Latimeria chalumnae      Mitochondrial RNA granule


※ Mitochondrial RNA granule introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Mitochondrial RNA granules is a kind of these bodies of spherical shape that located in mitochondria with mitochondrial mRNAs and mitochondrial ribosomes components and it’s proved to be related to the posttranscriptional RNA processing and biogenesis of mitochondrial ribosomes (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 36 genes.  Reviewed (0 or Unreviewed (36

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Lac-0240
ENSLACG00000011843.2
H3AUY3
DARS2
2
LLPS-Lac-1034
ENSLACG00000005578.2
H3A9G7
DDX28
3
LLPS-Lac-1969
ENSLACG00000009404.1
H3AM04
DHX30
4
LLPS-Lac-3180
ENSLACG00000012328.1
H3AWI1
ERAL1
5
LLPS-Lac-2427
ENSLACG00000010865.1
H3ARR7
FASTK
6
LLPS-Lac-2549
ENSLACG00000012404.1
H3AWS1
FASTKD1
7
LLPS-Lac-0697
ENSLACG00000005248.1
H3A8E2
FASTKD2
8
LLPS-Lac-0504
ENSLACG00000011360.1
H3ATD1
FASTKD5
9
LLPS-Lac-3800
ENSLACG00000009507.1
H3AMC6
GRSF1
10
LLPS-Lac-3443
ENSLACG00000015434.2
H3B6K3
HSD17B10
11
LLPS-Lac-3956
ENSLACG00000017748.1
H3BE72
KIAA0391
12
LLPS-Lac-3464
ENSLACG00000011478.1
H3ATQ5
MCU
13
LLPS-Lac-1872
ENSLACG00000017664.1
H3BDX7
MRM1
14
LLPS-Lac-3720
ENSLACG00000016579.1
H3BAB5
MRM2
15
LLPS-Lac-3867
ENSLACG00000007157.1
H3AEL4
MRM3
16
LLPS-Lac-0851
ENSLACG00000010329.1
H3AQ10
MRPL19
17
LLPS-Lac-1543
ENSLACG00000008067.1
H3AHL8
MRPL43
18
LLPS-Lac-0636
ENSLACG00000014781.1
H3B4G1
MRPL47
19
LLPS-Lac-3708
ENSLACG00000014327.1
H3B2Z0
MRPS27
20
LLPS-Lac-1610
ENSLACG00000009463.1
H3AM76
MRPS31
21
LLPS-Lac-1618
ENSLACG00000003039.2
H3A182
MRPS7
22
LLPS-Lac-2904
ENSLACG00000013746.1
H3B142
MRPS9
23
LLPS-Lac-3353
ENSLACG00000003492.1
H3A2Q2
MTERF3
24
LLPS-Lac-0721
ENSLACG00000010030.1
H3AP30
MTPAP
25
LLPS-Lac-3558
ENSLACG00000017819.2
H3BEF2
NLRX1
26
LLPS-Lac-3901
ENSLACG00000001755.1
H2ZX43
NOA1
27
LLPS-Lac-3151
ENSLACG00000011059.1
H3ASD1
PNPT1
28
LLPS-Lac-2162
ENSLACG00000011518.1
H3ATV4
POLRMT
29
LLPS-Lac-2307
ENSLACG00000011172.1
H3ASQ9
PTCD1
30
LLPS-Lac-3206
ENSLACG00000014209.2
H3B2L1
PTCD2
31
LLPS-Lac-2314
ENSLACG00000013378.1
H3AZX5
SUCLG2
32
LLPS-Lac-2761
ENSLACG00000012594.2
H3AXD8
TFB1M
33
LLPS-Lac-2155
ENSLACG00000002036.2
H2ZY08
TRMT10C
34
LLPS-Lac-3229
ENSLACG00000001515.1
H2ZWC1
TRUB2
35
LLPS-Lac-2801
ENSLACG00000008161.1
H3AHX8
TWNK
36
LLPS-Lac-0608
ENSLACG00000010724.2
H3ARB4
YME1L1