Pan troglodytes      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Pat-2847
ENSPTRG00000001105.5
H2PZN7
DDX20
2
LLPS-Pat-1614
ENSPTRG00000008038.6
H2RA80
FUS
3
LLPS-Pat-0079
ENSPTRG00000006291.6
H2Q877
GEMIN2
4
LLPS-Pat-0052
ENSPTRG00000008509.6
H2QBT1
GEMIN4
5
LLPS-Pat-0244
ENSPTRG00000017452.5
H2QRV6
GEMIN5
6
LLPS-Pat-0370
ENSPTRG00000011852.2
H2QHS4
GEMIN6
7
LLPS-Pat-3835
ENSPTRG00000044428.1
H2QGK7
GEMIN7
8
LLPS-Pat-4626
ENSPTRG00000048272.1
H2QYB2
GEMIN8
9
LLPS-Pat-0454
ENSPTRG00000011277.6
H2R5X1
SNRNP70
10
LLPS-Pat-2187
ENSPTRG00000004734.6
A0A2I3SHT8
STRAP
11
LLPS-Pat-0201
ENSPTRG00000000136.6
H2PY00
TARDBP