Xenopus tropicalis      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Xet-2149
ENSXETG00000013568.3
F6ZDW4
ddx20
2
LLPS-Xet-1212
ENSXETG00000001951.3
Q28EL3
fus
3
LLPS-Xet-2283
ENSXETG00000000298.3
F6TG06
gemin2
4
LLPS-Xet-0052
ENSXETG00000022460.1
F6ZFB1
gemin4
5
LLPS-Xet-2780
ENSXETG00000019404.3
F7CD46
gemin5
6
LLPS-Xet-0473
ENSXETG00000009023.3
A9ULI9
gemin6
7
LLPS-Xet-1973
ENSXETG00000009880.2
F6RQK0
gemin7
8
LLPS-Xet-0409
ENSXETG00000013349.3
F7A353
gemin8
9
LLPS-Xet-3829
ENSXETG00000018189.3
F7AWW9
smn2
10
LLPS-Xet-1728
ENSXETG00000022919.3
Q66II8
snrnp70
11
LLPS-Xet-0013
ENSXETG00000022527.3
F6UJK0
strap
12
LLPS-Xet-0137
ENSXETG00000006317.3
Q28F51
tardbp