※ PcG body introduction

    PcG bodies, termed polycomb bodies, are subnuclear organelles containing polycomb group proteins. They are a kind of PMLOs located in nucleus, which possess liquid-like behavior and are believed to be formed as a result of biological liquid-liquid phase transitions, where an intricate interplay between RNA and intrinsically disordered proteins (IDPs) or hybrid proteins containing ordered domains and intrinsically disordered protein regions (IDPRs) may play an important role, they are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). They correspond to local accumulations of PcG proteins, which are important epigenetic regulators that control transcription of their target genes (2). Morover, Polycomb body–associated PHC2 was found to interact with the Polycomb repressive complex, which is relevant to the function of polycomb bodies in transcription regulation (3).

Reference
1. Uversky, V. N. (2017) MappingIntrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525
2. Smigova, J., Juda, P., Krejci, J., & Raska, I. (2014) MappingStructural basis of polycomb bodies. Folia Biol (Praha), 60 Suppl 1, 13-20. PMID: 25369336
3. Fong, K. W., Li, Y., Wang, W., Ma, W., Li, K., Qi, R. Z., et al. (2013) MappingWhole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol, 203(1), 149-164. PMID: 24127217