※ Nuclear speckle introduction

    Nuclear speckles or splicing speckles, also known as interchromatin granule clusters, are membrane-less nuclear organelles enriched in pre-mRNA splicing and transcription factors and play important roles in RNA metabolism, such as transcription, pre-mRNA splicing, 3′-end mRNA processing, and execution of mRNA nuclear export (1; 2). They are dynamic subnuclear structures, and their size, shape, and number can vary accompanied with RNA regulation, nuclear speckles disperse in high activity of mRNA processing when transcription or pre-mRNA splicing is inhibited, GSK-3β can regulate assembly of nuclear speckles (2). Because many naturally intronless mRNAs, including eight exogenously expressed and four endogenous ones, are proved to be associate with NSs, So Nuclear speckles (NSs) are thought to serve as splicing factor storage sites (3).

Reference
1. Lee, K. H., Zhang, P., Kim, H. J., Mitrea, D. M., Sarkar, M., Freibaum, B. D., et al. (2016) C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell, 167(3), 774-788 e717. PMID: 27768896
2. Wang, K., Wang, L., Wang, J., Chen, S., Shi, M., & Cheng, H. (2018) Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol, 217(11), 3912-3929. PMID: 30194269
3. An, Y., Zou, Y., Cao, Y., Yao, M., Ma, N., Wu, Y., et al. (2019) The nuclear GSK-3beta regulated post-transcriptional processing of mRNA through phosphorylation of SC35. Mol Cell Biochem, 451(1-2), 55-67. PMID: 30030778

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No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Ast-1154	ATEG_00094	Q0D1U0	ATEG_00094
2		LLPS-Ast-0233	ATEG_00262	Q0D1C2	ATEG_00262
3		LLPS-Ast-0604	ATEG_01362	Q0CY72	ATEG_01362
4		LLPS-Ast-0703	ATEG_01657	Q0CXC7	ATEG_01657
5		LLPS-Ast-0676	ATEG_01819	Q0CWW5	ATEG_01819
6		LLPS-Ast-1270	ATEG_02080	Q0CW54	ATEG_02080
7		LLPS-Ast-0544	ATEG_02578	Q0CUQ6	ATEG_02578
8		LLPS-Ast-1152	ATEG_02771	Q0CU63	ATEG_02771
9		LLPS-Ast-0060	ATEG_02848	Q0CTY6	ATEG_02848
10		LLPS-Ast-0063	ATEG_02977	Q0CTK7	ATEG_02977
11		LLPS-Ast-1038	ATEG_03877	Q0CR07	ATEG_03877
12		LLPS-Ast-0774	ATEG_04577	Q0CP07	ATEG_04577
13		LLPS-Ast-0280	ATEG_05773	Q0CKL1	ATEG_05773
14		LLPS-Ast-0598	ATEG_06157	Q0CJH7	ATEG_06157
15		LLPS-Ast-1334	ATEG_06160	Q0CJH4	ATEG_06160
16		LLPS-Ast-0033	ATEG_06432	Q0CIQ2	ATEG_06432
17		LLPS-Ast-0449	ATEG_06433	Q0CIQ1	ATEG_06433
18		LLPS-Ast-0300	ATEG_06451	Q0CIN3	ATEG_06451
19		LLPS-Ast-0476	ATEG_06741	Q0CHU3	ATEG_06741
20		LLPS-Ast-1132	ATEG_07405	Q0CFX9	ATEG_07405
21		LLPS-Ast-0381	ATEG_07424	Q0CFW0	ATEG_07424
22		LLPS-Ast-0066	ATEG_07657	Q0CF77	ATEG_07657
23		LLPS-Ast-0207	ATEG_08495	Q0CCT9	ATEG_08495
24		LLPS-Ast-0643	ATEG_08572	Q0CCL2	ATEG_08572
25		LLPS-Ast-0925	ATEG_08780	Q0CC04	ATEG_08780
26		LLPS-Ast-0595	ATEG_09207	Q0CAS7	ATEG_09207
27		LLPS-Ast-0663	ATEG_09591	Q0C9P3	ATEG_09591
28		LLPS-Ast-0826	ATEG_09705	Q0C9C9	ATEG_09705
29		LLPS-Ast-1377	ATEG_09718	Q0C9B6	ATEG_09718