Ovis aries      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ova-1188
ENSOARG00000002203.1
W5NVY0
2
LLPS-Ova-2471
ENSOARG00000019651.1
W5QEF8
DDX20
3
LLPS-Ova-1067
ENSOARG00000008466.1
W5PF64
GEMIN2
4
LLPS-Ova-1397
ENSOARG00000011477.1
W5PPC8
GEMIN4
5
LLPS-Ova-3838
ENSOARG00000010195.1
W5PKH7
GEMIN5
6
LLPS-Ova-2918
ENSOARG00000008751.1
W5PG30
GEMIN6
7
LLPS-Ova-2059
ENSOARG00000011421.1
W5PP62
GEMIN7
8
LLPS-Ova-1537
ENSOARG00000011696.1
W5PQ06
GEMIN8
9
LLPS-Ova-0134
ENSOARG00000005425.1
W5P5W7
SMN2
10
LLPS-Ova-1891
ENSOARG00000020610.1
W5QHE9
STRAP
11
LLPS-Ova-2272
ENSOARG00000004268.1
W5P2C0
TARDBP