Nomascus leucogenys      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 17 genes.  Reviewed (0 or Unreviewed (17

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Nol-2108
ENSNLEG00000013242.3
G1RS99
CASP8AP2
2
LLPS-Nol-1932
ENSNLEG00000010633.3
G1RI66
CPSF1
3
LLPS-Nol-1972
ENSNLEG00000017132.2
G1S5M9
CPSF2
4
LLPS-Nol-1278
ENSNLEG00000013359.3
G1RSN3
CPSF3
5
LLPS-Nol-2906
ENSNLEG00000011074.3
A0A2I3GEK1
CPSF4
6
LLPS-Nol-3414
ENSNLEG00000004747.3
G1QXU6
CTCF
7
LLPS-Nol-2075
ENSNLEG00000017616.3
G1S7A1
CTR9
8
LLPS-Nol-1786
ENSNLEG00000004040.3
A0A2I3H3H8
DDX20
9
LLPS-Nol-1445
ENSNLEG00000008187.3
G1R9Y8
FIP1L1
10
LLPS-Nol-1424
ENSNLEG00000035449.1
A0A2I3H4H7
GON4L
11
LLPS-Nol-0022
ENSNLEG00000004039.3
G1QVD1
H2AFV
12
LLPS-Nol-0780
ENSNLEG00000007387.2
G1R739
HINFP
13
LLPS-Nol-1453
ENSNLEG00000033754.1
A0A2I3HX03
LSM10
14
LLPS-Nol-4139
ENSNLEG00000004178.2
G1QVT2
LSM11
15
LLPS-Nol-0431
ENSNLEG00000007228.2
A0A2I3G5V1
NPAT
16
LLPS-Nol-4201
ENSNLEG00000002369.3
G1QPK8
SYMPK
17
LLPS-Nol-3919
ENSNLEG00000009730.3
G1RF61
TP53