Komagataella pastoris      Mitochondrial RNA granule


※ Mitochondrial RNA granule introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Mitochondrial RNA granules is a kind of these bodies of spherical shape that located in mitochondria with mitochondrial mRNAs and mitochondrial ribosomes components and it’s proved to be related to the posttranscriptional RNA processing and biogenesis of mitochondrial ribosomes (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Kop-0969
PAS_chr1-4_0022
C4QX83
PAS_chr1-4_0022
2
LLPS-Kop-0206
PAS_chr1-4_0191
C4QXQ1
PAS_chr1-4_0191
3
LLPS-Kop-1102
PAS_chr2-1_0442
C4R0P5
PAS_chr2-1_0442
4
LLPS-Kop-0604
PAS_chr3_0789
C4R5K7
PAS_chr3_0789
5
LLPS-Kop-0208
PAS_chr4_0101
C4R6V2
PAS_chr4_0101
6
LLPS-Kop-1247
PAS_chr4_0889
C4R984
PAS_chr4_0889