Neurospora crassa      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Nec-0970
NCU05347
Q873G4
hH2Az
2
LLPS-Nec-0718
NCU00095
Q7RYN3
NCU00095
3
LLPS-Nec-0528
NCU06869
V5IKS7
NCU06869
4
LLPS-Nec-0315
NCU02082
Q7SEY2
paa-3
5
LLPS-Nec-1204
NCU03479
Q8WZS6
ysh-1
6
LLPS-Nec-0751
NCU08353
Q7SGR2
yth-1