Caenorhabditis elegans      Sam68 nuclear body


※ Sam68 nuclear body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Sam68 nuclear bodies (SNBs) is a kind of these bodies located in Nucleus, Its component of Nucleic acids or RNPs are Chloroplast-specific mRNAs Long non-coding RNA, and it is related to mRNAs trafficking through the nucleus (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID:27838525


There are 5 genes.  Reviewed (1 or Unreviewed (4

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cae-0321
WBGene00004887
G5EC16
smn-1
2
LLPS-Cae-1204
WBGene00015811
Q18035
C16A3.6
3
LLPS-Cae-2032
WBGene00017816
P91277
hrpk-1
4
LLPS-Cae-1128
WBGene00016624
Q95QR5
hrpl-1
5
LLPS-Cae-0443
WBGene00003059
Q8IG68
lpd-2