※ siRNA body introduction siRNA bodies are RNA granules associated with the synthesis of tasiRNA and the amplification of the RNA silencing signal. Many plant viruses interfere with siRNA body functions in order to suppress their contribution to siRNA production (1). Upon stress-induced translational repression, siRNA bodies become positive for stress-granules markers, suggesting that these bodies may accumulate stalled mRNAs (2).
Reference
1. Mäkinen, K., Lõhmus, A., Pollari, M. (2017) Plant RNA Regulatory Network and RNA Granules in Virus Infection. Front Plant Sci, 11(8):2093. PMID: 29312371
1. Jouannet, V., Moreno, AB., Elmayan, T., Vaucheret, H., Crespi, MD., Maizel, A. (2012) Cytoplasmic Arabidopsis AGO7 accumulates in membrane-associated siRNA bodies and is required for ta-siRNA biogenesis. EMBO J, 31(7):1704-13. PMID: 22327216
siRNA body in eukaryotes (Total number, Predicted number):
1. Mäkinen, K., Lõhmus, A., Pollari, M. (2017) Plant RNA Regulatory Network and RNA Granules in Virus Infection. Front Plant Sci, 11(8):2093. PMID: 29312371
1. Jouannet, V., Moreno, AB., Elmayan, T., Vaucheret, H., Crespi, MD., Maizel, A. (2012) Cytoplasmic Arabidopsis AGO7 accumulates in membrane-associated siRNA bodies and is required for ta-siRNA biogenesis. EMBO J, 31(7):1704-13. PMID: 22327216
siRNA body in eukaryotes (Total number, Predicted number):