Chlorocebus sabaeus      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 43 genes.  Reviewed (2 or Unreviewed (41

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Chs-0000
ENSCSAG00000010876.1
A0A0D9REQ6
G3BP1
2
LLPS-Chs-0004
ENSCSAG00000001082.1
A0A0D9S7U2
SFPQ
3
LLPS-Chs-0035
ENSCSAG00000002626.1
A0A0D9S3H8
4
LLPS-Chs-0099
ENSCSAG00000013572.1
A0A0D9RM49
5
LLPS-Chs-0450
ENSCSAG00000012138.1
A0A0D9RI83
6
LLPS-Chs-1996
ENSCSAG00000019608.1
A0A0D9SE18
7
LLPS-Chs-3254
ENSCSAG00000005436.1
A0A0D9QZF1
8
LLPS-Chs-0428
ENSCSAG00000002216.1
A0A0D9S4M9
ALYREF
9
LLPS-Chs-0397
ENSCSAG00000005378.1
A0A0D9QZA0
CAPRIN1
10
LLPS-Chs-0156
ENSCSAG00000012245.1
A0A0D9RIJ2
CIRBP
11
LLPS-Chs-3212
ENSCSAG00000009516.1
A0A0D9RAY2
CPEB4
12
LLPS-Chs-1810
ENSCSAG00000007883.1
A0A0D9R6A2
DDX1
13
LLPS-Chs-2023
ENSCSAG00000004022.1
A0A0D9QVI6
DDX5
14
LLPS-Chs-0018
ENSCSAG00000014041.1
A0A0D9RNJ1
EEF1A1
15
LLPS-Chs-2297
ENSCSAG00000011568.1
A0A0D9RGM4
EIF2A
16
LLPS-Chs-0816
ENSCSAG00000013324.1
A0A0D9RLK1
EIF2S1
17
LLPS-Chs-1517
ENSCSAG00000004122.1
A0A0D9QVU1
EIF4E
18
LLPS-Chs-0118
ENSCSAG00000001257.1
A0A0D9S7B8
ELAVL4
19
LLPS-Chs-2848
ENSCSAG00000009820.1
A0A0D9RBS5
EWSR1
20
LLPS-Chs-3074
ENSCSAG00000007281.1
A0A0D9R4K7
FMR1
21
LLPS-Chs-2736
ENSCSAG00000013179.1
A0A0D9RL59
FXR1
22
LLPS-Chs-0587
ENSCSAG00000011386.1
A0A0D9RG49
FXR2
23
LLPS-Chs-2377
ENSCSAG00000000499.1
A0A0D9S9G6
HNRNPA0
24
LLPS-Chs-2277
ENSCSAG00000014175.1
A0A0D9RNX3
HNRNPA2B1
25
LLPS-Chs-2751
ENSCSAG00000004463.1
A0A0D9QWR4
HNRNPD
26
LLPS-Chs-2877
ENSCSAG00000009219.1
A0A0D9RA32
HNRNPU
27
LLPS-Chs-4062
ENSCSAG00000001043.1
A0A0D9S7Y1
KHDRBS1
28
LLPS-Chs-2292
ENSCSAG00000006660.1
A0A0D9R2V4
NCL
29
LLPS-Chs-1435
ENSCSAG00000011364.1
A0A0D9RG28
NONO
30
LLPS-Chs-a064
ENSCSAG00000005438.1
A0A0D9QZG0
PSD
31
LLPS-Chs-0847
ENSCSAG00000018095.1
A0A0D9RZS5
PSPC1
32
LLPS-Chs-0399
ENSCSAG00000000495.1
A0A0D9S9H0
PURA
33
LLPS-Chs-3718
ENSCSAG00000013242.1
A0A0D9RLC1
RBM3
34
LLPS-Chs-2291
ENSCSAG00000015838.1
A0A0D9RTH8
RBPMS
35
LLPS-Chs-4816
ENSCSAG00000008221.1
A0A0D9R792
RIPK4
36
LLPS-Chs-1870
ENSCSAG00000008351.1
A0A0D9R7L4
RTCB
37
LLPS-Chs-3210
ENSCSAG00000015068.1
A0A0D9RRD3
RTRAF
38
LLPS-Chs-3490
ENSCSAG00000000935.1
A0A0D9S884
SRSF10
39
LLPS-Chs-0313
ENSCSAG00000014986.1
A0A0D9RR49
STAU1
40
LLPS-Chs-1206
ENSCSAG00000017365.1
A0A0D9RXQ9
SYNCRIP
41
LLPS-Chs-0597
ENSCSAG00000003302.1
A0A0D9S1K5
TRIM2
42
LLPS-Chs-0490
ENSCSAG00000004321.1
A0A0D9QWC7
TRIM3
43
LLPS-Chs-2458
ENSCSAG00000005407.1
A0A0D9QZC7
ZNF385A