Monodelphis domestica      Mitochondrial RNA granule


※ Mitochondrial RNA granule introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Mitochondrial RNA granules is a kind of these bodies of spherical shape that located in mitochondria with mitochondrial mRNAs and mitochondrial ribosomes components and it’s proved to be related to the posttranscriptional RNA processing and biogenesis of mitochondrial ribosomes (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 39 genes.  Reviewed (0 or Unreviewed (39

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mod-0901
ENSMODG00000012822.3
F7DD82
2
LLPS-Mod-4186
ENSMODG00000011975.3
F7B9Y3
3
LLPS-Mod-3825
ENSMODG00000018926.2
F7GJV5
AARS2
4
LLPS-Mod-3207
ENSMODG00000004188.3
F6Y9Y7
DARS2
5
LLPS-Mod-4330
ENSMODG00000005303.2
F7DMJ8
DDX28
6
LLPS-Mod-1768
ENSMODG00000014285.3
F6WKE0
DHX30
7
LLPS-Mod-1691
ENSMODG00000019305.3
F6RYG3
ERAL1
8
LLPS-Mod-3259
ENSMODG00000008073.3
F6YJQ6
FASTKD1
9
LLPS-Mod-3817
ENSMODG00000015997.3
F7EZ09
FASTKD2
10
LLPS-Mod-0388
ENSMODG00000019088.3
F7FNC0
GRSF1
11
LLPS-Mod-2246
ENSMODG00000020889.2
H9H7Q1
HSD17B10
12
LLPS-Mod-1750
ENSMODG00000000088.3
F6Q901
MCU
13
LLPS-Mod-2487
ENSMODG00000010968.3
F7BC34
ME2
14
LLPS-Mod-3195
ENSMODG00000003307.2
F7DZ27
MRM1
15
LLPS-Mod-3698
ENSMODG00000010029.3
F6TUK5
MRM3
16
LLPS-Mod-1606
ENSMODG00000007969.3
F7DQT5
MRPL19
17
LLPS-Mod-1671
ENSMODG00000021301.3
F7G3T0
MRPL47
18
LLPS-Mod-3608
ENSMODG00000001687.3
F6S7T5
MRPS27
19
LLPS-Mod-2214
ENSMODG00000010347.3
F6S8D0
MRPS31
20
LLPS-Mod-0533
ENSMODG00000007290.3
F7FCF7
MRPS7
21
LLPS-Mod-1497
ENSMODG00000002479.3
F7BVW6
MRPS9
22
LLPS-Mod-4037
ENSMODG00000006966.3
F6QV92
MTERF3
23
LLPS-Mod-2733
ENSMODG00000007924.3
F7GIA7
MTPAP
24
LLPS-Mod-0768
ENSMODG00000013249.3
F7DUM2
NLRX1
25
LLPS-Mod-1812
ENSMODG00000020703.3
F7D1E1
NOA1
26
LLPS-Mod-2302
ENSMODG00000017224.3
F6WXQ5
PMPCB
27
LLPS-Mod-4310
ENSMODG00000001984.2
F6RID9
PNPT1
28
LLPS-Mod-2071
ENSMODG00000006478.3
F7FG73
POLRMT
29
LLPS-Mod-2621
ENSMODG00000001350.3
F7FW99
PTCD1
30
LLPS-Mod-2518
ENSMODG00000001695.2
F6S7F6
PTCD2
31
LLPS-Mod-2735
ENSMODG00000005210.2
F7A209
RPUSD3
32
LLPS-Mod-3810
ENSMODG00000004521.2
F6UR33
RPUSD4
33
LLPS-Mod-3573
ENSMODG00000003294.3
F7EG06
SUCLG2
34
LLPS-Mod-3625
ENSMODG00000010700.3
H9H6E6
SUPV3L1
35
LLPS-Mod-3443
ENSMODG00000008169.3
F7EKY1
TFB1M
36
LLPS-Mod-4067
ENSMODG00000025175.2
F7FXF7
TRMT10C
37
LLPS-Mod-3807
ENSMODG00000005940.2
F6WW62
TRUB2
38
LLPS-Mod-4315
ENSMODG00000011966.2
F7CUW8
TWNK
39
LLPS-Mod-2889
ENSMODG00000008389.3
F7BVC8
YME1L1