Oryctolagus cuniculus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Orc-2571
ENSOCUG00000017097.2
G1TD01
2
LLPS-Orc-0892
ENSOCUG00000025939.2
U3KNB2
DDX20
3
LLPS-Orc-1770
ENSOCUG00000021526.2
G1TV19
FUS
4
LLPS-Orc-1959
ENSOCUG00000000673.2
G1SDT7
GEMIN2
5
LLPS-Orc-1586
ENSOCUG00000002205.2
G1TXX1
GEMIN4
6
LLPS-Orc-2323
ENSOCUG00000011180.3
G1T0T3
GEMIN5
7
LLPS-Orc-3264
ENSOCUG00000015599.3
G1T9S1
GEMIN6
8
LLPS-Orc-3295
ENSOCUG00000022328.1
G1U7G0
LOC100339496
9
LLPS-Orc-1648
ENSOCUG00000015081.3
G1T8P3
SNRNP70
10
LLPS-Orc-0738
ENSOCUG00000013884.3
G1T6B3
STRAP