Papio anubis      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Paa-0187
ENSPANG00000011343.2
A0A096NUP2
2
LLPS-Paa-0669
ENSPANG00000013601.2
A0A096MVQ6
3
LLPS-Paa-0952
ENSPANG00000017985.3
A0A096N683
DDX20
4
LLPS-Paa-1176
ENSPANG00000021275.2
A0A096NHY1
FUS
5
LLPS-Paa-2826
ENSPANG00000024610.2
A0A096P286
GEMIN4
6
LLPS-Paa-2257
ENSPANG00000024861.2
A0A096N3V8
GEMIN5
7
LLPS-Paa-0572
ENSPANG00000011066.2
A0A096NZ83
GEMIN6
8
LLPS-Paa-3192
ENSPANG00000012354.2
A0A0A0MX12
GEMIN7
9
LLPS-Paa-2388
ENSPANG00000016642.3
A0A096N4L3
GEMIN8
10
LLPS-Paa-3795
ENSPANG00000004068.3
A0A0A0MXK3
SNRNP70
11
LLPS-Paa-3089
ENSPANG00000008733.2
A0A2I3N5Q1
STRAP
12
LLPS-Paa-3304
ENSPANG00000017459.3
A0A096NBQ0
TARDBP