Drosophila melanogaster      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 17 genes.  Reviewed (10 or Unreviewed (7

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Drm-0072
FBgn0035205
Q7K0X3
Ctr9
2
LLPS-Drm-2425
FBgn0033806
Q7K0L8
FLASH
3
LLPS-Drm-0024
FBgn0011802
Q9V3C4
Gem3
4
LLPS-Drm-0075
FBgn0001197
P08985
His2Av
5
LLPS-Drm-0158
FBgn0033554
A1Z8C4
Lsm10
6
LLPS-Drm-0251
FBgn0033450
A1Z802
Lsm11
7
LLPS-Drm-0192
FBgn0085444
A8DYH1
mute
8
LLPS-Drm-2443
FBgn0260789
Q9W363
mxc
9
LLPS-Drm-2408
FBgn0013263
Q08605
Trl
10
LLPS-Drm-0203
FBgn0051151
Q3LHL9
wge
11
LLPS-Drm-0297
FBgn0015621
Q9VPT8
Clp
12
LLPS-Drm-1602
FBgn0027873
Q9V3D6
Cpsf100
13
LLPS-Drm-1843
FBgn0024698
Q9V726
Cpsf160
14
LLPS-Drm-1692
FBgn0261065
Q9VE51
Cpsf73
15
LLPS-Drm-0306
FBgn0025635
O77260
DmelCG17829
16
LLPS-Drm-1054
FBgn0037255
Q9VN31
Fip1
17
LLPS-Drm-0370
FBgn0037371
Q8MSU4
Sym