Saccharomyces cerevisiae      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Sac-1243
YDR301W
Q06632
CFT1
2
LLPS-Sac-1437
YLR115W
Q12102
CFT2
3
LLPS-Sac-1450
YOL145C
P89105
CTR9
4
LLPS-Sac-1304
YJR093C
P45976
FIP1
5
LLPS-Sac-1481
YOL012C
Q12692
HTZ1
6
LLPS-Sac-0923
YLR277C
Q06224
YSH1
7
LLPS-Sac-0880
YPR107C
Q06102
YTH1