※ Nuclear speckle introduction

    Nuclear speckles or splicing speckles, also known as interchromatin granule clusters, are membrane-less nuclear organelles enriched in pre-mRNA splicing and transcription factors and play important roles in RNA metabolism, such as transcription, pre-mRNA splicing, 3′-end mRNA processing, and execution of mRNA nuclear export (1; 2). They are dynamic subnuclear structures, and their size, shape, and number can vary accompanied with RNA regulation, nuclear speckles disperse in high activity of mRNA processing when transcription or pre-mRNA splicing is inhibited, GSK-3β can regulate assembly of nuclear speckles (2). Because many naturally intronless mRNAs, including eight exogenously expressed and four endogenous ones, are proved to be associate with NSs, So Nuclear speckles (NSs) are thought to serve as splicing factor storage sites (3).

Reference
1. Lee, K. H., Zhang, P., Kim, H. J., Mitrea, D. M., Sarkar, M., Freibaum, B. D., et al. (2016) C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell, 167(3), 774-788 e717. PMID: 27768896
2. Wang, K., Wang, L., Wang, J., Chen, S., Shi, M., & Cheng, H. (2018) Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol, 217(11), 3912-3929. PMID: 30194269
3. An, Y., Zou, Y., Cao, Y., Yao, M., Ma, N., Wu, Y., et al. (2019) The nuclear GSK-3beta regulated post-transcriptional processing of mRNA through phosphorylation of SC35. Mol Cell Biochem, 451(1-2), 55-67. PMID: 30030778

  Reviewed (0)  or Unreviewed (53) 

No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Sei-0956	SETIT_030903mg	K3ZWB8	101752931
2		LLPS-Sei-1300	SETIT_030347mg	K3ZUR6	101753317
3		LLPS-Sei-0848	SETIT_025481mg	K3ZG75	101753358
4		LLPS-Sei-1214	SETIT_030222mg	K3ZUE1	101753586
5		LLPS-Sei-0134	SETIT_016507mg	K3YQG4	101754779
6		LLPS-Sei-0724	SETIT_000356mg	K3XEN9	101756107
7		LLPS-Sei-0974	SETIT_013165mg	K3YFZ8	101756394
8		LLPS-Sei-1415	SETIT_029439mg	K3ZS59	101756432
9		LLPS-Sei-1740	SETIT_029571mg	K3ZSJ1	101756970
10		LLPS-Sei-0972	SETIT_018343mg	K3YVP7	101757345
11		LLPS-Sei-0904	SETIT_016235mg	K3YPP3	101758144
12		LLPS-Sei-1317	SETIT_036837mg	K4AD80	101759327
13		LLPS-Sei-1065	SETIT_029188mg	K3ZRF8	101760612
14		LLPS-Sei-0133	SETIT_022194mg	K3Z6M5	101762124
15		LLPS-Sei-1383	SETIT_009477mg	K3Y5J0	101762369
16		LLPS-Sei-1256	SETIT_017358mg	K3YSW3	101763704
17		LLPS-Sei-1594	SETIT_006635mg	K3XXH7	101765137
18		LLPS-Sei-0429	SETIT_001545mg	K3XI23	101765576
19		LLPS-Sei-1706	SETIT_022907mg	K3Z8N7	101768233
20		LLPS-Sei-0029	SETIT_026205mg	K3ZI03	101768495
21		LLPS-Sei-1019	SETIT_035475mg	K4A9B9	101769468
22		LLPS-Sei-1703	SETIT_008881mg	K3Y3U3	101769484
23		LLPS-Sei-2263	SETIT_005659mg	K3XUQ2	101770836
24		LLPS-Sei-1379	SETIT_023008mg	K3Z8Y8	101771717
25		LLPS-Sei-0313	SETIT_016063mg	K3YP71	101772985
26		LLPS-Sei-0908	SETIT_036778mg	K4AD21	101773785
27		LLPS-Sei-0790	SETIT_018234mg	K3YVD7	101774638
28		LLPS-Sei-2150	SETIT_009268mg	K3Y4Y0	101774923
29		LLPS-Sei-1463	SETIT_002675mg	K3XLA2	101775302
30		LLPS-Sei-2016	SETIT_008220mg	K3Y201	101779853
31		LLPS-Sei-1473	SETIT_010645mg	K3Y8V3	101780741
32		LLPS-Sei-0675	SETIT_017343mg	K3YSU8	101781638
33		LLPS-Sei-1689	SETIT_022140mg	K3Z6H1	101781985
34		LLPS-Sei-0242	SETIT_010889mg	K3Y9J7	101784118
35		LLPS-Sei-0590	SETIT_036656mg	K4ACP9	101784850
36		LLPS-Sei-0127	SETIT_001134mg	K3XGW3	101786611
37		LLPS-Sei-1404	SETIT_016115mg	K3YPC2	SETIT_1G090100v2
38		LLPS-Sei-0578	SETIT_020136mg	A0A368PP93	SETIT_1G229800v2
39		LLPS-Sei-1358	SETIT_016307mg	A0A368PTY5	SETIT_1G378400v2
40		LLPS-Sei-1314	SETIT_028681mg	A0A368PVF8	SETIT_2G035600v2
41		LLPS-Sei-0668	SETIT_028775mg	A0A368PXU9	SETIT_2G111900v2
42		LLPS-Sei-0215	SETIT_005661mg	A0A368QRF3	SETIT_4G060000v2
43		LLPS-Sei-1472	SETIT_005930mg	A0A368QRG3	SETIT_4G060900v2
44		LLPS-Sei-0760	SETIT_0026452mg	K3XL72	SETIT_5G052100v2
45		LLPS-Sei-1226	SETIT_002188mg	A0A368R728	SETIT_5G210100v2
46		LLPS-Sei-1859	SETIT_027556mg	A0A368S9K0	SETIT_8G197200v2
47		LLPS-Sei-1818	SETIT_036965mg	A0A368SCH2	SETIT_9G028100v2
48		LLPS-Sei-2192	SETIT_035750mg	A0A368SK56	SETIT_9G197200v2
49		LLPS-Sei-0332	SETIT_034460mg	A0A368SJN9	SETIT_9G228900v2
50		LLPS-Sei-1025	SETIT_036407mg	A0A368SQC9	SETIT_9G389700v2
51		LLPS-Sei-1319	SETIT_039257mg	A0A368SR35	SETIT_9G410100v2
52		LLPS-Sei-1033	SETIT_036950mg	A0A368SS30	SETIT_9G436100v2
53		LLPS-Sei-0258	SETIT_036503mg	A0A368SSI9	SETIT_9G450900v2