※ Nuclear speckle introduction

    Nuclear speckles or splicing speckles, also known as interchromatin granule clusters, are membrane-less nuclear organelles enriched in pre-mRNA splicing and transcription factors and play important roles in RNA metabolism, such as transcription, pre-mRNA splicing, 3′-end mRNA processing, and execution of mRNA nuclear export (1; 2). They are dynamic subnuclear structures, and their size, shape, and number can vary accompanied with RNA regulation, nuclear speckles disperse in high activity of mRNA processing when transcription or pre-mRNA splicing is inhibited, GSK-3β can regulate assembly of nuclear speckles (2). Because many naturally intronless mRNAs, including eight exogenously expressed and four endogenous ones, are proved to be associate with NSs, So Nuclear speckles (NSs) are thought to serve as splicing factor storage sites (3).

Reference
1. Lee, K. H., Zhang, P., Kim, H. J., Mitrea, D. M., Sarkar, M., Freibaum, B. D., et al. (2016) C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell, 167(3), 774-788 e717. PMID: 27768896
2. Wang, K., Wang, L., Wang, J., Chen, S., Shi, M., & Cheng, H. (2018) Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol, 217(11), 3912-3929. PMID: 30194269
3. An, Y., Zou, Y., Cao, Y., Yao, M., Ma, N., Wu, Y., et al. (2019) The nuclear GSK-3beta regulated post-transcriptional processing of mRNA through phosphorylation of SC35. Mol Cell Biochem, 451(1-2), 55-67. PMID: 30030778

