Saccharomyces cerevisiae      Spindle apparatus


※ Spindle apparatus introduction

    The spindle is an important structure when cells divide. Phase separation promotes the concentration of molecules into the droplets, thereby promoting biochemical reactions. Some protein mixtures undergo a phase change to form droplets that concentrate actin to promote F-actin assembly in vitro. In addition, studies have shown that the phase transition of spindle regulatory protein BuGZ concentrates tubulin and promotes MT polymerizationbinds to tubulin and promotes spindle assembly (1).

Reference
1. Jiang, H., Wang, S., Huang, Y., He, X., Cui, H., Zhu, X., & Zheng, Y. (2015) Phase transition of spindle-associated protein regulate spindle apparatus assembly. Cell, 163(1), 108-122. PMID: 26388440


There are 8 genes.  Reviewed (5 or Unreviewed (3

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Sac-0377
YOR058C
P50275
ASE1
2
LLPS-Sac-0055
YBL063W
P28742
KIP1
3
LLPS-Sac-0318
YLR045C
P46675
STU2
4
LLPS-Sac-0696
YJR066W
P35169
TOR1
5
LLPS-Sac-0112
YLR212C
P53378
TUB4
6
LLPS-Sac-1236
YJL194W
P09119
CDC6
7
LLPS-Sac-0300
YJL030W
P40958
MAD2
8
LLPS-Sac-0338
YJL074C
P47037
SMC3