Pongo abelii      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Poa-1891
ENSPPYG00000015533.2
A0A0A0MXR7
2
LLPS-Poa-1802
ENSPPYG00000001026.1
H2N6D3
DDX20
3
LLPS-Poa-0452
ENSPPYG00000005764.1
H2NL34
GEMIN2
4
LLPS-Poa-4462
ENSPPYG00000007759.1
H2NS36
GEMIN4
5
LLPS-Poa-0877
ENSPPYG00000015978.2
H2PH61
GEMIN5
6
LLPS-Poa-1617
ENSPPYG00000012479.2
H2P6G2
GEMIN6
7
LLPS-Poa-3955
ENSPPYG00000010106.1
A0A2J8U695
GEMIN7
8
LLPS-Poa-2738
ENSPPYG00000020136.2
A0A2J8W4H5
GEMIN8
9
LLPS-Poa-0067
ENSPPYG00000010234.2
H2NZL5
SNRNP70
10
LLPS-Poa-0329
ENSPPYG00000004334.2
H2NGQ7
STRAP
11
LLPS-Poa-0643
ENSPPYG00000001894.2
H2N950
TARDBP