Taeniopygia guttata      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 39 genes.  Reviewed (0 or Unreviewed (39

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Tag-0235
ENSTGUG00000012478.1
H0ZQF9
2
LLPS-Tag-0246
ENSTGUG00000008103.1
H0ZCT0
3
LLPS-Tag-1133
ENSTGUG00000006442.1
H0Z7X4
4
LLPS-Tag-1640
ENSTGUG00000009782.1
H0ZHN1
5
LLPS-Tag-2162
ENSTGUG00000001178.1
H0YSG1
6
LLPS-Tag-3542
ENSTGUG00000003513.1
H0YZ89
ALYREF
7
LLPS-Tag-0015
ENSTGUG00000014953.1
H0ZXF5
CAPRIN1
8
LLPS-Tag-0810
ENSTGUG00000000329.1
H0YPY7
CPEB4
9
LLPS-Tag-0868
ENSTGUG00000013096.1
H0ZS97
DDX1
10
LLPS-Tag-0043
ENSTGUG00000004622.1
H0Z2K1
DDX5
11
LLPS-Tag-0475
ENSTGUG00000012670.1
H0ZR08
EEF1A1
12
LLPS-Tag-1469
ENSTGUG00000011386.1
H0ZMC1
EIF2A
13
LLPS-Tag-1114
ENSTGUG00000011542.1
H0ZMS9
EIF2S1
14
LLPS-Tag-0541
ENSTGUG00000003689.1
H0YZT3
EIF2S2
15
LLPS-Tag-0301
ENSTGUG00000003296.1
H0YYN4
EIF4E
16
LLPS-Tag-0591
ENSTGUG00000008597.1
H0ZE51
ELAVL4
17
LLPS-Tag-1079
ENSTGUG00000010419.1
H0ZJJ7
EWSR1
18
LLPS-Tag-2305
ENSTGUG00000004735.1
H0Z2U8
FMR1
19
LLPS-Tag-1126
ENSTGUG00000010560.1
H0ZJZ2
FXR1
20
LLPS-Tag-0339
ENSTGUG00000000753.1
H0YR71
G3BP1
21
LLPS-Tag-1540
ENSTGUG00000001186.1
H0YSG3
HNRNPA0
22
LLPS-Tag-0517
ENSTGUG00000002869.1
H0YXD2
HNRNPA2B1
23
LLPS-Tag-2627
ENSTGUG00000001168.1
H0YSE3
HNRNPAB
24
LLPS-Tag-0179
ENSTGUG00000002858.1
H0YXC8
HNRNPD
25
LLPS-Tag-0095
ENSTGUG00000008309.1
H0ZDE9
HNRNPU
26
LLPS-Tag-0062
ENSTGUG00000007048.1
H0Z9M5
NONO
27
LLPS-Tag-a058
ENSTGUG00000007566.1
H0ZB62
PSD
28
LLPS-Tag-0946
ENSTGUG00000011295.1
H0ZM27
PSPC1
29
LLPS-Tag-1052
ENSTGUG00000001628.1
H0YTR0
PURA
30
LLPS-Tag-1246
ENSTGUG00000001776.1
H0YU64
RBPMS
31
LLPS-Tag-3650
ENSTGUG00000005420.1
H0Z4T9
RIPK4
32
LLPS-Tag-0374
ENSTGUG00000010248.1
H0ZJ17
RPL3
33
LLPS-Tag-1819
ENSTGUG00000010947.1
H0ZL18
RTCB
34
LLPS-Tag-0004
ENSTGUG00000013128.1
H0ZSC7
RTRAF
35
LLPS-Tag-1317
ENSTGUG00000001722.1
H0YU18
SFPQ
36
LLPS-Tag-1005
ENSTGUG00000008784.1
H0ZES0
STAU1
37
LLPS-Tag-0996
ENSTGUG00000011535.1
H0ZMT5
STAU2
38
LLPS-Tag-3505
ENSTGUG00000005081.1
H0Z3W5
TRIM2
39
LLPS-Tag-3458
ENSTGUG00000000602.1
H0YQR0
TRIM3