Takifugu rubripes      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 36 genes.  Reviewed (0 or Unreviewed (36

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Tar-1526
ENSTRUG00000019904.1
A0A3B5K9E2
2
LLPS-Tar-2506
ENSTRUG00000017015.2
A0A3B5KAS0
3
LLPS-Tar-2735
ENSTRUG00000024045.1
A0A3B5K6X6
4
LLPS-Tar-2341
ENSTRUG00000017061.2
H2V3C7
caprin1
5
LLPS-Tar-2458
ENSTRUG00000010692.2
H2TQL8
CPEB4 (1 of many)
6
LLPS-Tar-1070
ENSTRUG00000015765.2
H2UTK8
ddx1
7
LLPS-Tar-1129
ENSTRUG00000002356.2
H2RZ56
DDX5
8
LLPS-Tar-0749
ENSTRUG00000002918.2
H2S336
eif2a
9
LLPS-Tar-1333
ENSTRUG00000017958.2
H2V9Z7
eif2s1
10
LLPS-Tar-0059
ENSTRUG00000002676.2
H2S1H3
eif2s2
11
LLPS-Tar-3896
ENSTRUG00000000523.2
H2RM79
elavl4
12
LLPS-Tar-2016
ENSTRUG00000021926.1
A0A3B5KC71
ewsr1
13
LLPS-Tar-1716
ENSTRUG00000003486.2
H2S708
fxr1
14
LLPS-Tar-3091
ENSTRUG00000008411.2
H2T8S3
hnrnpab
15
LLPS-Tar-1161
ENSTRUG00000007759.2
A0A3B5JZ99
hnrnpu
16
LLPS-Tar-0189
ENSTRUG00000010001.2
H2TKF9
LOC101062326
17
LLPS-Tar-0687
ENSTRUG00000012893.2
H2U6U7
LOC101063194
18
LLPS-Tar-1277
ENSTRUG00000013160.2
H2U959
LOC101064460
19
LLPS-Tar-0694
ENSTRUG00000000144.2
H2RJI8
LOC101065127
20
LLPS-Tar-1670
ENSTRUG00000018450.2
H2VDE0
LOC101066421
21
LLPS-Tar-3848
ENSTRUG00000008860.2
H2TC78
LOC101068244
22
LLPS-Tar-a055
ENSTRUG00000008695.2
H2TAZ2
LOC101069650
23
LLPS-Tar-0523
ENSTRUG00000011335.2
H2TV99
LOC101071804
24
LLPS-Tar-2186
ENSTRUG00000015362.2
H2UQN7
LOC101078929
25
LLPS-Tar-1267
ENSTRUG00000024250.1
A0A3B5JVZ2
LOC101079607
26
LLPS-Tar-0562
ENSTRUG00000008185.2
H2T744
ncl
27
LLPS-Tar-0181
ENSTRUG00000005554.2
H2SLS9
nono
28
LLPS-Tar-0071
ENSTRUG00000000041.2
H2RIY6
RBPMS
29
LLPS-Tar-2433
ENSTRUG00000001883.2
A0A3B5KF34
ripk4
30
LLPS-Tar-3789
ENSTRUG00000009880.2
H2TJF4
RTCB
31
LLPS-Tar-0474
ENSTRUG00000022455.1
A0A3B5K9T5
rtraf
32
LLPS-Tar-0669
ENSTRUG00000003783.2
H2S920
sfpq
33
LLPS-Tar-1051
ENSTRUG00000005837.2
H2SP91
stau1
34
LLPS-Tar-0866
ENSTRUG00000001905.2
H2RW62
stau2
35
LLPS-Tar-1837
ENSTRUG00000005365.2
A0A3B5K4X5
syncrip
36
LLPS-Tar-2452
ENSTRUG00000007701.2
H2T391
trim2