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No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Tag-0323	ENSTGUG00000005007.1	H0Z3S0
2		LLPS-Tag-0534	ENSTGUG00000005216.1	H0Z491
3		LLPS-Tag-0769	ENSTGUG00000006726.1	H0Z8N4
4		LLPS-Tag-1463	ENSTGUG00000012978.1	H0ZRX1
5		LLPS-Tag-1621	ENSTGUG00000001260.1	H0YSP4
6		LLPS-Tag-1793	ENSTGUG00000009593.1	H0ZH32
7		LLPS-Tag-2162	ENSTGUG00000001178.1	H0YSG1
8		LLPS-Tag-2237	ENSTGUG00000013036.1	H0ZS32
9		LLPS-Tag-2311	ENSTGUG00000016203.1	H1A0W1
10		LLPS-Tag-2818	ENSTGUG00000016087.1	H1A0J4
11		LLPS-Tag-2913	ENSTGUG00000014475.1	H0ZWA3
12		LLPS-Tag-3227	ENSTGUG00000005364.1	H0Z4L8
13		LLPS-Tag-3405	ENSTGUG00000002758.1	H0YX24
14		LLPS-Tag-0037	ENSTGUG00000012652.1	H0ZQY8	AGO2
15		LLPS-Tag-3556	ENSTGUG00000010729.1	H0ZKD5	AKAP17A
16		LLPS-Tag-3542	ENSTGUG00000003513.1	H0YZ89	ALYREF
17		LLPS-Tag-0046	ENSTGUG00000006030.1	H0Z6L8	ANXA10
18		LLPS-Tag-1436	ENSTGUG00000005370.1	H0Z4R0	ANXA2
19		LLPS-Tag-2769	ENSTGUG00000005510.1	H0Z518	ARL6IP4
20		LLPS-Tag-0063	ENSTGUG00000008533.1	H0ZE28	ATR
21		LLPS-Tag-0784	ENSTGUG00000001012.1	B5G466	BCAS2
22		LLPS-Tag-1697	ENSTGUG00000004486.1	H0Z236	C9orf78
23		LLPS-Tag-0086	ENSTGUG00000002300.1	H0YVQ2	CASC3
24		LLPS-Tag-3261	ENSTGUG00000011231.1	H0ZLV7	CCNL1
25		LLPS-Tag-0145	ENSTGUG00000013251.1	H0ZSP9	CDC5L
26		LLPS-Tag-2116	ENSTGUG00000005332.1	H0Z4J5	CDK1
27		LLPS-Tag-0161	ENSTGUG00000014190.1	H0ZVE4	CDK7
28		LLPS-Tag-0513	ENSTGUG00000003597.1	H0YZG4	CDK9
29		LLPS-Tag-2044	ENSTGUG00000007769.1	H0ZBP3	CDKL5
30		LLPS-Tag-0620	ENSTGUG00000016576.1	H1A1Z7	CLK2
31		LLPS-Tag-2454	ENSTGUG00000017417.1	H1A481	COP1
32		LLPS-Tag-2553	ENSTGUG00000000243.1	H0YPQ2	CSNK1A1
33		LLPS-Tag-1862	ENSTGUG00000006202.1	H0Z750	CTNNBL1
34		LLPS-Tag-2544	ENSTGUG00000015500.1	H0ZYY4	DGCR8
35		LLPS-Tag-0735	ENSTGUG00000006661.1	H0Z8F8	DNAJC17
36		LLPS-Tag-3383	ENSTGUG00000001091.1	H0YS59	DYRK3
37		LLPS-Tag-3653	ENSTGUG00000004206.1	H0Z1B5	EGF
38		LLPS-Tag-1582	ENSTGUG00000011445.1	H0ZMH1	ERH
39		LLPS-Tag-2742	ENSTGUG00000012811.1	H0ZRE8	FAM76B
40		LLPS-Tag-3654	ENSTGUG00000012789.1	H0ZRC5	FAM83H
41		LLPS-Tag-1867	ENSTGUG00000006733.1	H0Z8P4	FANCD2
42		LLPS-Tag-1112	ENSTGUG00000008198.1	H0ZD41	FANCI
43		LLPS-Tag-0947	ENSTGUG00000007676.1	H0ZBD9	FBXL18
44		LLPS-Tag-2467	ENSTGUG00000004881.1	H0Z3I3	FGFR1
45		LLPS-Tag-3153	ENSTGUG00000009645.1	H0ZH78	FYTTD1
46		LLPS-Tag-1000	ENSTGUG00000001834.1	H0YUC7	GLI3
47		LLPS-Tag-0003	ENSTGUG00000013380.1	H0ZT29	GSK3B
48		LLPS-Tag-2229	ENSTGUG00000011378.1	H0ZMC4	HIPK2
49		LLPS-Tag-0517	ENSTGUG00000002869.1	H0YXD2	HNRNPA2B1
50		LLPS-Tag-0931	ENSTGUG00000003138.1	H0YY68	HNRNPK
51		LLPS-Tag-1356	ENSTGUG00000011712.1	H0ZNA4	HSPH1
52		LLPS-Tag-0014	ENSTGUG00000013676.1	H0ZU10	ILF3
53		LLPS-Tag-1916	ENSTGUG00000003698.1	H0YZT6	IVNS1ABP
54		LLPS-Tag-1745	ENSTGUG00000004534.1	H0Z2A4	KPNA2
55		LLPS-Tag-3285	ENSTGUG00000004254.1	H0Z1E8	LUC7L
56		LLPS-Tag-0062	ENSTGUG00000007048.1	H0Z9M5	NONO
57		LLPS-Tag-3597	ENSTGUG00000006486.1	H0Z7X3	NSRP1
58		LLPS-Tag-1677	ENSTGUG00000008637.1	H0ZE89	OGG1
59		LLPS-Tag-2477	ENSTGUG00000011360.1	H0ZM82	P2RY12
60		LLPS-Tag-2296	ENSTGUG00000012046.1	H0ZP82	PNN
61		LLPS-Tag-3067	ENSTGUG00000007875.1	H0ZC45	PPIG
62		LLPS-Tag-0312	ENSTGUG00000006319.1	H0Z7F9	PRPF19
63		LLPS-Tag-0574	ENSTGUG00000005648.1	H0Z5L6	PRPF8
64		LLPS-Tag-0946	ENSTGUG00000011295.1	H0ZM27	PSPC1
65		LLPS-Tag-0649	ENSTGUG00000000641.1	H0YQV3	PTBP1
66		LLPS-Tag-0209	ENSTGUG00000002013.1	H0YUW1	RBM17
67		LLPS-Tag-1151	ENSTGUG00000005239.1	H0Z486	RBMX2
68		LLPS-Tag-0522	ENSTGUG00000003237.1	H0YYF9	RNPS1
69		LLPS-Tag-0315	ENSTGUG00000016126.1	H1A0Q8	SARNP
70		LLPS-Tag-2585	ENSTGUG00000010547.1	H0ZJW6	SF3A1
71		LLPS-Tag-1403	ENSTGUG00000000305.1	H0YPW4	SF3A2
72		LLPS-Tag-1427	ENSTGUG00000001466.1	H0YTB2	SF3A3
73		LLPS-Tag-0441	ENSTGUG00000010553.1	H0ZJX4	SF3B1
74		LLPS-Tag-1317	ENSTGUG00000001722.1	H0YU18	SFPQ
75		LLPS-Tag-1412	ENSTGUG00000008957.1	H0ZF70	SNRPA1
76		LLPS-Tag-1794	ENSTGUG00000010284.1	H0ZJ53	SRSF11
77		LLPS-Tag-0429	ENSTGUG00000007799.1	H0ZBS2	SRSF2
78		LLPS-Tag-1142	ENSTGUG00000000928.1	B5FY84	SRSF3
79		LLPS-Tag-3061	ENSTGUG00000000765.1	H0YR77	SRSF4
80		LLPS-Tag-0248	ENSTGUG00000003455.1	H0YZ37	SRSF6
81		LLPS-Tag-0985	ENSTGUG00000002095.1	H0YV42	SRSF7
82		LLPS-Tag-0564	ENSTGUG00000002600.1	H0YWQ5	STAT3
83		LLPS-Tag-1962	ENSTGUG00000010141.1	H0ZIP7	SUMO1
84		LLPS-Tag-1738	ENSTGUG00000006742.1	H0Z8P1	TRA2B
85		LLPS-Tag-1273	ENSTGUG00000010592.1	H0ZK08	TTC14
86		LLPS-Tag-3398	ENSTGUG00000008687.1	H0ZEG5	U2SURP
87		LLPS-Tag-1499	ENSTGUG00000006512.1	H0Z824	XPO1
88		LLPS-Tag-2123	ENSTGUG00000004452.1	H0Z219	YTHDC1
89		LLPS-Tag-1883	ENSTGUG00000017466.1	H1A4D2	ZC3H11A
90		LLPS-Tag-3135	ENSTGUG00000011108.1	H0ZLI1	ZNF106
91		LLPS-Tag-1537	ENSTGUG00000002273.1	H0YVM1	ZNF131