Cryptococcus neoformans      Mitochondrial RNA granule


※ Mitochondrial RNA granule introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Mitochondrial RNA granules is a kind of these bodies of spherical shape that located in mitochondria with mitochondrial mRNAs and mitochondrial ribosomes components and it’s proved to be related to the posttranscriptional RNA processing and biogenesis of mitochondrial ribosomes (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Crn-1461
CNC01970
Q5KKS9
CNC01970
2
LLPS-Crn-0537
CND05820
Q5KHN9
CND05820
3
LLPS-Crn-1484
CND06190
Q5KHK1
CND06190
4
LLPS-Crn-0536
CNG02250
Q5KDZ7
CNG02250
5
LLPS-Crn-0822
CNH00460
Q5KCB6
CNH00460
6
LLPS-Crn-0779
CNH02760
Q5KCZ5
CNH02760
7
LLPS-Crn-0047
CNI02560
Q5KBH0
CNI02560
8
LLPS-Crn-0697
CNK02350
Q5K9D3
CNK02350