Otolemur garnettii Nuclear pore complex
※ Nuclear pore complex introduction The nuclear pore is proposed to be a LLPS stress granules initially condense to form stable cores, possibly with a nascent shell layer, and these cores merge into larger structures through interactions between the shell structures (1). A stable core assemblies could provide a structural platform for the formation of stress granules, due to the high concentration of IDRs on stress granule components to then rapidly phase-separate a dynamic shell that grows as a result of fusion with other small granules and surface exchange with an increasing pool of untranslating mRNPs. This general principle is also seen in the formation of the nuclear pore, wherein the creation of a high local concentration of FG repeat proteins by the structure of the nuclear pore, allows for a phase transition within the nuclear pore itself, even if the interactions between the FG repeats are relatively weak and non-specific (1). Reference
1. Wheeler, J. R., Matheny, T., Jain, S., Abrisch, R., & Parker, R. (2016) Distinct stages in stress granule assembly and disassembly. Elife, 5. PMID: 27602576
There are 2 genes. Reviewed (0)
or Unreviewed (2) 
※ Nuclear pore complex introduction The nuclear pore is proposed to be a LLPS stress granules initially condense to form stable cores, possibly with a nascent shell layer, and these cores merge into larger structures through interactions between the shell structures (1). A stable core assemblies could provide a structural platform for the formation of stress granules, due to the high concentration of IDRs on stress granule components to then rapidly phase-separate a dynamic shell that grows as a result of fusion with other small granules and surface exchange with an increasing pool of untranslating mRNPs. This general principle is also seen in the formation of the nuclear pore, wherein the creation of a high local concentration of FG repeat proteins by the structure of the nuclear pore, allows for a phase transition within the nuclear pore itself, even if the interactions between the FG repeats are relatively weak and non-specific (1). Reference
1. Wheeler, J. R., Matheny, T., Jain, S., Abrisch, R., & Parker, R. (2016) Distinct stages in stress granule assembly and disassembly. Elife, 5. PMID: 27602576
There are 2 genes. Reviewed (0)
or Unreviewed (2) | No. | Status | DrLLPS ID | Ensemble Gene ID | UniProt Accession | Gene Name |
|---|---|---|---|---|---|
| 1 | | ||||
| 2 | |