Danio rerio      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 34 genes.  Reviewed (0 or Unreviewed (34

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Dar-0275
ENSDARG00000038068.9
2
LLPS-Dar-0204
ENSDARG00000054272.6
A5WVQ1
caprin1b
3
LLPS-Dar-1345
ENSDARG00000100499.2
A0A0G2KYC0
cpeb4b
4
LLPS-Dar-1772
ENSDARG00000032117.11
F1R2L8
ddx1
5
LLPS-Dar-2646
ENSDARG00000069951.6
Q92005
eef1a
6
LLPS-Dar-0056
ENSDARG00000101061.2
Q4QRJ7
eif2a
7
LLPS-Dar-0256
ENSDARG00000052178.4
Q9I9E9
eif2s1b
8
LLPS-Dar-0844
ENSDARG00000053047.3
F1Q8P7
eif2s2
9
LLPS-Dar-0764
ENSDARG00000013274.8
B8JIA7
eif4eb
10
LLPS-Dar-0099
ENSDARG00000045639.8
A0A0R4IEW8
elavl4
11
LLPS-Dar-2944
ENSDARG00000020465.10
Q4QRG0
ewsr1b
12
LLPS-Dar-1352
ENSDARG00000116730.1
A0A2R8RJS5
fxr2
13
LLPS-Dar-0454
ENSDARG00000017741.8
Q6P124
g3bp1
14
LLPS-Dar-2203
ENSDARG00000036161.8
Q7ZU48
hnrnpa0l
15
LLPS-Dar-1920
ENSDARG00000099865.2
Q6NYA1
hnrnpabb
16
LLPS-Dar-1413
ENSDARG00000113453.1
A0A2R8QRA0
hnrnpd
17
LLPS-Dar-1416
ENSDARG00000004735.12
Q5RHQ7
hnrnpub
18
LLPS-Dar-3549
ENSDARG00000070475.5
Q6NW62
khdrbs1b
19
LLPS-Dar-0715
ENSDARG00000020482.10
Q802Z5
nono
20
LLPS-Dar-a1057
ENSDARG00000078102.5
A0A2R8RNF7
psda
21
LLPS-Dar-0629
ENSDARG00000006621.11
Q1JPY8
pspc1
22
LLPS-Dar-1931
ENSDARG00000067591.5
Q6JIZ2
puraa
23
LLPS-Dar-0157
ENSDARG00000043211.7
A0A2R8Q9U3
ripk4
24
LLPS-Dar-2469
ENSDARG00000003599.10
Q5BJJ2
rpl3
25
LLPS-Dar-3940
ENSDARG00000101047.2
Q6NZS4
rtcb
26
LLPS-Dar-2579
ENSDARG00000009253.9
Q7ZUH1
rtraf
27
LLPS-Dar-1338
ENSDARG00000011564.11
Q1L8R2
sfpq
28
LLPS-Dar-0818
ENSDARG00000086411.3
Q7SZS0
srsf10b
29
LLPS-Dar-0712
ENSDARG00000115476.1
A0A2R8Q731
stau1
30
LLPS-Dar-0957
ENSDARG00000026801.10
Q7ZW47
stau2
31
LLPS-Dar-0732
ENSDARG00000026723.10
Q6NYJ5
syncripl
32
LLPS-Dar-2906
ENSDARG00000031817.8
F1QFW2
trim2a
33
LLPS-Dar-2046
ENSDARG00000005397.11
A0A286YB14
trim3b
34
LLPS-Dar-3116
ENSDARG00000009899.11
E7EZH0
znf385a