Caenorhabditis elegans      Spindle apparatus


※ Spindle apparatus introduction

    The spindle is an important structure when cells divide. Phase separation promotes the concentration of molecules into the droplets, thereby promoting biochemical reactions. Some protein mixtures undergo a phase change to form droplets that concentrate actin to promote F-actin assembly in vitro. In addition, studies have shown that the phase transition of spindle regulatory protein BuGZ concentrates tubulin and promotes MT polymerizationbinds to tubulin and promotes spindle assembly (1).

Reference
1. Jiang, H., Wang, S., Huang, Y., He, X., Cui, H., Zhu, X., & Zheng, Y. (2015) Phase transition of spindle-associated protein regulate spindle apparatus assembly. Cell, 163(1), 108-122. PMID: 26388440


There are 20 genes.  Reviewed (10 or Unreviewed (10

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cae-0355
WBGene00000098
G5EDL3
air-1
2
LLPS-Cae-0231
WBGene00001333
G5EBK3
erm-1
3
LLPS-Cae-2085
WBGene00001688
Q95QJ7
gpr-1
4
LLPS-Cae-2086
WBGene00001689
Q03569
gpr-2
5
LLPS-Cae-1781
WBGene00002583
Q95Q95
let-363
6
LLPS-Cae-0147
WBGene00003183
P34808
mei-1
7
LLPS-Cae-2105
WBGene00003868
Q9XVW6
ooc-3
8
LLPS-Cae-0293
WBGene00003918
Q17353
par-3
9
LLPS-Cae-2117
WBGene00004955
P91349
spd-5
10
LLPS-Cae-0079
WBGene00006994
G5EEM5
zyg-9
11
LLPS-Cae-1370
WBGene00000092
Q19955
ags-3
12
LLPS-Cae-0632
WBGene00000382
P91155
cdc-6
13
LLPS-Cae-0901
WBGene00013202
Q9XWK4
CELE_Y54E5A.7
14
LLPS-Cae-0586
WBGene00012156
Q9XXA2
ebp-2
15
LLPS-Cae-0063
WBGene00003161
Q9NGT3
mdf-2
16
LLPS-Cae-0946
WBGene00011304
Q8I113
mnk-1
17
LLPS-Cae-0638
WBGene00011994
Q22747
samp-1
18
LLPS-Cae-0472
WBGene00004873
B2FDA8
smc-3
19
LLPS-Cae-1025
WBGene00006816
Q20745
unc-84
20
LLPS-Cae-1029
WBGene00007105
Q9U3S8
znf-207