※ PcG body introduction

    PcG bodies, termed polycomb bodies, are subnuclear organelles containing polycomb group proteins. They are a kind of PMLOs located in nucleus, which possess liquid-like behavior and are believed to be formed as a result of biological liquid-liquid phase transitions, where an intricate interplay between RNA and intrinsically disordered proteins (IDPs) or hybrid proteins containing ordered domains and intrinsically disordered protein regions (IDPRs) may play an important role, they are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). They correspond to local accumulations of PcG proteins, which are important epigenetic regulators that control transcription of their target genes (2). Morover, Polycomb body–associated PHC2 was found to interact with the Polycomb repressive complex, which is relevant to the function of polycomb bodies in transcription regulation (3).

Reference
1. Uversky, V. N. (2017) MappingIntrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525
2. Smigova, J., Juda, P., Krejci, J., & Raska, I. (2014) MappingStructural basis of polycomb bodies. Folia Biol (Praha), 60 Suppl 1, 13-20. PMID: 25369336
3. Fong, K. W., Li, Y., Wang, W., Ma, W., Li, K., Qi, R. Z., et al. (2013) MappingWhole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol, 203(1), 149-164. PMID: 24127217

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No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Tag-0098	ENSTGUG00000010973.1	H0ZL33
2		LLPS-Tag-0151	ENSTGUG00000014522.1	H0ZW99
3		LLPS-Tag-0611	ENSTGUG00000005964.1	H0Z6F0
4		LLPS-Tag-2375	ENSTGUG00000001203.1	H0YSI3
5		LLPS-Tag-1457	ENSTGUG00000012348.1	H0ZQ28	AEBP2
6		LLPS-Tag-0037	ENSTGUG00000012652.1	H0ZQY8	AGO2
7		LLPS-Tag-1442	ENSTGUG00000006264.1	H0Z7A1	BAP1
8		LLPS-Tag-3083	ENSTGUG00000003161.1	H0YY78	CBX2
9		LLPS-Tag-0300	ENSTGUG00000003149.1	H0YY69	CBX4
10		LLPS-Tag-1484	ENSTGUG00000003176.1	H0YYA8	CRAMP1
11		LLPS-Tag-1169	ENSTGUG00000005603.1	H0Z5D2	CTCF
12		LLPS-Tag-2094	ENSTGUG00000012982.1	H0ZRX6	EED
13		LLPS-Tag-0511	ENSTGUG00000001770.1	H0YU73	EZH2
14		LLPS-Tag-3494	ENSTGUG00000003430.1	H0YZ00	HOXB5
15		LLPS-Tag-1018	ENSTGUG00000006054.1	H0Z6P8	JARID2
16		LLPS-Tag-1341	ENSTGUG00000006944.1	H0Z9D1	OGT
17		LLPS-Tag-0150	ENSTGUG00000004036.1	H0Z0U5	PCNA
18		LLPS-Tag-3011	ENSTGUG00000014064.1	H0ZV10	PHC2
19		LLPS-Tag-2010	ENSTGUG00000001362.1	H0YT02	RBBP4
20		LLPS-Tag-1478	ENSTGUG00000005994.1	H0Z6H7	RNF111
21		LLPS-Tag-1055	ENSTGUG00000003764.1	H0YZZ3	RNF2
22		LLPS-Tag-1219	ENSTGUG00000004968.1	H0Z3J3	SUZ12
23		LLPS-Tag-2667	ENSTGUG00000005657.1	H0Z5J4	WAPL
24		LLPS-Tag-1068	ENSTGUG00000012753.1	H0ZR87	YY1