3385Taeniopygia guttata32.452e-1273.2
LLPS-Yal-0978Yarrowia lipolytica32.021e-139 452
LLPS-Dio-0720Dipodomys ordii31.753e-1067.0
LLPS-Php-0557Physcomitrella patens31.671e-180 570
LLPS-Brn-2912Brassica napus31.469e-1170.5
LLPS-Tra-2673Triticum aestivum31.391e-0964.3
LLPS-Gor-1403Gossypium raimondii31.162e-1067.4
LLPS-Cae-1255Caenorhabditis elegans30.567e-1065.1
LLPS-Brr-1401Brassica rapa30.531e-1170.9
LLPS-Arl-1912Arabidopsis lyrata30.412e-1273.2
LLPS-Coc-0572Corchorus capsularis30.273e-1169.3
LLPS-Kop-1504Komagataella pastoris30.228e-164 523
LLPS-Art-0041Arabidopsis thaliana30.164e-1168.9
LLPS-Asg-0865Ashbya gossypii29.631e-140 462
LLPS-Sob-1251Sorghum bicolor29.632e-1273.6
LLPS-Sol-1375Solanum lycopersicum29.591e-1170.5
LLPS-Glm-2592Glycine max29.472e-0963.5
LLPS-Pot-2388Populus trichocarpa29.323e-1169.3
LLPS-Sei-1087Setaria italica29.15e-1272.0
LLPS-Mae-1283Manihot esculenta28.81e-1067.4
LLPS-Phv-0655Phaseolus vulgaris28.572e-0963.5
LLPS-Sac-1363Saccharomyces cerevisiae28.448e-127 424
LLPS-Cus-0069Cucumis sativus28.262e-0963.9
LLPS-Chc-0820Chondrus crispus28.212e-119 406
LLPS-Hea-1761Helianthus annuus28.192e-0963.5
LLPS-Prp-0672Prunus persica28.116e-1065.1
LLPS-Zem-1140Zea mays27.892e-1067.0
LLPS-Mua-0966Musa acuminata27.525e-1168.6
LLPS-Orni-1155Oryza nivara27.172e-0964.7
LLPS-Lep-1088Leersia perrieri27.173e-0963.9
LLPS-Orp-0700Oryza punctata27.172e-0964.7
LLPS-Orm-1696Oryza meridionalis27.173e-0963.9
LLPS-Viv-0824Vitis vinifera26.671e-1170.9