Mus musculus      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 18 genes.  Reviewed (5 or Unreviewed (13

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mum-1785
ENSMUSG00000032119.5
Q8K1K9
Hinfp
2
LLPS-Mum-4967
ENSMUSG00000044847.13
Q8BUV6
Lsm11
3
LLPS-Mum-1615
ENSMUSG00000033054.7
Q8BMA5
Npat
4
LLPS-Mum-0292
ENSMUSG00000023118.15
Q80X82
Sympk
5
LLPS-Mum-2526
ENSMUSG00000059552.13
P02340
Tp53
6
LLPS-Mum-4919
ENSMUSG00000039741.15
Q3UHR0
Bahcc1
7
LLPS-Mum-2474
ENSMUSG00000028282.12
Q9WUF3
Casp8ap2
8
LLPS-Mum-0044
ENSMUSG00000034022.8
Q9EPU4
Cpsf1
9
LLPS-Mum-0547
ENSMUSG00000041781.9
O35218
Cpsf2
10
LLPS-Mum-1892
ENSMUSG00000054309.9
Q9QXK7
Cpsf3
11
LLPS-Mum-0172
ENSMUSG00000029625.16
Q8BQZ5
Cpsf4
12
LLPS-Mum-2510
ENSMUSG00000005698.15
Q61164
Ctcf
13
LLPS-Mum-0765
ENSMUSG00000005609.16
Q62018
Ctr9
14
LLPS-Mum-0927
ENSMUSG00000027905.15
Q9JJY4
Ddx20
15
LLPS-Mum-2597
ENSMUSG00000029227.15
Q9D824
Fip1l1
16
LLPS-Mum-2623
ENSMUSG00000054199.17
Q9DB00
Gon4l
17
LLPS-Mum-0096
ENSMUSG00000041126.16
Q3THW5
H2afv
18
LLPS-Mum-2173
ENSMUSG00000050188.8
Q8QZX5
Lsm10