Schizosaccharomyces pombe      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Scp-0266
SPBC1709.08
O74733
cft1
2
LLPS-Scp-1121
SPBC1709.15c
O74740
cft2
3
LLPS-Scp-0280
SPBC11B10.10c
P48003
pht1
4
LLPS-Scp-0856
SPAC1071.01c
Q10222
pta1
5
LLPS-Scp-1091
SPAC22G7.10
Q09801
SPAC22G7.10
6
LLPS-Scp-0470
SPAC27D7.14c
O42668
tpr1
7
LLPS-Scp-1101
SPAC17G6.16c
O13794
ysh1