Rattus norvegicus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ran-1943
ENSRNOG00000015274.7
F1MAM8
Ddx20
2
LLPS-Ran-0549
ENSRNOG00000023360.4
Q5PQK2
Fus
3
LLPS-Ran-1070
ENSRNOG00000004360.7
Q9QZP1
Gemin2
4
LLPS-Ran-1598
ENSRNOG00000055236.1
F1LWL5
Gemin4
5
LLPS-Ran-0187
ENSRNOG00000002645.7
D3ZGD0
Gemin5
6
LLPS-Ran-1213
ENSRNOG00000027332.2
G3V972
Gemin6
7
LLPS-Ran-1663
ENSRNOG00000049772.1
M0R5G2
Gemin7
8
LLPS-Ran-3909
ENSRNOG00000029038.4
Q6AY77
Gemin8
9
LLPS-Ran-2546
ENSRNOG00000018067.6
O35876
Smn1
10
LLPS-Ran-0074
ENSRNOG00000020763.8
B2RZ74
Snrnp70
11
LLPS-Ran-1952
ENSRNOG00000007134.6
Q5XIG8
Strap