Cryptococcus neoformans      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Crn-0182
CNF00780
P0CM62
CFT1
2
LLPS-Crn-1167
CNB00490
Q5KMU2
CNB00490
3
LLPS-Crn-0596
CND02250
Q5KIP3
CND02250
4
LLPS-Crn-1408
CNF01910
Q5KFF7
CNF01910
5
LLPS-Crn-1065
CNL04080
P0CO00
HTZ1
6
LLPS-Crn-0368
CNH02710
P0CM88
YSH1
7
LLPS-Crn-0987
CNB01070
P0CS64
YTH1