Rattus norvegicus      Sam68 nuclear body


※ Sam68 nuclear body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Sam68 nuclear bodies (SNBs) is a kind of these bodies located in Nucleus, Its component of Nucleic acids or RNPs are Chloroplast-specific mRNAs Long non-coding RNA, and it is related to mRNAs trafficking through the nucleus (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID:27838525


There are 12 genes.  Reviewed (2 or Unreviewed (10

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ran-0590
ENSRNOG00000019113.7
P61980
Hnrnpk
2
LLPS-Ran-0026
ENSRNOG00000046794.1
Q91V33
Khdrbs1
3
LLPS-Ran-0717
ENSRNOG00000002292.8
Q9JJ54
Hnrnpd
4
LLPS-Ran-2550
ENSRNOG00000020235.8
F1LQ48
Hnrnpl
5
LLPS-Ran-3025
ENSRNOG00000012284.6
Q920F3
Khdrbs2
6
LLPS-Ran-1644
ENSRNOG00000009539.7
Q9JLP1
Khdrbs3
7
LLPS-Ran-0896
ENSRNOG00000010783.6
Q5EB56
Mak16
8
LLPS-Ran-0446
ENSRNOG00000018069.4
D3ZBL3
Ngdn
9
LLPS-Ran-4167
ENSRNOG00000000866.7
Q4V898
Rbmx
10
LLPS-Ran-2546
ENSRNOG00000018067.6
O35876
Smn1
11
LLPS-Ran-2883
ENSRNOG00000013013.6
Q9JIT3
Tle3
12
LLPS-Ran-4411
ENSRNOG00000001996.7
Q9QY02
Ythdc1