Saccharomyces cerevisiae      Mitochondrial RNA granule


※ Mitochondrial RNA granule introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Mitochondrial RNA granules is a kind of these bodies of spherical shape that located in mitochondria with mitochondrial mRNAs and mitochondrial ribosomes components and it’s proved to be related to the posttranscriptional RNA processing and biogenesis of mitochondrial ribosomes (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 6 genes.  Reviewed (1 or Unreviewed (5

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Sac-0022
YFL036W
P13433
RPO41
2
LLPS-Sac-1208
YOR201C
P25270
MRM1
3
LLPS-Sac-0891
YBR146W
P38120
MRPS9
4
LLPS-Sac-1376
YPL104W
P15179
MSD1
5
LLPS-Sac-1414
YPL029W
P32580
SUV3
6
LLPS-Sac-1177
YPR024W
P32795
YME1