Anas platyrhynchos      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 32 genes.  Reviewed (0 or Unreviewed (32

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Anp-2309
ENSAPLG00000014745.1
U3J509
2
LLPS-Anp-0537
ENSAPLG00000006975.1
U3IHE3
CAPRIN1
3
LLPS-Anp-1875
ENSAPLG00000011093.1
U3IUN2
DDX1
4
LLPS-Anp-1313
ENSAPLG00000014240.1
U3J3R0
DDX3X
5
LLPS-Anp-0199
ENSAPLG00000009071.1
U3INI1
DDX5
6
LLPS-Anp-1931
ENSAPLG00000010076.1
U3IRH1
EIF2A
7
LLPS-Anp-0273
ENSAPLG00000014974.1
R0M310
EIF2S1
8
LLPS-Anp-0486
ENSAPLG00000013245.1
R0JVX6
EIF2S2
9
LLPS-Anp-1803
ENSAPLG00000015915.1
U3J8H9
EIF4E
10
LLPS-Anp-1528
ENSAPLG00000002634.1
U3I4C9
ELAVL4
11
LLPS-Anp-0142
ENSAPLG00000003811.1
U3I7X8
FMR1
12
LLPS-Anp-0452
ENSAPLG00000010032.1
U3IRF4
FXR1
13
LLPS-Anp-1034
ENSAPLG00000006581.1
U3IG64
G3BP1
14
LLPS-Anp-0560
ENSAPLG00000012019.1
U3IX39
HNRNPA2B1
15
LLPS-Anp-0027
ENSAPLG00000014040.1
U3J2Z0
HNRNPAB
16
LLPS-Anp-0988
ENSAPLG00000011849.1
U3IWL4
HNRNPD
17
LLPS-Anp-1742
ENSAPLG00000012268.1
U3IXT5
HNRNPU
18
LLPS-Anp-1886
ENSAPLG00000006587.1
R0LFK1
KHDRBS1
19
LLPS-Anp-0236
ENSAPLG00000016448.1
U3JA23
MAPK8
20
LLPS-Anp-1123
ENSAPLG00000012897.1
U3IZP7
NCL
21
LLPS-Anp-0358
ENSAPLG00000002642.1
R0K1I0
NONO
22
LLPS-Anp-a055
ENSAPLG00000014121.1
U3J369
PSD
23
LLPS-Anp-0721
ENSAPLG00000006246.1
U3IF36
PSPC1
24
LLPS-Anp-2464
ENSAPLG00000016253.1
U3J9G6
RIPK4
25
LLPS-Anp-1027
ENSAPLG00000014599.1
U3J4P9
RPL3
26
LLPS-Anp-0690
ENSAPLG00000008226.1
U3IKV0
RTCB
27
LLPS-Anp-2831
ENSAPLG00000016032.1
R0LMH6
RTRAF
28
LLPS-Anp-1320
ENSAPLG00000005446.1
U3ICM4
SRSF10
29
LLPS-Anp-0493
ENSAPLG00000010527.1
R0K108
STAU1
30
LLPS-Anp-0907
ENSAPLG00000005175.1
U3IC06
STAU2
31
LLPS-Anp-2038
ENSAPLG00000009918.1
U3IQY3
SYNCRIP
32
LLPS-Anp-2009
ENSAPLG00000001980.1
U3I2H5
TRIM2