※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525

  Reviewed (0)  or Unreviewed (11) 

No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Tar-2663	ENSTRUG00000023712.1	A0A3B5K2Q9	ddx20
2		LLPS-Tar-1869	ENSTRUG00000021760.1	A0A3B5KGW5	gemin2
3		LLPS-Tar-1330	ENSTRUG00000010725.2	H2TQV5	gemin4
4		LLPS-Tar-1905	ENSTRUG00000000329.2	H2RKT8	gemin5
5		LLPS-Tar-1217	ENSTRUG00000021447.1	A0A3B5JYJ6	gemin6
6		LLPS-Tar-0441	ENSTRUG00000011620.2	H2TXF6	gemin7
7		LLPS-Tar-2514	ENSTRUG00000022129.1	A0A3B5KG45	gemin8
8		LLPS-Tar-2310	ENSTRUG00000000736.2	H2RNQ5	smn
9		LLPS-Tar-2453	ENSTRUG00000009202.2	H2TEQ8	snrnp70
10		LLPS-Tar-3018	ENSTRUG00000011050.2	H2TT91	strap
11		LLPS-Tar-0125	ENSTRUG00000012070.2	A0A3B5K5V3	tardbp