※ Nuclear pore complex introduction

    The nuclear pore is proposed to be a LLPS stress granules initially condense to form stable cores, possibly with a nascent shell layer, and these cores merge into larger structures through interactions between the shell structures (1). A stable core assemblies could provide a structural platform for the formation of stress granules, due to the high concentration of IDRs on stress granule components to then rapidly phase-separate a dynamic shell that grows as a result of fusion with other small granules and surface exchange with an increasing pool of untranslating mRNPs. This general principle is also seen in the formation of the nuclear pore, wherein the creation of a high local concentration of FG repeat proteins by the structure of the nuclear pore, allows for a phase transition within the nuclear pore itself, even if the interactions between the FG repeats are relatively weak and non-specific (1).

Reference
1. Wheeler, J. R., Matheny, T., Jain, S., Abrisch, R., & Parker, R. (2016) Distinct stages in stress granule assembly and disassembly. Elife, 5. PMID: 27602576

  Reviewed (0)  or Unreviewed (3) 

No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Fuv-1253	FVEG_02157
2		LLPS-Fuv-1330	FVEG_05141	W7M8E9	FVEG_05141
3		LLPS-Fuv-0132	FVEG_02158	W7LL61	FVEG_14988