※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525

  Reviewed (0)  or Unreviewed (8) 

No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Tag-0168	ENSTGUG00000001548.1	H0YTI6
2		LLPS-Tag-1899	ENSTGUG00000013660.1	H0ZTZ6	DDX20
3		LLPS-Tag-2351	ENSTGUG00000012039.1	H0ZP71	GEMIN2
4		LLPS-Tag-1150	ENSTGUG00000000688.1	H0YR01	GEMIN5
5		LLPS-Tag-0814	ENSTGUG00000002093.1	H0YV38	GEMIN6
6		LLPS-Tag-2433	ENSTGUG00000008162.1	H0ZCV0	GEMIN8
7		LLPS-Tag-2643	ENSTGUG00000012395.1	H0ZQ72	STRAP
8		LLPS-Tag-0852	ENSTGUG00000003255.1	H0YYI1	TARDBP