※ Nuclear speckle introduction

    Nuclear speckles or splicing speckles, also known as interchromatin granule clusters, are membrane-less nuclear organelles enriched in pre-mRNA splicing and transcription factors and play important roles in RNA metabolism, such as transcription, pre-mRNA splicing, 3′-end mRNA processing, and execution of mRNA nuclear export (1; 2). They are dynamic subnuclear structures, and their size, shape, and number can vary accompanied with RNA regulation, nuclear speckles disperse in high activity of mRNA processing when transcription or pre-mRNA splicing is inhibited, GSK-3β can regulate assembly of nuclear speckles (2). Because many naturally intronless mRNAs, including eight exogenously expressed and four endogenous ones, are proved to be associate with NSs, So Nuclear speckles (NSs) are thought to serve as splicing factor storage sites (3).

Reference
1. Lee, K. H., Zhang, P., Kim, H. J., Mitrea, D. M., Sarkar, M., Freibaum, B. D., et al. (2016) C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell, 167(3), 774-788 e717. PMID: 27768896
2. Wang, K., Wang, L., Wang, J., Chen, S., Shi, M., & Cheng, H. (2018) Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol, 217(11), 3912-3929. PMID: 30194269
3. An, Y., Zou, Y., Cao, Y., Yao, M., Ma, N., Wu, Y., et al. (2019) The nuclear GSK-3beta regulated post-transcriptional processing of mRNA through phosphorylation of SC35. Mol Cell Biochem, 451(1-2), 55-67. PMID: 30030778

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No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Sem-1176	SELMODRAFT_169846
2		LLPS-Sem-0012	SELMODRAFT_100958	D8RT90	CDKD-1
3		LLPS-Sem-0154	SELMODRAFT_171333	D8RGE3	COP1-1
4		LLPS-Sem-1170	SELMODRAFT_159063	D8SX29	GSK1-1
5		LLPS-Sem-0259	SELMODRAFT_437541	D8QMX0	PUB59-1
6		LLPS-Sem-0364	SELMODRAFT_100233	D8RRX3	SELMODRAFT_100233
7		LLPS-Sem-0986	SELMODRAFT_102224	D8RUC6	SELMODRAFT_102224
8		LLPS-Sem-1608	SELMODRAFT_106721	D8S1X0	SELMODRAFT_106721
9		LLPS-Sem-0844	SELMODRAFT_110199	D8S7B4	SELMODRAFT_110199
10		LLPS-Sem-1031	SELMODRAFT_114956	D8SEI1	SELMODRAFT_114956
11		LLPS-Sem-1613	SELMODRAFT_115108	D8SEF0	SELMODRAFT_115108
12		LLPS-Sem-0125	SELMODRAFT_115473	D8SF73	SELMODRAFT_115473
13		LLPS-Sem-1800	SELMODRAFT_117870	D8SJ38	SELMODRAFT_117870
14		LLPS-Sem-2353	SELMODRAFT_75683	D8QPB9	SELMODRAFT_119432
15		LLPS-Sem-1828	SELMODRAFT_119537	D8SKN7	SELMODRAFT_119537
16		LLPS-Sem-1484	SELMODRAFT_98131	D8RPB2	SELMODRAFT_120430
17		LLPS-Sem-1633	SELMODRAFT_129290	D8T0R6	SELMODRAFT_129290
18		LLPS-Sem-0301	SELMODRAFT_129703	D8SC78	SELMODRAFT_129703
19		LLPS-Sem-2204	SELMODRAFT_13030	D8S917	SELMODRAFT_13030
20		LLPS-Sem-0868	SELMODRAFT_131763	D8T4H2	SELMODRAFT_131763
21		LLPS-Sem-0464	SELMODRAFT_134332	D8T8C2	SELMODRAFT_134332
22		LLPS-Sem-0678	SELMODRAFT_136263	D8TBL3	SELMODRAFT_136263
23		LLPS-Sem-0304	SELMODRAFT_137537	D8TDU4	SELMODRAFT_137537
24		LLPS-Sem-1149	SELMODRAFT_144158	D8R544	SELMODRAFT_144158
25		LLPS-Sem-0329	SELMODRAFT_146605	D8RF49	SELMODRAFT_146605
26		LLPS-Sem-0136	SELMODRAFT_146823	D8RFZ4	SELMODRAFT_146823
27		LLPS-Sem-2165	SELMODRAFT_149478	D8RSE2	SELMODRAFT_149478
28		LLPS-Sem-1871	SELMODRAFT_160385	D8T2C4	SELMODRAFT_160385
29		LLPS-Sem-0250	SELMODRAFT_163366	D8TF04	SELMODRAFT_163366
30		LLPS-Sem-0041	SELMODRAFT_171839	D8QRX0	SELMODRAFT_171839
31		LLPS-Sem-0567	SELMODRAFT_173603	D8RRR0	SELMODRAFT_173603
32		LLPS-Sem-0332	SELMODRAFT_179572	D8SGR2	SELMODRAFT_179572
33		LLPS-Sem-1045	SELMODRAFT_230014	D8QRA6	SELMODRAFT_230014
34		LLPS-Sem-1282	SELMODRAFT_233936	D8SFW6	SELMODRAFT_233936
35		LLPS-Sem-0020	SELMODRAFT_236385	D8T867	SELMODRAFT_236385
36		LLPS-Sem-1758	SELMODRAFT_270930	D8RLK8	SELMODRAFT_270930
37		LLPS-Sem-0122	SELMODRAFT_36388	D8S859	SELMODRAFT_36388
38		LLPS-Sem-0601	SELMODRAFT_38959	D8QMV3	SELMODRAFT_38959
39		LLPS-Sem-0708	SELMODRAFT_407718	D8R6J1	SELMODRAFT_407718
40		LLPS-Sem-0347	SELMODRAFT_420412	D8SBX3	SELMODRAFT_420412
41		LLPS-Sem-0497	SELMODRAFT_420821	D8SD82	SELMODRAFT_420821
42		LLPS-Sem-0212	SELMODRAFT_424875	D8SRA5	SELMODRAFT_424875
43		LLPS-Sem-0552	SELMODRAFT_431145	D8TBN6	SELMODRAFT_431145
44		LLPS-Sem-2024	SELMODRAFT_441325	D8RIL4	SELMODRAFT_441325
45		LLPS-Sem-1100	SELMODRAFT_445375	D8SI36	SELMODRAFT_445375
46		LLPS-Sem-1477	SELMODRAFT_446978	D8SVT1	SELMODRAFT_446978
47		LLPS-Sem-0481	SELMODRAFT_6302	D8S7H9	SELMODRAFT_6302
48		LLPS-Sem-1649	SELMODRAFT_6997	D8SNL1	SELMODRAFT_7006
49		LLPS-Sem-1896	SELMODRAFT_73732	D8QN19	SELMODRAFT_73732
50		LLPS-Sem-1990	SELMODRAFT_74095	D8QNY1	SELMODRAFT_74095
51		LLPS-Sem-1113	SELMODRAFT_8400	D8RPG8	SELMODRAFT_8400
52		LLPS-Sem-1354	SELMODRAFT_85327	D8R633	SELMODRAFT_85327
53		LLPS-Sem-0419	SELMODRAFT_87004	D8R7W2	SELMODRAFT_87004
54		LLPS-Sem-0361	SELMODRAFT_97336	D8RMG5	SELMODRAFT_97336