Drosophila melanogaster      Sam68 nuclear body


※ Sam68 nuclear body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Sam68 nuclear bodies (SNBs) is a kind of these bodies located in Nucleus, Its component of Nucleic acids or RNPs are Chloroplast-specific mRNAs Long non-coding RNA, and it is related to mRNAs trafficking through the nucleus (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID:27838525


There are 10 genes.  Reviewed (1 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Drm-0113
FBgn0263396
Q08473
sqd
2
LLPS-Drm-2221
FBgn0034739
Q9W240
BcDNA:AT29209
3
LLPS-Drm-0422
FBgn0031736
Q9VMM7
DmelCG11030
4
LLPS-Drm-1778
FBgn0001139
P16371
gro
5
LLPS-Drm-0866
FBgn0267791
A1ZBW0
HnRNP-K
6
LLPS-Drm-1017
FBgn0022986
Q9W255
qkr58E-1
7
LLPS-Drm-2142
FBgn0030067
Q9W3B2
Rbm13
8
LLPS-Drm-1828
FBgn0003435
A0A0B4K7I2
sm
9
LLPS-Drm-0682
FBgn0036641
Q9VV74
Smn
10
LLPS-Drm-0427
FBgn0027616
Q9VZQ1
Ythdc1