※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525

  Reviewed (0)  or Unreviewed (12) 

No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Sus-0932	ENSSSCG00000006783.3	F1SBP3	DDX20
2		LLPS-Sus-0675	ENSSSCG00000030798.2	A0A287BPC6	FUS
3		LLPS-Sus-0682	ENSSSCG00000004985.3	I3L8G9	GEMIN2
4		LLPS-Sus-4638	ENSSSCG00000017809.3	A0A287BKG3	GEMIN4
5		LLPS-Sus-1717	ENSSSCG00000017066.3	A0A286ZWZ7	GEMIN5
6		LLPS-Sus-2631	ENSSSCG00000008482.3	F1S4S6	GEMIN6
7		LLPS-Sus-1448	ENSSSCG00000033194.1	A0A286ZSN9	GEMIN7
8		LLPS-Sus-2825	ENSSSCG00000012127.3	F1SQV2	GEMIN8
9		LLPS-Sus-1869	ENSSSCG00000016970.3	F1SK26	SMN1
10		LLPS-Sus-0583	ENSSSCG00000023792.2	A0A287AJ85	SNRNP70
11		LLPS-Sus-3311	ENSSSCG00000021410.2	I3LEQ7	STRAP
12		LLPS-Sus-0261	ENSSSCG00000023126.2	I3LNA4	TARDBP