Pan paniscus      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 18 genes.  Reviewed (0 or Unreviewed (18

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Pap-2296
ENSPPAG00000019327.1
A0A2R8ZIR8
2
LLPS-Pap-4478
ENSPPAG00000029233.1
A0A2R9A4A3
BAHCC1
3
LLPS-Pap-0436
ENSPPAG00000043281.1
A0A2R9CHB1
CASP8AP2
4
LLPS-Pap-1847
ENSPPAG00000019280.1
A0A2R8ZJ40
CPSF1
5
LLPS-Pap-2264
ENSPPAG00000039666.1
A0A2R9BVW1
CPSF2
6
LLPS-Pap-4048
ENSPPAG00000042457.1
A0A2R9CMZ9
CPSF3
7
LLPS-Pap-0974
ENSPPAG00000043355.1
A0A2R9CR90
CPSF4
8
LLPS-Pap-2152
ENSPPAG00000043493.1
A0A2R9CRW2
CTCF
9
LLPS-Pap-0555
ENSPPAG00000040037.1
A0A2R9C767
CTR9
10
LLPS-Pap-0553
ENSPPAG00000031680.1
A0A2R9AJH5
DDX20
11
LLPS-Pap-1285
ENSPPAG00000029594.1
A0A2R9ABL3
FIP1L1
12
LLPS-Pap-0432
ENSPPAG00000030169.1
A0A2R9AGH0
GON4L
13
LLPS-Pap-0871
ENSPPAG00000037168.1
A0A2R9BGB7
H2AFV
14
LLPS-Pap-2417
ENSPPAG00000042389.1
A0A2R9CBT2
HINFP
15
LLPS-Pap-0546
ENSPPAG00000023465.1
A0A2R8ZP14
LSM10
16
LLPS-Pap-0229
ENSPPAG00000043838.1
A0A2R9CKQ4
NPAT
17
LLPS-Pap-0008
ENSPPAG00000043204.1
A0A2R9CQX0
SYMPK
18
LLPS-Pap-1901
ENSPPAG00000028702.1
A0A2R9A5P4
TP53